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Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proChronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies pro

Popular Abstract in English Proteins are a big biological molecules that help cells to function. Proteins play important roles in all vital processes of the living cell, transporting molecules, speeding up chemical reactions, supporting structure of other proteins and the cell, helping the cell to move. Various disease-causing agents (e.g. bacteria and viruses) are constant threat to us. It is thMost drugs act on biomacromolecules. The Cost of developing new drugs is very high. A method to accurately predict binding affinities would be very useful. We have studied molecular mechanics with generalised Born and surface--area solvation (MM/GBSA) and alchemical free energy perturbation methods (FEP) for use in calculations of ligand binding energies. For the MM/GBSA method we have tested: Ca

Stress intensity factors are calculated for long plane cracks with one tip interacting with a region of graded material characteristics. The material outside the region is considered to be homogeneous. The analysis is based on assumed small differences in stiffness in the entire body. The linear extent of the body is assumed to be large compared with that of the graded region. The crack tip, inclu

Popular Abstract in Swedish De vetenskapliga bevisen för att högt blodkolesterol ökar risken för hjärtinfarkt medförde under 80-talet stort intresse för kolesterolsänkning både inom sjukvården och bland allmänheten. Syftet med avhandlingsarbetet var att studera hur läkare och patienter uppfattade och använde kunskaperna om högt blodkolesterol, och hur läkare och receptarier värderade sin egen och Scientific evidence of the causal relationship between high blood cholesterol and risk for coronary heart disease prompted extensive professional and public interest in practical application in the 1980's. Among other things, national guidelines for lipid lowering were published in Sweden in 1988. Mass media covered the topic extensively. The aims of this study were to analyze aspects of physician

Older adults are often portrayed as unwilling or unable to address quality issues in the formal care they receive. This study explores a methodology that captures the everyday reactions of older care users to quality problems, offering a nuanced understanding of their voice and agency when dissatisfied with care services. Using a telephone diary method, eight care users were contacted twice a week

The issue of dignity in the context of asylum seekers and their care has been widely discussed from various perspectives. As the rate of asylum-seeking increases, so too does the politics surrounding bare minimum standards. In the process of seeking asylum, individuals are increasingly forced to trade-off access to other rights. This study investigates the normative and human rights gaps in asylum

Purpose: To explore adaptation patterns among disability pensioners with musculoskeletal disorders returning to work by means of the Swedish law on 'resting disability pension'. Method: Qualitative analyses of interviews with 17 individuals going back to work. Results: Three adaptation patterns were identified: The Go- getter, the Realist and the Indifferent. These differed regarding influence facPurpose. To explore adaptation patterns among disability pensioners with musculoskeletal disorders returning to work by means of the Swedish law on ‘resting disability pension’.Method. Qualitative analyses of interviews with 17 individuals going back to work.Results. Three adaptation patterns were identified: The Go-getter, the Realist and the Indifferent. These differed regarding influence factor

The aim of this paper is to provide insights into, and perspectives on, the transformation of mindsets for logisticians. We argue that by exploring paradoxes inherent in the efficiency-focused paradigm of today, a strategic mindset can emerge in which central logistics management issues can be addressed, understood, and dealt with in order to enhance supply chain effectiveness and innovation. Base

Le Poidevin’s ‘new agnosticism’ concerns partaking in religious life while being uncertain whether religious discourse is fictional or not. Le Poidevin has offered two distinct versions of the new agnosticism, ‘semantic agnosticism’ and ‘meta-linguistic agnosticism’. I suggest that the first, ‘semantic agnosticism’, should be rejected, mainly because it involves a highly questionable view of truth

The pending ecological crisis has ushered in a need to rethink how electricity is produced and consumed, which in turn will require new ways of maintaining system balance. One solution that has gained traction over the past decade is the idea of user flexibility. User flexibility is by some deemed integral to the transition towards a low-carbon society and to the decarbonization agenda, and its inThe pending ecological crisis has ushered in a need to rethink how electricity is produced andconsumed, which in turn will require new ways of maintaining system balance. One solution that hasgained traction over the past decade is the idea of user flexibility. User flexibility is by some deemedintegral to the transition towards a low-carbon society and to the decarbonization agenda, and itsintegr

Vision provides important sensory input to postural control. Medical conditions and aging affect sensory—Central Nervous System (CNS) interactions, causing mismatches. Virtual Reality (VR) may address these by promoting recalibration from vision to other systems. Twenty-eight young adults (17 males, mean age 25.3 years) and 25 older adults (14 males, mean age 74.8 years) were included. Electromyog

1. The ability to resist infection is an important component of survival and lifetime reproductive success. Mounting and maintaining an immunological defence is assumed to be energetically costly and nutritional resources expended on immune function may induce trade-offs with other energetically expensive functions, including reproduction. Resource limitation may even have transgenerational effect

The MM500 meta-study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In thi

In the chapter the authors revisit one of the original topics in business angel research: to measure the scope of the business angel market and evaluate its impact on the economy, especially the financial contributions of business angels at the macro (market) level. This is an issue that has considerable policy relevance. Most policy initiatives to support business angel activities have been intro

This piece considers how we can think critically around prenatal sex selection and the problem of ‘missing girls’ and devise strategies to address this phenomenon without risk of harming the rights and interests of girls and women. To address the problem of ‘missing girls’ our research findings suggest there is a need to move beyond a rights-based approach towards gender and reproductive justice,

The accuracy of NOAA AVHRR NDVI maximum value composites can be poor due to interference from several sources, including cloud cover. The objectives of this paper are; 1. to accurately quantify noise in this imagery over Africa using geostatistics, and 2. to test four compositing techniques that may be able to reduce this noise. The nugget of the variogram model is used to compute standardized noi

Background: Chlamydia trachomatis is the most common cause of sexually transmitted infections globally and the leading cause of preventable blindness in the developing world. There are two biovariants of C trachomatis: 'trachoma', causing ocular and genital tract infections, and the invasive 'lymphogranuloma venereum' strains. Recently, a new variant of the genital tract C trachomatis emerged in S

The possibility of using radio over fiber (RoF) analog transmissions to characterize the wireless propagation channel of distributed antenna systems is investigated. In particular, the coherence time of kilometer-long, fiber-based networks is analyzed. Joint measurements of the phase noise of parallel links to the same site (intra-site) and to different sites (inter-site) in such a network are pre