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We have estimated the hydration free energy for 20 neutral drug-like molecules, as well as for three series of 6-11 inhibitors to avidin, factor Xa, and galectin-3 with four different continuum solvent approaches (the polarised continuum method the Langevin dipole method, the finite-difference solution of the Poisson equation, and the generalised Born method), and several variants of each, giving
AIM AND OBJECTIVE: To describe the study design of a randomised controlled trial with the aim of comparing two different regimes for children with newly diagnosed type 1 diabetes; hospital-based care and hospital-based home care. BACKGROUND: Procedures for hospital admission and sojourn in connection with diagnose vary greatly worldwide and the existing evidence is insufficient to allow for any c
Ett för entreprenadavtalet utmärkande drag är beställarens ändringsbefogenhet, vilken innebär att beställaren under entreprenadtidens gång har möjlighet att ändra avtalets omfattning. Att utnyttjandet av ändringsbefogenheten vanligen medför produktionsförluster för entreprenören är den generella uppfattningen i branschen. Ersättning för denna typ av kostnader går att utfå med hjälp av AB 04 kap. 6A distinctive feature of the construction contract is the client’s authority to change the scope of the agreement. The fact that the use of the change authority usually entails production losses for the contractor is the general perception of the industry. Compensation for this type of costs can be obtained according to AB 04 chapter 6, clause 5, when a change order or a change in relation to the
This report is written during a Master Thesis carried out at Volvo Aero Corporation, VAC, in relation with the Division of Production and Materials Engineering at Lund Institute of Technology. The purpose with this report is to get a better insight in some of the problems occurring during the manufacturing of a space nozzle. At VAC a new kind of nozzle wall design has been introduced for their sp
In the laminator there are three laminator stations where protective layers are applied to the paperboard. In each station there are several rollers which help perform the lamination process, the most important rollers to be considered in this thesis are the nip roller and the chill roller. The nip roller is pushed towards the chill roller using hydraulic cylinders , thus creating a narrow contact
Although outcomes for newly diagnosed acute myeloid leukaemia (AML) have been incrementally improved over the last decades, management of relapsed and refractory (R/R) AML remains a medical challenge. A curative intent for R/R AML usually involves chemotherapy (with or without targeted therapy) with subsequent consolidation, including allogeneic haematopoietic stem cell transplantation. Despite th
We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female
BackgroundCarotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualit
There is growing evidence that the environment experienced by one generation can influence phenotypes in the next generation via transgenerational plasticity (TGP). One of the best-studied examples of TGP in animals is predator-induced transgenerational plasticity, whereby exposing parents to predation risk triggers changes in offspring phenotypes. Yet, there is a lack of general consensus synthes
BACKGROUND: Knowledge about the prevalence of women with breast implants is paramount in calculations of risks and in estimations of effects on screening and breast cancer treatment. Most of the estimations of prevalence made to date are rough and often based on sales data. The main aim of this study was to calculate the prevalence of breast implants in Swedish women. The secondary aim was to inv
PURPOSE: Histologic grade is currently the best predictor of clinical course in chondrosarcoma patients. Grading suffers, however, from extensive interobserver variability and new objective markers are needed. Hence, we have investigated DNA copy numbers in chondrosarcomas with the purpose of identifying markers useful for prognosis and subclassification. EXPERIMENTAL DESIGN: The overall pattern o
The important role of fire in regulating vegetation community composition and contributions to emissions of greenhouse gases and aerosols make it a critical component of dynamic global vegetation models and Earth system models. Over two decades of development, a wide variety of model structures and mechanisms have been designed and incorporated into global fire models, which have been linked to di
Neural electrodes used for measurements of action potentials in brain cells are often made of gold. These electrodes need to be suciently small to cover only one brain cell, but this induces the problem of increased impedance since impedance scales inversely with surface area. This means that if the surface area is too small, only noise will be measured. One way to overcome this problem is to try
It is necessary for all industries to work actively to minimize their impact on the climate, including the construction industry, which accounts for a significant part of Sweden's total CO_2-emissions. Development to produce concrete and steel with more environmentally friendly processes is ongoing, but to lower emissions immediately and achieve long-term sustainability, we need to develop met
Thomson REVIEW CURRENT OPINION Genetics and its potential to improve type 1 diabetes care Copyrig 1752-296X Copyright 2017 Wolte Stephen S. Rich Purpose of review The genetic basis of type 1 diabetes (T1D) is being characterized through DNA sequence variation and cell type specificity. This review discusses the current understanding of the genes and variants implicated in risk of T1D and how gene
Barbaricum 070302 Den andliga makten Entré Reception The Spiritual Beliefs Vapenoffer War Sacrifies Soldaten The Soldier Den Världsliga makten The Worldly Dominion Eldstaden The Fireplace Uppåkratemplet The Uppåkra Temple Bägaren och skålen The Beaker and the Bowl Guldgubbarna The Gold-Figure Foils Den nakna gudinnan The Naked Goddess Porten The Gate Information Information Keramiken The Ceramics
https://www.historiskamuseet.lu.se/sites/historiskamuseet.lu.se/files/2023-09/Barbaricumboken%20pdf%202007.pdf - 2026-07-16
