Filetype
An article to be presented at the seminar “Breakdown and other Technological Phenomena”– directed by Professor Don Ihde to be held during the fall term of 2010 at the Techno-science Research Group; Department of Philosophy, Stony Brook University Aristotle understood the word “accident” as an attribute of a class or a thing that is not essential. The word comes from Latin accidentum meaning “some
Human soluble (S) and membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1.1.6) enzymes have been expressed at sufficiently high levels in Escherichia coil and in baculovirus-infected insect cells to allow kinetic characterization of the enzyme forms. The use of tight-binding inhibitors such as entacapone enabled the estimation of actual enzyme concentrations and, thereby, comparison of
'Sustainability' is an emerging issue that product development engineers must engage with to remain relevant, competitive and, most importantly, responsible. Yet, on examining the term 'sustainable', a plethora of definitions emerges, many of which are contradictory and confusing. This confusion and a general lack of understanding means that sustainability often gets relegated to an afterthought o
Possibilities to develop human monoclonal antibody specificities have recently been much facilitated by improvements of human hybridoma technology but even more so by the emerging phage-display technique. However, until recently very little has been known about the characteristics at the molecular level of the induced, T cell-dependent human antibody response, frequently targeted by these techniqu
Background: The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action. Methods: Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naïve early RA with moderate-severe disease activity were random
We investigate the seismicity rate behaviour in and around Greece during 2009, seeking significant changes in rate preceding larger events. For individual larger events it is difficult to clearly distinguish precursory rate changes from other, possibly unrelated, variations in seismicity. However, when we aggregate seismicity data occurring within a radius of 10 km and in a 50-day window prior to
ENVRI-FAIR is the connection of the ESFRI Cluster of Environmental Research Infrastructures (ENVRI) to the European Open Science Cloud (EOSC). The high-impact ambition of ENVRI-FAIR is to establish the technical preconditions for the successful implementation of a virtual, federated machine-to-machine interface to access environmental data and services provided by the contributing ENVRIs. This int
Objective: Late night spontaneous growth hormone (GH) pulses may influence the pituitary GH response to provocation tests. We evaluated GH response during arginine-insulin-tolerance test (AITT) after a GH peak during a short spontaneous nocturnal profile (SSNP) in children with short stature or low growth velocity. Design: Using SSNP and subsequent AITT, we examined 257 children 4–18 years old (13
Genetic testing has been applied for decades in clinical routine diagnostics of hematological malignancies to improve disease (sub)classification, prognostication, patient management, and survival. In recent classifications of hematological malignancies, disease subtypes are defined by key recurrent genetic alterations detected by conventional methods (i.e., cytogenetics, fluorescence in situ hybr
A method that could assess the whole vehicle non-exhaust particle (NEP) emission from the whole vehicle level was proposed by combining sealed housing with the chassis dynamometer. The intake and exhaust systems were connected to the out of the chamber to avoid possible effects on NEP emissions. The most distinguishing feature of the proposed method is the whole vehicle assessment of the NEP. Base
Hirschspung’s disease (HD) is a congenital gastrointestinal (GI) disorder frequently accompanied by GI complaints. Despite the lack of evidence regarding whether diet affects GI symptoms, advice on dietary changes is common. The aim was to investigate self-reported dietary effects on GI symptoms, comparing children with HD with healthy children. This was an observational, cross-sectional, self-rep
Introduction Simulation-based studies indicate that crisis checklist use improves management of patients with critical conditions in the emergency department (ED). An interview-based study suggests that use of an emergency manual (EM) - a collection of crisis checklists - improves management of clinical perioperative crises. There is a need for in-depth prospective studies of EM use during clinica
Introduction: High levels of toxic steroidal glycoalkaloids (SGAs) in potato tubers constitute a recognized food quality problem. Tuber SGA levels vary between potato cultivars and can increase after post-harvest stresses such as wounding and light exposure. A few cultivars, e.g., ‘Magnum Bonum’ and ‘Lenape,’ have been withdrawn from commercial sales due to excessive SGA levels during some cultiva
Background: Techniques for autofluorescence have been introduced to visualize the parathyroid glands during surgery and to reduce hypoparathyroidism after thyroidectomy. Methods: This parallel multicentre RCT investigated the use of Fluobeam® LX to visualize the parathyroid glands by autofluorescence during total thyroidectomy compared with no use. There was no restriction on the indication for su
AbstractBackgroundHypokalemia is common in hospitalized patients and associated with ECG abnormalities. The prevalence and prognostic value of ECG abnormalities in hypokalemic patients are, however, not well established.MethodsThe study was a multicentered cohort study, including all ault patients with an ECG and potassium level <4.4 mmol/L recorded at arrival to four emergency departments in Denm
Context: There is a dispute whether obesity without major metabolic derangements may represent a benign condition or not. Objective: We aimed to compare the plasma metabolome in obese subjects without metabolic syndrome (MetS) with normal-weight subjects without MetS and with obese subjects with MetS. Methods: This was a cross-sectional study at 2 academic centers in Sweden. Individuals from 3 pop
Purpose The overall objective in this study is to investigate the early development of radiographic knee osteoarthritis (OA) and its association with hand or/and knee OA, metabolic diseases, biomarkers, chronic pain, physical function and daily physical activity types. Participants The Halland osteoarthritis (HALLOA) cohort is a longitudinal cohort study that includes individuals with knee pain in
