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New combustion concepts are being investigated to develop cleaner engines. One of the most promising is partially premixed combustion. The mechanisms of this combustion mode and its impact on performance and emissions have been studied in the previous years. Nevertheless, little research has been done from the point of view of heat transfer. In particular, the influence of the injection strategy o

Partially premixed combustion using gasoline-like fuels on compression ignition engines shows great potentials to break the soot-nitrogen oxides trade off and reduce both emissions simultaneously. By simply adjusting the dilution strategies and injection events, the control of partially premixed combustion is relatively easier compared to other low-temperature combustion concepts. However despite

The streaming instability provides an efficient way of overcoming the growth barriers in the initial stages of the planet formation process. Considering the realistic case of a particle size distribution, the dynamics of the system is altered compared to the outcome of single size models. In order to understand the outcome of the multispecies streaming instability in detail, we perform a large par

High hyperdiploid acute lymphoblastic leukemia (ALL) is one of the most common malignancies in children. The main driver event of this disease is a nonrandom aneuploidy consisting of gains of whole chromosomes but without overt evidence of chromosomal instability (CIN). Here, we investigated the frequency and severity of defective sister chromatid cohesion—a phenomenon related to CIN—in primary pe

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease. The only option for curative treatment is resection of the tumor followed by standard adjuvant chemotherapy. Yet, early relapse due to chemoresistance is almost inevitable. Herein, we delineated the genetic intratumor heterogeneity in resected PDAC, with the aim to identify evolutionary patterns that may be associated with ov

Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods In Sweden 362 patients (15-34 years) classified as Type 1 DM were,, included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA(1c) and insulin d

The 100 000 Genome Project aims to develop a diagnostics platform by introducing whole genome sequencing (WGS) into clinical practice. Samples from patients with chronic lymphocytic leukaemia were subjected to WGS. WGS detection of single nucleotide variants and insertion/deletions were validated by targeted next generation sequencing showing high concordance (96·3%), also for detection of sub-clo

Aerosol particles are a complex component of the atmospheric system which influence climate directly by interacting with solar radiation, and indirectly by contributing to cloud formation. The variety of their sources, as well as the multiple transformations they may undergo during their transport (including wet and dry deposition), result in significant spatial and temporal variability of their p

Non-exhaust sources, such as brakes, tyres, roads, and clutches, emit a large portion of airborne particles in road transportation, from ultrafine to coarse sizes. While airborne wear particle emissions from brakes and road-tyre contacts have been studied extensively, emissions from clutches have been overlooked. A preliminary study using a novel test rig has indicated that dry clutches also emit

Interconnected modular microfluidic devices (MDs) configured in series and parallel have significantly advanced applications like multi-step chemical reactions with enhanced efficiency, production quality, throughput, and automation. However, managing these interconnected MDs is challenging due to complex fluidic networks and interdependent flow dynamics. This study presents a clamped pressure con