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Viral vector-mediated gene transfer utilizing adeno-associated viral vectors has recently entered clinical testing as a novel tool for delivery of therapeutic agents to the brain. Clinical trials in Parkinson's disease using adeno-associated viral vector-based gene therapy have shown the safety of the approach. Further efforts in this area will show if gene-based approaches can rival the therapeut
Background: Computed tomography (CT) of the brain is performed with high local doses due to high demands on low contrast resolution. Advanced algorithms for noise reduction might be able to preserve critical image information when reducing radiation dose.PurposeTo evaluate the effect of advanced noise filtering on image quality in brain CT acquired with reduced radiation dose. Material and Method
Popular Abstract in Swedish Transporter är viktiga för ett fungerande samhälle, men samtidigt innehåller avgaserna från en förbränningsmotor farliga utsläpp som förorenar vår miljö. Kan vi på något sätt hindra att miljön blir förstörd av farliga utsläpp genom förbättrad motordesign? Frågan om global uppvärmning har varit vid liv enda sedan IPCC (Intergovernmental Panel on Climate Change) grundadeThis thesis concerns a numerical investigation on heat transfer in internal combustion engines, with the aim of increasing engine efficiency. The efficiency gains are to be extracted from reduced heat transfer losses, by increasing the knowledge on how the heat transfer process is affected by various hardware and operational parameters in the engine. The engines concerned are both conventional die
The main purpose of this qualitative study was to achieve better understanding in terms of staff officer’s notions about work-related bullying and interventions. There were two issues. The first one was what are the general performances on the phenomenon of bullying in the workplace? The second question was what are the performances about interventions? Seven personnel officers from Sweden were th
Aim A key component of library management is meeting the needs of our users. This requires continuous analysis of user experience followed by library development. The aim of this study was to better understand the use and effect of general user surveys (GUS) and other methods of gathering user input for quality assessment and improvement of library activities. Methods Data collection was done via
Popular Abstract in Swedish Jätteplaneterna, Jupiter, Saturnus, Uranus och Neptunus, är de största planeterna i solsystemet. De ligger långt från solen och har alla betydande gasatmosfärer, upp emot hundra gånger mer massiva än hela jorden. Tack vare de tjocka gashöljena, med en sammansättning som liknar solens, kan man förstå att jätteplaneterna bildades i en gasskiva. Denna skiva kallas för solGiant planets form embedded in a protoplanetary disc around a young star. Close to the midplane a large fraction of the available mass in solids is found in particles of cm to dm in size, which drift towards the star due to friction with the surrounding gas. In paper I, II, III we describe a novel theory that explains how embryos, planetesimals larger than ~1000 km, grow efficiently by sweeping up
Genuine forms of participation of the local people are integral to the success of government development projects implemented to curtail escalating insurgency against the State in the restive southern borders provinces of Thailand. This thesis aims to determine the form of participation that has manifested itself and the mechanisms of power that shape its parameters, given the centralized and hier
Background: A prediction model that estimates survival and neurological outcome in out-of-hospital cardiac arrest patients has the potential to improve clinical management in emergency rooms. Methods: We used the Swedish Registry for Cardiopulmonary Resuscitation to study all out-of-hospital cardiac arrest (OHCA) cases in Sweden from 2010 to 2020. We had 393 candidate predictors describing the cir
The dynamic interaction between a non-viscid, compressible fluid and an elastic structure is studied. Finite element formulations, using the weighted residual method, are derived. Different primary variables in the fluid domain are used and different source functions are considered.When a potential field is used, the dynamic interaction between fluid and structure yields nonsymmetric matrices. In The dynamic interaction between non-viscid, compressible fluid and an elastic structure is studied. Finte element formulations, using the weighted residual method, are derived. Different primary variables in the fluid domain are used and different source functions are considered.When a potential field is used, the dynamic interaction between fluid and structure yields nonsymmetric matrices. I addi
The hippocampus is one of the most challenging brain regions for proton MR spectroscopy (MRS) applications. Moreover, quantification of J-coupled species such as myo-inositol (m-Ins) and glutamate + glutamine (Glx) is affected by the presence of macromolecular background. While long echo time (TE) MRS eliminates the macromolecules, it also decreases the m-Ins and Glx signal and, as a result, these
In Classical Athens, being at war was more common than peace. The military expenditures were correspondingly large. The main puzzle, however, is not financial, but where the Athenians found the multitude of rowers needed for their ships. It was not until the end of the Peloponnesian War that there were good reasons to use slaves as rowers. The Spartan occupation of Decelea in 413 BCE had profound
The United Nations is the arena for a renewed push to regulate transnational corporations (TNCs) and their supply chains. This article analyses the ongoing efforts of a multilateral organization to strengthen the human rights legal framework, especially the design choices posed by the treaty negotiations as well as the role of the UN Human Rights Council in the broader regulatory ecosystem around
Turbulent breakup in emulsification devices is a dynamic process. Small viscous drops undergo a sequence of oscillations before entering the monotonic deformation phase leading to breakup. The turbulence-interface interactions prior to reaching critical deformation are therefore essential for understanding and modeling breakup. This contribution uses numerical experiments to characterize the criti
Aim: To compare long-term effects of a systemic school-based intervention, Marte Meo and Coordination Meetings (MAC), targeting 3- to 12-year-old children display- ing disruptive behaviour problems (DBP) in preschool or school, and service as usual (SAU). In addition, to examine whether social status (SS) affected the outcomes. Methods: In a randomised controlled design, teachers' and parents' ratAim: To compare long-term effects of a systemic school-based intervention, Marte Meo and Coordination Meetings (MAC), targeting 3- to 12-year-old children display- ing disruptive behaviour problems (DBP) in preschool or school, and service as usual (SAU). In addition, to examine whether social status (SS) affected the outcomes. Methods: In a randomised controlled design, teachers' and parents' rat
I will show that what is respected the most in human reproduction and parenting is not a right to reproduce in the way in which this right is explicitly proposed. The only way in which people can become, and function as, parents without having to submit themselves to anyone else’s judgments and decisions, is by having reproductive sex. Whatever one’s intentions, social status, standard of living,
The objective of this study was to evaluate the influence of operational conditions and wastewater properties on the removal of pharmaceuticals, contrast media and antibiotics through ozonation, in order to facilitate the optimization of treatment and its implementation on a full scale. Pilot-scale ozone oxidation trials were performed on treated wastewater, before and after post-precipitation, ov
OBJECTIVE: To compare the outcomes of laparoscopic lavage and sigmoid resection in perforated diverticulitis with purulent peritonitis.BACKGROUND: Peritonitis secondary to perforated diverticulitis has conventionally been managed by resection and stoma formation. Case series have suggested that patients can be safely managed with laparoscopic lavage, resulting in reduced mortality and stoma format
