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Popular Abstract in Swedish De allra flesta människor har vid något tillfälle tagit ett läkemedel. Till exempel vaccineras nu för tiden alla svenska barn mot bland annat stelkramp. Vad nog de allra flesta däremot inte har gjort är att fundera på vad ett läkemedel är. Kanske sträcker man sig till att ha kollat upp ett läkemedel i FASS, och kanske får man då syn på en figur som består av streck och A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. In a series of 15 papers, we have tested, compared, and improved the most p

In this paper, we consider precoder design for multiuser multiple-input-multiple-output (MIMO) Gaussian broadcast (BC) channels and propose a generalized zero-forcing (GZF) precoder based on successive dirty-paper coding (DPC), i.e., the GZF-DP precoder. The GZF-DP precoder is an extension of the GZF-DP precoder designed earlier for multi-input-single-output broadcast (MISO-BC) channels, and also

We have identified a new cyclic-nucleotide phosphodiesterase isoform, PDE3A, and cloned its cDNA from cultured aortic myocytes. The nucleotide sequence of its coding region is similar to that of the previously cloned myocardial isoform except for the absence of the initial 300-400 nt that are present in the latter, as confirmed by reverse-transcriptase-mediated PCR, 5' rapid amplification of cDNA

The hard x-ray scanning microscope at beamline P06 of PETRA III at DESY in Hamburg serves a large user community, from physics, chemistry, and nanotechnology to the bio-medical, materials, environmental, and geosciences. It has been in user operation since 2012, and is mainly based on nanofocusing refractive x-ray lenses. Using refractive optics, nearly Gaussian-limited nanobeams in the range from

Cardiovascular diseases are among the most important causes of death in thedeveloped countries. These diseases are partly caused by too high cholesterolconcentrations in the blood. Avena sativa, oat, is the most common spieces of the genus Avena, and produced in huge amounts worldwide. Oats have been shown to have cholesterol-lowering properties since the 1960s. This property was originally attrib

Studies suggest that skin cancer aggregates within families; however, the risk of skin cancer associated with having an affected sibling or parent by subtype, tumor site, and age at diagnosis has not been established. The 2006 update of the Swedish Family-Cancer Database was used to calculate standardized incidence ratios (SIRs), representing the ratio of cancer risk among individuals with affecte

Following the recent detection of an auroral signal on Uranus (Lamy et al. [2012]. Geophys. Res. Lett. 39, 7105) during HST/STIS observation performed in November 2011, we analyzed the associated HST/STIS FUV spectral images obtained in 2011 and 2012. Our purpose was to extract any possible H2 emission produced in the upper atmosphere of the planet. To interpret these data, we adapted a version of

We determine the properties of the binary star V106 in the old open cluster NGC6791. We identify the system to be a blue straggler cluster member by using a combination of groundbased and Kepler photometry and multi-epoch spectroscopy. The properties of the primary component are found to be Mp ~ 1.67M⊙, more massive than the cluster turn-off, with Rp ~ 1.91R⊙ and Teff = 7110 ± 100 K. The secondary

Purpose: To explore adaptation patterns among disability pensioners with musculoskeletal disorders returning to work by means of the Swedish law on 'resting disability pension'. Method: Qualitative analyses of interviews with 17 individuals going back to work. Results: Three adaptation patterns were identified: The Go- getter, the Realist and the Indifferent. These differed regarding influence facPurpose. To explore adaptation patterns among disability pensioners with musculoskeletal disorders returning to work by means of the Swedish law on ‘resting disability pension’.Method. Qualitative analyses of interviews with 17 individuals going back to work.Results. Three adaptation patterns were identified: The Go-getter, the Realist and the Indifferent. These differed regarding influence factor

Genome editing has proven to be highly potent in the generation of functional gene knockouts in dividing cells. In the CNS however, efficient technologies to repair sequences are yet to materialize. Reprogramming on the mRNA level is an attractive alternative as it provides means to perform in situ editing of coding sequences without nuclease dependency. Furthermore, de novo sequences can be inser

Strengthening of load-bearing masonry walls might often be a solution to extend the life cycle and area of use of existing buildings. In the present work, strengthening of masonry walls by means of externally bonded steel-grid is studied. Full scale clay brick masonry walls were constructed and tested in laboratory under eccentric axial compressive loading. By use of a steel-grid embedded in the rStrengthening of load-bearing masonry walls might often be a solution to extend the life cycle and area of use of existing buildings. In the present work, strengthening of masonry walls by means of externally bonded steel-grid is studied. Full scale clay brick masonry walls were constructed and tested in laboratory under eccentric axial compressive loading. By use of a steel-grid embedded in the r

Collective harm cases are situations in which things will become worse if enough acts of a certain kind are performed but no single act of the relevant kind will make a difference to the outcome. The inefficacy argument says that since one such act does not make a difference to the outcome, you have no outcome-related reason to refrain from acting in this way. If this argument holds, you have no cCollective harm cases are situations in which things will become worse if enough acts of a certain kind are performed but no single act of the relevant kind will make a difference to the outcome. The inefficacy argument says that since one such act does not make a difference to the outcome, you have no outcome-related reason to refrain from acting in this way. If this argument holds, you have no c

Fracture Liaison Services are the best model to prevent secondary fractures. The International Osteoporosis Foundation developed a Best Practice Framework to provide a quality benchmark. After a year of implementation, we confirmed that a single framework with set criteria is able to benchmark services across healthcare systems worldwide. Introduction Despite evidence for the clinical effectivenes

This qualitative study explores how communication practice affects Swedish home care nurses’ psychosocial work environ-ment. Data consisted of interviews and field observations, analyzed from the perspective of Media Synchronicity Theoryand the Job-Demand-Control-Support model. Individual home care nurses were found to manage an interorganizationalcommunication web. The results indicated that thisThis qualitative study explores how communication practice affects Swedish home care nurses’ psychosocial work environment. Data consisted of interviews and field observations, analyzed from the perspective of Media Synchronicity Theory and the Job-Demand-Control-Support model. Individual home care nurses were found to manage an interorganizational communication web. The results indicated that thi

Snapshot spectral imaging enables the acquisition of hyperspectral images (HSI) employing specialized optical systems, such as the coded aperture snapshot spectral imager (CASSI). Specifically, the CASSI system performs spatiospectral codification of light obtaining two-dimensional projected measurements, and these measurements are then processed by computational algorithms to obtain the desired s

Kinetic thermal degradation models are vital components for optimization of food and bioproducts processing. Typically, models are fitted to laboratory-scale experiments where vials are heated and held. However, these conditions are highly dissimilar from the thermal processes experienced in industrial production. Whereas fitting kinetic data to industrial-scale production is often impossible due

Sustainability science (SS) is diverse field of problem-driven and solution-oriented research that is still developing. The further maturation of the field relies on its practitioners formulating alternative paradigms to use-inspired knowledge production to facilitate comparison and reasoned judgment on what constitutes scientific best practices. In this short article, we flag several blind spots