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Triple-negative breast cancer (TNBC) is associated with poor prognosis and no targeted treatments are available for TNBC. Drugs inhibiting tyrosine kinases, such as vascular endothelial growth factor receptor 2 (VEGFR2) and KIT, have shown some promising results for patients with TNBC. The aim of the study was to investigate whether gains and/or amplifications of VEGFR2 and KIT, located at 4q12, o

Popular Abstract in Swedish Experimentella data från kollisioner mellan guldjoner vid hög energi har analyserat inom ramen för experimentet PHENIX, som finns vid en av kollisionspunkterna vid ''the Relativistic Heavy-Ion Collider'' på ''Brookhaven National Laboratory'', New York (USA). Kollisioner med tunga joner, så som guld, används i försök till att återskapa de förhållanden som fanns i univerThe properties of the basic building blocks of nuclear matter, the quarks, and their interactions are not known in detail, largely because observations are complicated by the confinement of quarks in composite particles. New insights can be gained from the study of nuclear matter in a deconfined phase, like the form of matter that the Universe consited of early in its evolution according to the Bi

Ice nucleation active bacteria have attracted particular attention due to their unique ability to produce specific ice nucleation proteins (INpros), which are the most efficient ice nuclei known as they induce nucleation at temperatures close to 0°C. Our model bacterium Pseudomonas syringae strain R10.79 produced INpros containing 67 tandem repeats, forming the proposed ice-binding surface. To und

Changes in mitochondrial DNA (mtDNA) content is a useful clinical biomarker for various diseases, however results are controversial as several analytical factors can affect measurement of mtDNA. MtDNA is often quantified by taking ratio between a target mitochondrial gene and a reference nuclear gene (mtDNA/nDNA) using quantitative real time PCR often on two separate experiments. It measures relat

It is not known how ghrelin affects insulin secretion in human islets from patients with type 2 diabetes (T2D) or whether islet ghrelin expression or circulating ghrelin levels are altered in T2D. Here we sought out to identify the effect of ghrelin on insulin secretion in human islets and the impact of T2D on circulating ghrelin levels and on islet ghrelin cells. The effect of ghrelin on insulin

Oligodendrocyte (OL) death may contribute to white matter pathology, a common cause of network dysfunction and persistent cognitive problems in patients with traumatic brain injury (TBI). Oligodendrocyte progenitor cells (OPCs) persist throughout the adult CNS and may replace dead OLs. OL death and OPCs were analyzed by immunohistochemistry of human brain tissue samples, surgically removed due to

Whereas governments are increasingly considering affirmative action programs to increase corporate board diversity, the effect of such programs can be superficial as they do not address the underlying problem, which is women's access to and inclusion in relevant corporate networks. To address this issue, we study the relationship among affirmative action programs (binding gender quotas and non-bin

In the wake of the discovery of superheavy elements, nuclear spectroscopy experiments aim at providing anchor points at the uppermost end of the nuclear chart for nuclear structure theory, which otherwise had to solely rely on extrapolations. In two runs in 2019 and 2020, such a nuclear spectroscopy experiment was conducted to study α-decay chains stemming from isotopes of flerovium (element Z = 1

The γ-ray emission from the nuclei 62,64Fe following Coulomb excitation at bombarding energy of 400-440 AMeV was measured with special focus on E1 transitions in the energy region 4-8 MeV. The unstable neutron-rich nuclei 62,64Fe were produced at the FAIR-GSI laboratories and selected with the FRS spectrometer. The γ decay was detected with AGATA. From the measured γ-ray spectra the summed E1 stre

Somatic mosaicism, the presence of genetically distinct cells within an organism, has been increasingly associated with human morbidity, ranging from being a cause of rare syndromes to a risk factor for common disorders such as malignancy and cardiovascular disease. Previous studies interrogating the normal prevalence of somatic mosaicism have focused on adults. We here present an estimate of the

Sperm storage in Adalia bipunctata (L.) (Coleoptera, Coccinellidae) was examined and compared between diapausing and non-diapausing females. We observed that non-diapausing females store on average 13,688 (+/-722, S.E.) sperm in their spermatheca and that every female examined had sperm in storage (n = 16). In contrast, most diapausing females had empty spermatheca and only two had sperm in storag