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Brevmall Postal address Box 117, 221 00 LUND Visiting address Gamla Kirurgen, Sandgatan 3 Telephone +46 46 222 72 06, switchboard +46 46 222 00 00 Fax +46 46 222 44 11 Email Anders.Kirchner@sam.lu.se Website http://www.sam.lu.se Board of the Facul ty o f Soc ia l Sc iences Appointment rules and general instructions for the appointment of academic staff at the Faculty of Social Sciences These instr
Functional studies of microRNAs in neural stem cells: problems and perspectives REVIEW ARTICLE published: 07 February 2012 doi: 10.3389/fnins.2012.00014 Functional studies of microRNAs in neural stem cells: problems and perspectives Malin Åkerblom1,2, Rohit Sachdeva1,2 and Johan Jakobsson1,2* 1 Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscien
https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/fnins-06-00014.pdf - 2026-05-07
Fiji has been plagued with issues hindering its economic development. Having experienced 4 coup d’états in the last 40 years owing to tension between the countries’ two majority ethnic groups, Fiji has developed a reputation for political instability. Lacklustre growth, weak structural transformation, and limited economic diversification have led to increased poverty levels. With the Covid-19 pand
The aim of this thesis was to elucidate developments in epidemiology, clinical manifestations and complications in Chlamydia trachomatis (C.trachomatis) and Mycoplasma genitalium (M.genitalium) infection. In study I the frequencies of non-gonococcal salpingitis, gonococcal salpingitis and ectopic pregnancy (EP) were observed over a period of 28 years and correlated to the prevalence of Neisseria g
Background: Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as their prohibitive cost. However, the limited availability of antibodies is a key barrier to the development of a lower cost alternative, namely a discrete collection of immunohist
The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). (I and II) Autoantibodies to the C3 cleaving enzyme complex of the alternative pathway, C3 nephritic facto
Purpose: To assess the additional value of subtraction ictal single-photon emission computed tomography (SPECT) coregistered to MRI (SISCOM) for localization of the epileptogenic zone in patients with drug-resistant epilepsy scheduled for invasive video-EEG (VEEG) before epilepsy surgery by a descriptive study from clinical practice. Methods: Forty-nine consecutive epilepsy patients between Januar
Cities of the future face challenges with respect to the quantity and quality of water resources, and multiple managerial options need to be considered in order to safeguard urban surface water quality. In a recently completed project on 'Source control options for reducing emissions of Priority Pollutants' (ScorePP), seven emission control strategies (ECSs) were developed and tested within a semi
Naturliga faror kan inträffa överallt på jorden. När en naturrisk inträffar kan detta leda till en stor inverkan på människor, miljö och samhälle för lång tid framöver. Naturliga faror klassas då som naturkatastrofer. Värst drabbade är utvecklingsländer, där ekonomin, infrastrukturen och de sociala skyddsnäten är sämre än i industriländer. Naturkatastrofer har ökat markant det senaste århundradet Natural hazards can occur anywhere. Natural hazards become natural disasters when they have great impact on people and environment. Developing countries are more affected than industrial countries. Natural disasters have increased in number the last century, mainly due to the following reasons: climate change, population increase, urbanisation as well as degradation of the environment. Crisis mana
The regulation of the European parliament and the Council (EG) nr. 864/2007 on the law applicable to non-contractual obligations is known as Rome II. Rome II contains a conflict rule in art. 7 which determines the law applicable to a claim involving environmental damages connected with more than one state. This conflict rule does not only apply to cases of damage to property and persons, but also
We have investigated the effects of the novel imidazoline compound (+)-2-(2-(4,5-dihydro-1H-imidazol-2-yl)-thiopene-2-yl-ethyl)pyridine (NNC77-0074) on stimulus-secretion coupling in isolated pancreatic alpha- and beta-cells. NNC77-0074 stimulated glucose-dependent insulin secretion in intact mouse pancreatic islets. No effect was observed at less than or equal to 2.5 mM glucose and maximal stimul
Biobanks are a major resource to access and measure biological constituents that can be used to monitor the status of health and disease, both in unique individual samples and within populations. Most “omic” activities rely on access to these collections of stored samples to provide the basis for establishing the ranges and frequencies of expression. Furthermore, information about the relative abu
Nitrous oxide, carbon dioxide and methane are greenhouse gases (GHG) emitted from wastewater treatment that contribute to its carbon footprint. As a result of the increasing awareness of GHG emissions from wastewater treatment plants (WWTPs), new modelling, design, and operational tools have been developed to address and reduce GHG emissions at the plant-wide scale and beyond. This paper reviews t
Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female)
Background Olaparib, a novel, orally active poly(ADP-ribose) polymerase (PARP) inhibitor, induced synthetic lethality in BRCA-deficient cells. A maximum tolerated dose and initial signal of efficacy in BRCA-deficient ovarian cancers have been reported. We therefore assessed the efficacy, safety, and tolerability of olaparib alone in women with BRCA1 or BRCA2 mutations and advanced breast cancer. M
The rs738409 C > G single-nucleotide polymorphism in PNPLA3 leads to a missense mutation (I148M) which increases liver fat but does not cause insulin resistance. We hypothesised that patients with non-alcoholic fatty liver disease (NAFLD) due to the PNPLA3 variant ('PNPLA3 NAFLD'aEuro parts per thousand= PNPLA3-148MM) do not have adipose tissue (AT) inflammation in contrast with those with NAFLD d
In order to survive, individuals must be able to recognise and eliminate pathogens. The genes of the Major Histocompatibility Complex (MHC) play an essential role in this process in vertebrates as their diversity affects the repertoire of pathogens that can be recognised by the immune system. Emerging evidence suggests that birds within the parvorder Passerida possess an exceptionally high number
