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Introduction: Using time-limited trials of low-dose, sustained-release morphine to reduce chronic breathlessness to evaluate net effects may generate opioid withdrawal symptoms if medication is ceased. This sub-study of a larger randomized, placebo-controlled, double-blind trial aimed to evaluate if this occurred. Methods: People with modified Medical Research Council breathlessness scores of 3 or
Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. Methods and results A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European
This paper presents a statistical combination of searches targeting final states with two top quarks and invisible particles, characterised by the presence of zero, one or two leptons, at least one jet originating from a b-quark and missing transverse momentum. The analyses are searches for phenomena beyond the Standard Model consistent with the direct production of dark matter in pp collisions at
Responsibility to protect, eller R2P, är en norm inom FN som uppstod som en reaktion på många av de inomstatliga konflikter som pågick världen över under 90-talet. FN:s misslyckande med att skydda de civila som drabbades av humanitära katastrofer visade på ett behov av förändring gällande möjligheten att ingripa i inomstatliga konflikter. 2001 utkom en rapport från den kommission, ICISS, som tilResponsibility to protect, or R2P, is a norm within the UN that emerged as a reaction towards the many intrastate conflicts that occurred around the world during the 90’s. The UN’s failure to protect civilians from humanitarian disasters displayed a need for change regarding the opportunity to intervene during these types of conflicts. In 2001 the commission, ICISS, founded under the authority of
Purpose: Brain tumours constitute 25% of childhood neoplasms, and half of them are in the posterior fossa. Surgery is a fundamental component of therapy, because gross total resection is associated with a higher progression-free survival. Patients with residual tumour, progression of residual tumour or disease recurrence commonly require secondary surgery. We prospectively investigated the risk of
Objectives To assess whether recommendations of individually oriented lifestyle interventions (IOLIs) in guidelines from the National Institute for Health and Care Excellence (NICE) were underpinned by evidence of benefit, and whether harms and opportunity costs were considered.Design Cross sectional survey.Setting UK.Data sources NICE guidelines and supporting evidence.Eligibility criteria All NI
Adults with congenital heart disease (ACHD) are a completely new and rapidly growing specialty comprising patients who require specialist knowledge regarding their care and treatment. Challenges involve diagnostics and treatment as studies are scarce and include small and heterogenous study populations.The first aim with this thesis was to evaluate the relationship between the systemic right ventr
BackgroundOut-of-hospital cardiac arrest (OHCA) survivors generally report good health-related quality of life, but physical aspects of health seem more affected than other domains. Limitations in physical function after surviving OHCA have received little attention.AimsTo describe physical function 6 months after OHCA and compare it with a group of ST elevation myocardial infarction (STEMI) contr
The consumption and production of livestock have a negative impact on the environment and climate. In many Western countries, the consumption is particularly high and it is expected to increase globally. This increase will lead to further pressure on already stressed planetary boundaries. Recently edible insects have been proposed to be an alternative to conventional meat, because they have a lowe
Using agenda setting theory, I have conducted a content analysis of British local newspaper articles to analyze reports regarding the Munich Agreement, which was signed September 30th, 1938. The theory is based on the assumption that media "controls" the reality which is shared with the readers. In a pre-digital society, local media outlets had far greater influence over the public agend
Grooming är ett vedertaget begrepp för det tillvägagångssätt som förövare använder sig av för att ta kontakt med barn, ofta på internet, för att slutligen begå sexuella brott mot barnet. Internetets expansion har på många sätt gett förövare fler tillvägagångssätt att komma i kontakt med barn. En stor andel av barnen i Sverige använder sociala medier, varav många någon gång har blivit kontaktade onGrooming is an established word for the approach that perpetrators are using to contact children, oftentimes over the Internet, ultimately to commit sexual offenses against the child. The expansion of the Internet has in many ways made it easier for perpetrators to approach and contact children. The vast majority of Swedish children use social media, many of whom at some point have been contacted
In association with the refugee crisis in 2015, more people sought asylum in Sweden than ever before. The Swedish government initially pursued a relatively welcoming asylum policy with open borders and with a vision of maintaining the right to asylum. This moral attitude towards refugees would subsequently take a turn. On December 9 in 2015, the Bill "Specific measures during serious danger t
This paper examines social policy in the European Union with a specific focus on parental leave, in-cluding earmarked paternity leave. It traces the process of how the legislation of parental leave has gone through a process of Europeanization and through the decision-making process of the European Union, resulted in the Directive 2019/1158. Moreover, it aims at examining the Danish knowledge of t
I analyse the effect of risk aversion on the share of wealth investment on risky tradable financial assets at individual level by exploiting the results of a laboratory experiment on a sample of over 700 Dutch respondents. The estimates of an econometric model show that for different wealth levels, risk aversion has heterogeneous effects on the share of wealth invested in risky tradable financial
Abstract Purpose - The purpose of this study is to gain a deeper understanding of how employees, of the London Hilton on Park Lane hotel, make sense of organisational changes resulting from crisis management during the Covid-19 pandemic. We aim to contribute to the existing literature within the field of change and crisis management and build on Weick’s (1995) concept of sensemaking. Therefore, ou
We have made in-situ investigations of ultrathin films of Fe grown on a Ag(100) single crystal. This system is known to exhibit a reorientation of the magnetization, dependent on both Fe thickness and temperature. X-ray absorption fine structure has been recorded for samples prepared in-situ, both in the near edge and in the extended x-ray absorption fine structure (EXAFS) region. Using x-ray magn
Objective: Individual-based studies on restricted geographical settings have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may precipitate congestive heart failure. As NSAID use is very extensive, it might increase the occurrence of symptomatic heart failure in the general population. Therefore, in order to study the impact of NSAID utilisation (prescribed and over the counter) on h
Popular Abstract in Swedish Avhandlingen syftar till att undersöka arbetslöshetens sociala konsekvenser och försöka ge en rimlig tolkning av variationer i arbetslöshetserfarenheter med hjälp av en teoretisk modell - ekonomi-skam modellen. Fokus ligger på att söka lyfta fram och visa på betydelsen av ekonomiska påfrestningar i kombination med skamupplevelser som en faktor för att förstå skillnader The purpose of this study has been to investigate the social consequences of unemployment and to give a possible interpretation of unemployment experiences through the application of the economy-shame model. It intends to put forward and show the significance of economic stress in combination with the feeling of shame as a factor important for the understanding of differences in unemploy-ment expe
Breeding synchrony is hypothesised to influence the occurrence and frequency of extra-pair fertilisations (EPFs) in birds irrespective of the social mating system. The two proposed hypotheses make opposite predictions. (1) Synchronous breeding leads to a lower frequency of EPFs because males face a trade-off between mate guarding and obtaining additional matings via extra-pair copulations (EPCs) (
