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RIFM fragrance ingredient safety assessment, 3-octanol, CAS Registry Number 589-98-0

Summary: The existing information supports the use of this material as described in this safety assessment. 3-Octanol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 3-hexanol (CAS # 623-37-0) show that 3-octanol is not expected to

RIFM fragrance ingredient safety assessment, 3,3,5-trimethylcyclohexyl acetate, CAS Registry Number 67859-96-5

RIFM fragrance ingredient safety assessment, 2-nonanone, CAS Registry Number 821-55-6

RIFM fragrance ingredient safety assessment, N-lactoyl ethanolamine, CAS Registry Number 5422-34-4

RIFM fragrance ingredient safety assessment, 2,5,7-octatrien-1-ol, 2,6-dimethyl-, 1-acetate, CAS Registry Number 197098-61-6

RIFM fragrance ingredient safety assessment, benzene, 1,3,5-trimethoxy-, CAS Registry Number 621-23-8

RIFM fragrance ingredient safety assessment, 4-tert-butyltoluene, CAS Registry Number 98-51-1

Stretch increases alveolar type 1 cell number in fetal lungs through ROCK-Yap/Taz pathway

Accurate fluid pressure in the fetal lung is critical for its development, especially at the beginning of the saccular stage when alveolar epithelial type 1 (AT1) and type 2 (AT2) cells differentiate from the epithelial progenitors. Despite our growing understanding of the role of physical forces in lung development, the molecular mechanisms that regulate the transduction of mechanical stretch to

RIFM fragrance ingredient safety assessment, 8-isopropyl-6-methylbicyclo[2.2.2]oct-5-ene-2-carbaldehyde, CAS Registry Number 67845-30-1

RIFM fragrance ingredient safety assessment, octahydro-8,8-dimethylnaphthalene-2-carbaldehyde, CAS Registry Number 68738-94-3

RIFM fragrance ingredient safety assessment, citronellyl acetate, CAS Registry Number 150-84-5

RIFM fragrance ingredient safety assessment, cis-3-hexenyl propionate, CAS Registry Number 33467-74-2

RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl salicylate, CAS Registry Number 68555-58-8

RIFM fragrance ingredient safety assessment, tridecene-2-nitrile, CAS Registry Number 22629-49-8

RIFM fragrance ingredient safety assessment, methyl phenethyl ether, CAS Registry Number 3558-60-9

RIFM fragrance ingredient safety assessment, cis-3-hexenyl butyrate, CAS Registry Number 16491-36-4

RIFM fragrance ingredient safety assessment, 4,8-undecadienal, (4Z,8E)-, CAS Registry Number 1958027-16-1

RIFM fragrance ingredient safety assessment, 4,7-methano-1H-inden-5-ol, 3a,4,5,6,7,7a-hexahydrodimethyl-, CAS Registry Number 79771-15-6

RIFM fragrance ingredient safety assessment, phenethyl phenylacetate, CAS Registry Number 102-20-5

The existing information supports the use of this material as described in this safety assessment. Phenethyl phenylacetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that phenethyl phenylacetate is not genotoxic. Data provide a calculated MOE >10

RIFM fragrance ingredient safety assessment, tetrahydro-6-(3-pentenyl)-2H-pyran-2-one, CAS Registry Number 32764-98-0

The existing information supports the use of this material as described in this safety assessment. Tetrahydro-6-(3-pentenyl)-2H-pyran-2-one was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that tetrahydro-6-(3-pentenyl)-2H-pyran-2-one is not genotoxic.