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The use of fetal bovine serum hinders obtaining reproducible experimental results and should also be removed in hormone and growth factor studies. In particular hormones found in FBS act globally on cancer cell physiology and influence transcriptome and metabolome. The aim of our study was to develop a renal carcinoma serum free culture model optimized for (embryonal) renal cells in order to selec

Background: Health-related quality of life (HRQoL) was a secondary end point in AGO-OVAR 16, which randomized 940 patients with EOC after first-line chemotherapy to maintenance pazopanib (PZ) or placebo (P). Additional post hoc analyses were carried out to investigate additional patient-centered end points. Patients and methods: HRQoL was measured with EORTC-QLQ-C30, QLQ-OV28 and EQ-5D-3L. Pre-spe

Soil organic matter (SOM) supports the Earth's ability to sustain terrestrial ecosystems, provide food and fiber, and retains the largest pool of actively cycling carbon. Over 75% of the soil organic carbon (SOC) in the top meter of soil is directly affected by human land use. Large land areas have lost SOC as a result of land use practices, yet there are compensatory opportunities to enhance prod

In the present work, we have evaluated the performance of different embedded atom method (EAM) andsecond-nearest neighbour modified embedded atom method (2NN-MEAM) potentials based on their predictivecapabilities for modelling fracture in single- and bicrystalline tungsten. As part of the study, a new 2NN-MEAMwas fitted with emphasis on reproducing surface, unstable stacking fault and twinning ene

Let H be a space of analytic functions on the unit ball Bd in Cd with multiplier algebra Mult(H). A function f ∈ H is called cyclic if the set [f], the closure of {ϕf : ϕ ∈ Mult(H)}, equals H. For multipliers we also consider a weakened form of the cyclicity concept. Namely for n ∈ N0 we consider the classes Cn(H) = {ϕ ∈ Mult(H): ϕ /= 0, [ϕn] = [ϕn+1]}. Many of our results hold for N:th order radi

ALG13-Congenital Disorder of Glycosylation (CDG), is a rare X-linked CDG caused by pathogenic variants in ALG13 (OMIM 300776) that affects the N-linked glycosylation pathway. Affected individuals present with a predominantly neurological manifestation during infancy. Epileptic spasms are a common presenting symptom of ALG13-CDG. Other common phenotypes include developmental delay, seizures, intell

Numerical studies were performed to estimate the heat transfer and hydrodynamic properties of a forced convection turbulent flow using three-dimensional horizontal concentric annuli. This paper applied the standard k–ε turbulence model for the flow range 1 × 104 ≤ Re ≥ 24 × 103. A wide range of parameters like different nanomaterials (Al2O3, CuO, SiO2 and ZnO), different particle nanoshapes (spher

Scintillators based on Ce-doped garnets are regularly co-doped with Mg2+ or Ca2+ to form Ce ions in 4+ state and reduce undesired afterglow. However overly high Ce4+ concentration leads to poor light yield performance. In order to understand the reason for variation in luminescence efficiency of Ce3+- and Ce4+-doped garnets we investigate the differences in energy conversion processes in complex L

Two main topics are dealt with in this thesis. Firstly, the performance of condensing boilers with finned tube heat exchangers and premix burners is evaluated. Secondly, ways of avoiding condensate formation in the flue system are evaluated. In the first investigation, a transient heat transfer approach is used to predict performance of different boiler configurations connected to different heati

This paper presents the results of the 2022 Groundwater Time Series Modelling Challenge, where 15 teams from different institutes applied various data-driven models to simulate hydraulic-head time series at four monitoring wells. Three of the wells were located in Europe and one was located in the USA in different hydrogeological settings in temperate, continental, or subarctic climates. Participa

Background A substantial untapped potential for risk reduction may be fulfilled by applying intensive lifestyle interventions targeting the co-existing risky lifestyle factors Smoking, Nutrition (both malnutrition and obesity), risky Alcohol intake, and Physical inactivity (SNAP) before surgery. This trial will compare the effect of combined and individually tailored prehabilitation with standard

The concept of importance of criteria is used as a central element in several decision making contexts, specifically in value aggregation, e.g. as an input to decision support tools. For example, in the analytic hierarchy process (AHP) decision makers are asked to estimate how much more important one criterion is than another. However, it is not clear how people understand aggregation models based

Adapting successes of policy transition from one city to another has been more difficult than single case of successful sustainability-driven projects and developments. A thorough understanding of local biophysical and socio-economic conditions is essential in formulating effective development plans and policies. Here, we propose the use of a social-ecological model as a comparative tool to help u

This paper presents the results of the 2022 Groundwater Time Series Modelling Challenge, where 15 teams from different institutes applied various data-driven models to simulate hydraulic-head time series at four monitoring wells. Three of the wells were located in Europe and one was located in the USA in different hydrogeological settings in temperate, continental, or subarctic climates. Participa

Popular Abstract in Swedish Mycket få människor omkring oss vet innebörden av ordet kavitation, förutom de som såg filmen "The Hunt for Red October" och kan relatera kavitation till Sean Connery i en ubåt. Kavitation motsvarar bildandet av bubblor, som kan likna kokande vatten i en kastrull. Men den uppstår inte på grund av en hög temperatur utan på grund av ett lågt tryck. Den finns i de flesta tVery few people around us know the meaning of the word cavitation, except from those who saw the movie "The Hunt for Red October" and can relate cavitation to Sean Connery in a submarine. Some of them know that it corresponds to the formation of bubbles, due to a pressure drop, and causes erosion and noise. However, cavitation is much more complex. A large amount of research work has been done ove

Private set intersection is a technique for finding the intersection of (two) parties' sets without disclosing anything else, and it finds it use in e.g. contact discovery, finding friends who are already on a social platform. Multi-party threshold private set intersection is an extension of this which allows multiple parties and only reveals the intersection if the intersection is larger than

In markets with fierce competition and low switching costs, the capability to keep customers is just as important as the capability to get new customers. One of the cornerstones of efficiently keeping customers from churning is the ability to identify customers that are more prone to leaving the company than others. This way, churn prevention resources and measures can be efficiently directed towa

Uppmärksammandet av att organisationer har ett arbetsgivarvarumärke, i kombination med en ökad efterfrågan på högkvalificerad arbetskraft, har lett till uppkomsten av ett flertal best practice-modeller och konsultbyråer som specialiserat sig på att förvalta organisationers rykten som arbetsgivare. Tidiga definitioner av det som kommit att kallas för employer branding beskriver målet med detta att

Colorless distributed combustion (CDC) is a promising novel technology to reduce emissions of carbon monoxide and nitrogen oxides in gas turbine combustors. CDC features a different flame regime than conventional gas turbine combustors, associated with a distributed reaction zone and low and uniform temperatures due to dilution of combustion air with exhaust gases. In this thesis, an attempt has b