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Lung cancer is a common cancer type associated with poor prognosis. Even in the group of patients with earlystage tumors, for which curative treatment is possible, lung cancer recurrence is frequent. The aim of this thesis was to investigate the potential prognostic role of mutations in tumor specimens, blood-based proteins and circulating tumor DNA.In study I, we performed EGFR mutation detection

Objective: To investigate the causal role of cardiometabolic risk factors in osteoarthritis (OA) using associated genetic variants. Methods: We studied 27,691 adults from the Malmö Diet and Cancer Study (MDCS) and replicated novel findings among 376,435 adults from the UK Biobank. Trait-specific polygenic risk scores for low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol

Background The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were "negative to 14 HPV types" and in a mixed population of HPV-exposed and -unexposed women (intention-to-treat group). Methods This analysis studied

OBJECTIVE: To study intra-aneurysm sac pressure and subsequent abdominal aortic aneurysm (AAA) diameter changes in patients without endoleaks that remain unchanged in AAA diameter more than 1 year after endovascular aneurysm repair (EVAR). METHODS: A total of 23 patients underwent direct intra-aneurysm sac pressure (DISP) measurements 16 months (IQR: 14-35 months) after EVAR. Tip-pressure sensors

This article presents the results of a study where the effect of five window glazing types on daylight quality was investigated using a scale model (1:6) of a room with a single, south east-oriented window exposed to the natural sky. The space studied simulated a typical, fully furnished living room. A total of 30 research subjects took part in the experiment, observed the room and filled question

Alzheimer's disease researchers have been intrigued by the selective regional vulnerability of the brain to amyloid-β plaques and tau neurofibrillary tangles. Post-mortem studies indicate that in ageing and Alzheimer's disease tau tangles deposit early in the transentorhinal cortex, a region located in the anterior-temporal lobe that is critical for object memory. In contrast, amyloid-β pathology

The aim of this study is to contribute to the understanding of how gender constructions have been shaped and renegotiated in the modern history of the Church of Sweden. This is achieved through the dissertation’s two general approaches, which are to account for the establishment and development of the Swedish lay movement called the Brethren of the Church (Kyrkobröderna) up until women were allowe

Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence suggests that CRC should be considered a heterogeneous disease, with multiple differences between proximal and distal tumours. The immune system may, depending on the context, promote or inhibit tumour growth, and different immune cell subsets have been found to be associated with impaired or improved prognosis

GENERAL AIM: To investigate how common single-nucleotide-polymorphisms (SNPs) that associate with cardiovascular disease (CVD) could be used in prevention and treatment of CVD. SUBJECTS: Subjects from the population-based Malmö-Diet-and-Cancer-(MDC)-Study (n=30447) and hypertensives from the Nordic-Diltiazem-(NORDIL)-Study (n=10881). METHODS AND RESULTS: A nine-SNP-lipid-genetic-risk-score was r

Peak aerobic power in humans ((V) over dot(O2), peak) is markedly affected by inspired O-2 tension (F-IO2). The question to be answered in this study is what factor plays a major role in the limitation of muscle peak. (V) over dot(O2) in hypoxia: arterial O-2 partial pressure (P-a,(O2)) or O-2 content (C-a,C-O2)? Thus, cardiac output (dye dilution with Cardio-green), leg blood flow (thermodilution

Blue straggler stars (BSSs) are exotic stellar objects that appear to be younger than the age of the population they come from suggests. They are observed as the extension of the main sequence stars, beyond the turn-off point. They are present in all types of stellar populations, such as open clusters, globular clusters, dwarf galaxies, and even in the open field. It is believed that they form mai

Thermo Fisher Scientific manufacture automatic pipetting instruments for diagnostic tests. These tests are sensitive to abnormalities and changes in e.g. volume or density could potentially lead to less precision or other issues in the pipetting work flow. Utilizing data collected from a pressure sensor inside the pipette could be a way of automatically verifying different aspects related to the p

Ensamkommande unga som flyr undan krig eller förföljelse i sitt hemland möts i det nya landet av en migrationsprocess där åldern är central för prövningen av uppehållstillstånd. Anledningarna till det är flera. Bland annat tillerkänns personer under 18 år bostad, utbildning och sjukvård. Är den av sökanden påstådda åldern tveksam startar en åldersbedömning för att utreda om han eller hon är ett baUnaccompanied children who are fleeing war or persecution in their native country meet in the new country a migration process where the age is central for the legal examination of residence permit. The reasons for this are several. Among other things, individuals younger than eighteen are granted housing, education and medical care. If the age that the applicant claims is doubtful, an age assessme

In today’s connected world, businesses are increasingly going online. Additionally, the online industry is transforming into an international business arena, flourishing with opportunities to grow and expand. However, the internationalisation has raised a number of challenging issues. One of these challenges is foreign exchange. Foreign exchange is needed to sell and buy on markets with different

MAX-lab is a national synchrotron radiation facility in Lund. Nowadays, the MAX project consist of three facilities (three storage rings). A new storage ring is needed to improve material science, such as nanotechnology. MAX IV, also in Lund, will be 100 times more efficient than already existing synchrotron radiation facilities. The storage ring is controlled by a large number of magnets that are

Abstract—This article have been written in cooperation with The Swedish Defense Research Agency (FOI). The article proposes a method to calibrate hydrophone positions for improved underwater survailence in The Baltic Sea. The idea with the method is to use the sound of a powerboat and a novel beamforming algorithm for array element localisation (AEL). There are strategic military advatages to this

The release of carbon dioxide (CO2) from inland waters plays an important role in the global carbon cycle. Yet, there are uncertainties related to estimating riverine CO2 evasion (FCO2), especially in data scarce regions such as the Tibetan Plateau. It is unclear how global change in the form of climate warming and anthropogenic disturbance affects emissions. This study reports annual CO2 fluxes a

In an urbanizing world, challenged by climate change and rising temperatures, street vegetation can help mitigate urban temperatures. However, scaling the understanding of street vegetation’s cooling effects from local observations to the city level introduces challenges. While several studies have assessed the influence of street greenery on land surface temperature (LST) at the city scale using

Importance: The concept of embolic stroke of undetermined source (ESUS) unifies a subgroup of cryptogenic strokes based on neuroimaging, a defined minimum set of diagnostic tests, and exclusion of certain causes. Despite an annual stroke recurrence rate of 5%, little is known about the etiology underlying recurrent stroke after ESUS. Objective: To identify the stroke subtype of recurrent ischemic

Aims/hypothesis: The risk of complications and medical consequences of type 2 diabetes are well known. Hospital costs have been identified as a key driver of total costs in studies of the economic burden of type 2 diabetes. Less evidence has been generated on the impact of individual diabetic complications on the overall societal burden. The objective of this study was to analyse costs of hospital