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BACKGROUND: Small-cell lung cancer (SCLC) molecular subtypes have been primarily characterized based on the expression pattern of the following key transcription regulators: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P) and YAP1 (SCLC-Y). Here, we investigated the proteomic landscape of these molecular subsets with the aim to identify novel subtype-specific proteins of diagnostic and therapeut
Health-related quality of life (HRQL) is a multidimensional concept which captures the individual’s perception of treatment burden. Evaluating HRQL during treatment for childhood cancer provides insight into the burden of the treatment from the child’s and/or parent’s perspective.In this review, we aimed to describe Patient-Reported Outcome Measures (PROMs) used to measure HRQL during treatment, d
The worldwide adoption of renewable energy mandates, together with the widespread utilization of biofuels has created a sharp increase in the production of biodiesel (fatty acid alkyl esters). As a consequence, the production of glycerol, the main by-product of the transesterification of fatty acids, has increased accordingly, which has led to an oversupply of that compound on the markets. Therefo
Background: Proton radiotherapy (RT) is an attractive tool to deliver local therapy with minimal dose to uninvolved tissue, however, not suitable for all patients. The aim was to explore complications, especially severe late complications (grades 3–4), following proton RT delivered to a complete Swedish cohort of paediatric patients aged <18 years treated 2008–2019. Material and Methods: Data was
Research concerning endangered languages has evolved from research on such languages, to research for their speaker communities, and more recently to research with speakers of endangered languages (Grinevald & Bert 2011:62). Such collaborations between communities and linguists are by now considered best practice and an idealized goal (Leonard & Haynes 2010) to foster more equitable relati
Background and Objective: The recent multi-country outbreak of human monkeypox (HMPX) in non-endemic regions poses an emerging public health concern. University students in health schools/faculties represent a core knowledgeable group that can be helpful to study from a public health point of view. As future healthcare workers, assessment of their knowledge and attitude towards emerging zoonotic v
Soil organic matter (SOM) decomposition in response to global change represents a critical uncertainty in coupled carbon (C) cycle-climate models. Much of this uncertainty arises from our limited mechanistic knowledge of the effects of organic C input frequency on SOM decomposition. Based on a three-source-partitioning isotopic approach (14C glucose addition to soil continuously labeled by C4 plan
Background: The use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) has been associated with reduced relapse rates and accumulation of disability. However, studies examining impact of DMT on risk of transition to secondary progressive MS (SPMS) leveraging population-based nationwide data are still rare. Here, we determine the population incidence of conversion to SPMS using two co
Background: Urinary retention is common in elderly patients undergoing acute hip fracture surgery. Avoiding overfilling the urinary bladder is important to avoid detrusor muscle damage and associated motility problems. The aim of this study was to analyse associations between the co-creation of a nurse-driven urinary catheterisation protocol and the incidence of bladder distension in patients unde
We built machine learning and image analysis tools in order to forecast winter wheat yield based on a rich multi dimensional tensor of agricultural information spanning different scales. This information consists of satellite multi-band images, local soil samples obtained from national databases, local weather as well as field data from 23 farms cultivating winter wheat in southern Sweden. This is
Background: The influence of familial factors on the prognosis of ischemic stroke (IS) is unknown. This nationwide follow-up study evaluated familial mortality risks of IS among Swedish sibling pairs hospitalized for IS. Methods: We linked Swedish nationwide registers for the identification of 1380 Swedish born sibling pairs (2760 cases), where both siblings were hospitalized for first-time IS bet
Background: Early initiation of breastfeeding offers nutritional and immunological benefits to the newborn, which is critical for health and survival. Understanding factors associated with timely initiation of breastfeeding is crucial for healthcare providers and policy-makers. This study aimed to assess the prevalence and factors associated with early initiation of breastfeeding among mothers wit
Objectives: In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline predictors of Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) inactive disease (primary objective) and clinically important improvement (CII) at 6 months, and drug retention at 12-months across 15 European registries. Metho
The aim of this masters dissertation is to investigate how problems that includes fluids can be solved numerical through FE-analysis. The problem at hand is to predict the impact force implied by breaking ocean waves on vertical coastal structures. The importance that coastal areas has on human society both from a perspective of economy, infrastructure and recreation are indubitable. Furthermore,
Social workers in Swedish child welfare operate within a context where children’s right to express their views is legally regulated, while professional decision-making often takes place in complex situations involving different perspectives and interests. This study aimed to explore how social workers describe their use of professional discretion in cases where children’s and parents’ wishes do no
We propose and analyze a microwave spin-photon interface based on a circular double quantum dot, inspired by recent experimental observations of anisotropic g-factors and orbital ring states in InAs nanowires. We develop an effective theoretical model, capturing the interplay of spin-orbit coupling and the magnetic flux, and show how ring states form at crossings of odd and even geometric parity o
Populärvetenskaplig sammanfattning: Naturbetesmarkerna minskade med 86,7% från 1927 till 1990. Denna minskning är alarmerande eftersom många idag hotade och sällsynta arter är beroende av dessa. En stor del av anledningen till detta är att staten ända in på 1980-talet i sin rådgivning danade för att dessa marker antingen skulle bearbetas med konstgödsel och ogräsbekämpning eller planteras med träd
The rise in prevalence and severity of obesity and related diseases imposes increasing costs on society. The objective of this thesis is to discuss and estimate the possible effects of a so-called fat tax as a tool for minimizing these costs. Two alternatives for differentiation of the value-added tax (VAT) on food are compared. The first alternative is an increase of the VAT levied on food contai
Hur många gånger har du tagit på dig en svart tröja och sedan upptäckt hur varmt det blir när solen tittar fram? Med hjälp av den erfarenheten är det säkert tydligt att mörka material värms upp mer av solens strålar än ljusa material. Man säger att mörka material ”tar till sig”, eller absorberar, en större andel av den strålning som solen sänder ut i form av ljus. Det som inte absorberas kan istälHuman population on Earth is increasing and is projected to continue increasing for many years to come. Most of the increase will probably occur in cities and the extent of urban areas will increase with it. As cities grow larger and new cities are built, the many and diverse climatic effects of urbanization will become more evident. A specific climatic effect of urbanization which has not receive
