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Viral vector-mediated gene transfer utilizing adeno-associated viral vectors has recently entered clinical testing as a novel tool for delivery of therapeutic agents to the brain. Clinical trials in Parkinson's disease using adeno-associated viral vector-based gene therapy have shown the safety of the approach. Further efforts in this area will show if gene-based approaches can rival the therapeut
Objectives: To estimate seroprevalence of 11 high-risk (hr) HPV types and four low-risk (lr) HPV types among 20-64 years old Slovenian women participating in the population-based cervical cancer screening program. Methods: Serum samples from 3259 women were tested for HPV type-specific antibodies with a multiplexed pseudovirion-based serological assay (PsV-Luminex). Results: Seropositivity for any
Background: Computed tomography (CT) of the brain is performed with high local doses due to high demands on low contrast resolution. Advanced algorithms for noise reduction might be able to preserve critical image information when reducing radiation dose.PurposeTo evaluate the effect of advanced noise filtering on image quality in brain CT acquired with reduced radiation dose. Material and Method
Popular Abstract in Swedish Transporter är viktiga för ett fungerande samhälle, men samtidigt innehåller avgaserna från en förbränningsmotor farliga utsläpp som förorenar vår miljö. Kan vi på något sätt hindra att miljön blir förstörd av farliga utsläpp genom förbättrad motordesign? Frågan om global uppvärmning har varit vid liv enda sedan IPCC (Intergovernmental Panel on Climate Change) grundadeThis thesis concerns a numerical investigation on heat transfer in internal combustion engines, with the aim of increasing engine efficiency. The efficiency gains are to be extracted from reduced heat transfer losses, by increasing the knowledge on how the heat transfer process is affected by various hardware and operational parameters in the engine. The engines concerned are both conventional die
The aim of our study was to examine society‘s attitudes towards the causes of homelessness and to identify where the responsibility lies. We have compared the attitudes of men and women and also analysed our results from the perspective of stigma. We have conducted our study in a training facility using questionnaires. We have investigated what people believe is the reason why individuals become h
Aim A key component of library management is meeting the needs of our users. This requires continuous analysis of user experience followed by library development. The aim of this study was to better understand the use and effect of general user surveys (GUS) and other methods of gathering user input for quality assessment and improvement of library activities. Methods Data collection was done via
Popular Abstract in Swedish Jätteplaneterna, Jupiter, Saturnus, Uranus och Neptunus, är de största planeterna i solsystemet. De ligger långt från solen och har alla betydande gasatmosfärer, upp emot hundra gånger mer massiva än hela jorden. Tack vare de tjocka gashöljena, med en sammansättning som liknar solens, kan man förstå att jätteplaneterna bildades i en gasskiva. Denna skiva kallas för solGiant planets form embedded in a protoplanetary disc around a young star. Close to the midplane a large fraction of the available mass in solids is found in particles of cm to dm in size, which drift towards the star due to friction with the surrounding gas. In paper I, II, III we describe a novel theory that explains how embryos, planetesimals larger than ~1000 km, grow efficiently by sweeping up
Managua has experienced two devastating earthquakes during the last century resulting in major human loss. The destruction in the earthquake of 1972 was particularly severe in defined areas of the city, including the former city centre, which is now unused terrain. This may have been because of amplification in those areas due to impedance contrasts and resonance effects in the surface layers. Th
Background: A prediction model that estimates survival and neurological outcome in out-of-hospital cardiac arrest patients has the potential to improve clinical management in emergency rooms. Methods: We used the Swedish Registry for Cardiopulmonary Resuscitation to study all out-of-hospital cardiac arrest (OHCA) cases in Sweden from 2010 to 2020. We had 393 candidate predictors describing the cir
The dynamic interaction between a non-viscid, compressible fluid and an elastic structure is studied. Finite element formulations, using the weighted residual method, are derived. Different primary variables in the fluid domain are used and different source functions are considered.When a potential field is used, the dynamic interaction between fluid and structure yields nonsymmetric matrices. In The dynamic interaction between non-viscid, compressible fluid and an elastic structure is studied. Finte element formulations, using the weighted residual method, are derived. Different primary variables in the fluid domain are used and different source functions are considered.When a potential field is used, the dynamic interaction between fluid and structure yields nonsymmetric matrices. I addi
The hippocampus is one of the most challenging brain regions for proton MR spectroscopy (MRS) applications. Moreover, quantification of J-coupled species such as myo-inositol (m-Ins) and glutamate + glutamine (Glx) is affected by the presence of macromolecular background. While long echo time (TE) MRS eliminates the macromolecules, it also decreases the m-Ins and Glx signal and, as a result, these
Train delays are often monitored using lag indicators of achieved punctuality levels, but indicators can also be used proactively as lead indicators to help reach a certain level of punctuality. In this paper, two lead indicators – the share of delayed dwell times and the share of delayed run times – are formulated and tested on Swedish commuter train data for the years 2001-2020. Results show tha
The United Nations is the arena for a renewed push to regulate transnational corporations (TNCs) and their supply chains. This article analyses the ongoing efforts of a multilateral organization to strengthen the human rights legal framework, especially the design choices posed by the treaty negotiations as well as the role of the UN Human Rights Council in the broader regulatory ecosystem around
I will show that what is respected the most in human reproduction and parenting is not a right to reproduce in the way in which this right is explicitly proposed. The only way in which people can become, and function as, parents without having to submit themselves to anyone else’s judgments and decisions, is by having reproductive sex. Whatever one’s intentions, social status, standard of living,
The objective of this study was to evaluate the influence of operational conditions and wastewater properties on the removal of pharmaceuticals, contrast media and antibiotics through ozonation, in order to facilitate the optimization of treatment and its implementation on a full scale. Pilot-scale ozone oxidation trials were performed on treated wastewater, before and after post-precipitation, ov
OBJECTIVE: To compare the outcomes of laparoscopic lavage and sigmoid resection in perforated diverticulitis with purulent peritonitis.BACKGROUND: Peritonitis secondary to perforated diverticulitis has conventionally been managed by resection and stoma formation. Case series have suggested that patients can be safely managed with laparoscopic lavage, resulting in reduced mortality and stoma format
Aims: In the present study, we aimed to evaluate the performance of machine learning (ML) models for identification of acute myocardial infarction (AMI) or death within 30 days among emergency department (ED) chest pain patients. Methods and results: Using data from 9519 consecutive ED chest pain patients, we created ML models based on logistic regression or artificial neural networks. Model input
