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Background: Bladder cancer (BC) and Renal cell carcinoma (RCC) are the most common urogenital cancers among both sexes, with a yearly global incidence of around 500 000 each. Both BC and RCC have been linked to diabetes. Poor glycemic control (malglycemia) is a serious consequence of diabetes and a possible consequence of systemic treatments used in BC and RCC. The objective of this study was to i
The distribution of putative cholinergic neurons in the brain of a cyprinid teleost was investigated by immunocytochemistry, with well‐characterized polyclonal antibodies to porcine choline acetyltransferase (ChAT), correlated with acetylcholinesterase (AChE) histochemistry. AChE‐positive neurons were more numerous than GhAT‐immunoreactive (ChAT‐IR) neurons. Regions with ChAT‐IR neurons generally
The field of microbial ecology has been developing rapidly, largely owing to the introduction of new molecular methods for identifying individuals, species and populations of microorganisms in nature. In contrast to traditional methods, the new ones do not require the isolation and culture of organisms from the environment. With many of the new methods, genotypes and species of microorganisms can
Ultrarelativistic heavy-ion collisions produce a state of hot and dense strongly interacting QCD matter called quark-gluon plasma (QGP). On an event-by-event basis, the volume of the QGP in ultracentral collisions is mostly constant, while its total entropy can vary significantly due to quantum fluctuations, leading to variations in the temperature of the system. Exploiting this unique feature of
Background: The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action. Methods: Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naïve early RA with moderate-severe disease activity were random
We investigate the seismicity rate behaviour in and around Greece during 2009, seeking significant changes in rate preceding larger events. For individual larger events it is difficult to clearly distinguish precursory rate changes from other, possibly unrelated, variations in seismicity. However, when we aggregate seismicity data occurring within a radius of 10 km and in a 50-day window prior to
ENVRI-FAIR is the connection of the ESFRI Cluster of Environmental Research Infrastructures (ENVRI) to the European Open Science Cloud (EOSC). The high-impact ambition of ENVRI-FAIR is to establish the technical preconditions for the successful implementation of a virtual, federated machine-to-machine interface to access environmental data and services provided by the contributing ENVRIs. This int
INTRODUCTION: Exercise interventions have a strong evidence base for falls prevention. However, exercise can be challenging to implement and often has limited reach and poor adherence. Digital technology provides opportunities for both increased access to the intervention and support over time. Further knowledge needs to be gained regarding the effectiveness of completely self-managed digital exer
Background: Intracoronary pressure wire measurement of fractional flow reserve (FFR) provides decision-making guidance during percutaneous coronary intervention (PCI). However, limited data exist on the effect of FFR on long-term clinical outcomes in patients with stable angina pectoris. Objectives: The purpose of this study was to determine the association between the usage of FFR and all-cause m
There are two levels to this thesis, the examination of the particular case and the exposition of the general approach. The case the thesis deals with is Louisiana’s coastal land-loss crisis and what can and should be done about it. I examine the current approach to coastal protection and restoration in the state of Louisiana, drawing on different economic theories of sustainable development and c
Background Heart failure (HF) commonly arises as a complication to cardiovascular diseases and is closely associated with various comorbidities. The impacts of these comorbidities in patients with HF are diverse. We aimed to analyze the increased risk for cardiovascular-related readmission within 100 days after discharge in patients with HF depending on their different comorbidities. Methods A pop
This thesis explores the extent to which international human rights law and international labour law place obligations on States to protect migrant workers’ fundamental rights, especially their rights to social security. More importantly, this thesis examines intra-ASEAN migrant workers’ accesses to the social security benefits, as defined by the ILO Social Security (Minimum Standards) Convention,
A metaphyseal bone defect due to infection, tumor or fracture leads to loss of cancellous and cortical bone. An animal model separating the cancellous and cortical healing was used with a combination of a macroporous gelatin-calcium sulphate-hydroxyapatite (Gel-CaS-HA) biomaterial as a cancellous defect filler, and a thin collagen membrane (CM) guiding cortical bone regeneration. The membrane was
Background: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confound
Background: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. Materials and methods: This is a cross-sectional analysis of baseline data from a randomized controlle
OBJECTIVE: Patients with extensive and long-standing ulcerative colitis have an increased risk of developing colorectal cancer and sub-epithelial fibrosis. The polypeptide transforming growth factor alpha (TGF-alpha) has mitogenic effects and it is believed that local overproduction may result in tumour formation and fibrosis. DESIGN: In the present study, we correlated the presence of TGF-alpha i
Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increa
Authentication theory deals with problems connected with the protection of information sent over insecure channels. This thesis concerns different problems in authentication theory. In particular, we consider unconditionally secure authentication, i.e., providing authentication protection agains an enemy equipped with unlimited computing power. Several topics in authentication theory are treated:
