Filetype
The recent randomized controlled phase III CLEAR trial results are the last to complement immune checkpoint inhibitor (ICI)-based doublet combination therapies for treatment-naïve metastatic clear-cell renal cell carcinoma. The CLEAR trial demonstrated an improved progression-free survival (PFS), overall survival (OS), and an objective response rate (ORR) benefit for the combination of lenvatinib
An increasing proportion of penicillin-susceptible Staphylococcus aureus (PSSA) has been reported over the last years. The aim of this retrospective study was to compare penicillin G with cloxacillin in the treatment of PSSA bloodstream infections. The primary outcome was the mortality rate after 90 days and the secondary outcome was the development of treatment complications of varying severity.
It is widely known that the time to treatment is vital for patients who suffer from a stroke. Therefore, in different places in the world, the value of acquiring mobile stroke units has been identified. A mobile stroke unit is a specially developed ambulance for stroke treatment, which has special equipment and trained personnel who can perform intravenous stroke treatment (thrombolysis). It is cl
Purpose: Octreotide SC depot is a novel, ready-to-use formulation administered via a thin needle. In a phase 1 study in healthy volunteers, this formulation provided higher bioavailability of octreotide with faster onset and stronger suppression of IGF-1 in healthy volunteers versus long-acting intramuscular (IM) octreotide. This phase 2 study evaluated the pharmacokinetics, efficacy, and safety o
More than 50 irregular satellites revolve around Jupiter and more than 30 around Saturn. There, at least three collisional families were identified. Among these, the Himalia family of prograde irregular moons at Jupiter is characterised by a velocity dispersion of several hundred m/s, inconsistent with a collisional origin (Nesvorný et al., 2003). Here we investigate whether the dispersion could s
Aims: The aim of this study was to estimate the self-reported domestic incidence of acute gastrointestinal illness in the Swedish population irrespective of route of transmission or type of pathogen causing the disease. Previous studies in Sweden have primarily focused on incidence of acute gastrointestinal illness related to consumption of contaminated food and drinking water. Methods: In May 200
This report presents the sixth version of the European Grassland Butterfly Indicator, one of the EU biodiversity indicators of the European Environment Agency.The indicator is based on more than 9200 transects in national Butterfly Monitoring Schemes covering 22 countries across Europe, most of them active in the European Union. In 2015, counts were made in more than 4500 transects.Butterflies rep
Based on measurements of a vertical nanowire InAs/GaAsSb/GaSb tunneling field-effect transistor (TFET) that exhibited minimum subthreshold swing of 48 mV/dec and a record high I60 of 0.31 μA/μm, a SPICE model has been generated to allow an experimentally-based prediction of the nanowire TFET technology. At 30 GHz the detector has been simulated to reveal a sensitivity of 4.8 kV/W biased near zero
BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be liv
Popular Abstract in Swedish Egenskaperna hos de material som utgör och omger oss, som t.ex. färg, struktur och kemiska egenskaper, bestäms av hur elektronerna som är en del av dess byggstenar, atomerna, är strukturerade. Ett sätt att undersöka elektronstrukturen är med hjälp den fotoelektriska effekten. Ljus, elektromagnetiska fält, kan beskrivas som en ström av ljuspartiklar, fotoner, som alla bäThe interaction between an intense laser pulse and a gas medium leads to the emission of coherent bursts of light in the extreme ultraviolet range. This process, known as high-order harmonic generation, has today, almost three decades after its discovery, developed into a reliable source of extremely short (on the order of 100 as) pulses of electromagnetic radiation, with a wide range of applicati
Associations are not random. Semantic memory is structured in a way that when hearing a category name a listener will automatically think of exemplars belonging to this category. The order in which exemplars come to mind and the frequency of retrieval of exemplars across individuals are measures of category-exemplar associative strength. Associative strength affects a broad range of psychological
The field of wireless communication is growing rapidly, with new requirements for the next generation of mobile and wireless communications technology. In order to achieve the capacities needed for future wireless systems, the design and implementation of advanced communications techniques such as multiantenna systems is required. These systems are realized by computationally complex algorithms, r
Autoignition in SI engines is an abnormal combustion mode and may lead to engine knock in SI engines. Knock may cause damage and it is a source of noise in engines. It limits the compression ratio of the engine and a low compression ratio means low fuel conversion efficiency of the engine. In this paper a multi zone model based on an existing two zone model Hajireza et al., [1 and 12] and Stenlaas
OBJECTIVE: Investigate the relationship between changes in lower limb EMG root mean square (RMS) activity and changes in body movement during perturbed standing. Specifically, linear movement variance, torque variance and body posture were correlated against tibialis anterior and gastrocnemius RMS EMG activity during perturbed standing by vibration of the calf muscles. METHODS: Eighteen healthy pa
A number of non-EU members – or third states – have chosen to participate in EU CSDP operations. This thesis seeks to answer why one of them, Iceland, has chosen to do so despite not being a member of the Union and not having any armed forces which are traditionally used in such activities. States have various motivations for participating in international crisis management operations and the same
In this thesis we study analytical and numerical methods which describe interactions and evolution of complex physical systems modeled by microscopic processes. We focus on two types of systems which are differentiated based on how modeling is taking place at the microscopic level. In that respect we study systems which can be described either by stochastic differential equations or by elementary
In this field study it is examined how the new Kenyan constitution, approved in 2010, has affected conflicts related to land. The study is based on a combination of quantitative data, conducted through standardized interviews with 90 people living in areas affected by land disputes, and qualitative data, gathered through deep-interviews with seven policy experts, all being differently involved in
