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Purpose The AGO-OVAR 2.29/ENGOT-ov14/PENELOPE prospectively randomized phase III trial evaluated the addition of pertuzumab to chemotherapy in patients with platinum-resistant ovarian carcinoma with low tumor human epidermal growth factor receptor 3 (HER3)mRNA expression. We report the results of the primary efficacy analysis. Patients and Methods Eligible patients had ovarian carcinoma that progr
Elevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of mancozeb, in drinking water samples
Huntington's disease is a neurodegenerative disorder caused by an abnormal CAG repeat expansion within exon 1 of the huntingtin gene HTT. While several genetic modifiers, distinct from the Huntington's disease locus itself, have been identified as being linked to the clinical expression and progression of Huntington's disease, the exact molecular mechanisms driving its pathogenic cascade and clini
In this paper, I describe systems and prototypes we created in the natural language processing group at Lund to extract structured knowledge from text. Starting from syntactic and semantic parsingcomponents,wedevelopedapplicationsthatcanhandlelargecorpora,typicallycomplete Wikipedia versions consisting of millions of documents and process text to identify entities and the relations between them. I
Axonal injury is a hallmark of traumatic brain injury (TBI) and is associated with a poor clinical outcome. Following central nervous system injury, axons regenerate poorly, in part due to the presence of molecules associated with myelin that inhibit axonal outgrowth, including myelin-associated glycoprotein (MAG). The involvement of MAG in neurobehavioral deficits and tissue loss following experi
Purpose: Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults. Methods: This study includes 235,880 participants, 25–70 years old, recruited between 1992 and 2000 in 10 European countries. Intake
Introduction: Low aerobic fitness, low muscular strength, and obesity have been associated with premature mortality, but their interactive effects are unknown. This study examined interactions among these common, modifiable factors, to help inform more-effective preventive interventions. Methods: This national cohort study included all 1,547,478 military conscripts in Sweden during 1969-1997 (97%-
Foot problems complicating diabetes are a source of major patient suffering and societal costs. To prevent, or at least reduce, the adverse effects of foot problems in diabetes, the International Working Group on the Diabetic Foot (IWGDF; www.iwgdf.org) was founded in 1996, consisting of experts from almost all the disciplines involved in the care of patients with diabetes and foot problems. An im
This study presents a 2-yr follow-up of 281 patients, aged 15-34 yr, diagnosed with diabetes between 1992 and 1993. At diagnosis, 224 (80%) patients were positive for at least one of the following autoantibodies: islet cell antibodies (ICAs), glutamic acid decarboxylase antibodies (GADAs), or tyrosine phosphatase antibodies (IA-2As); the remaining 57 (20%) patients were negative for all three auto
Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most common. Patients with LS have an increased risk of early onset colon and endometrial cancer, but also other tumors that generally have an earlier onset compared to the general population. However, age at first primary cancer varies wit
BACKGROUND: Diabetes mellitus and hypertension are risk factors for cardiovascular disease, which is the most common cause of death in the world. People with intellectual disability (ID) have been reported to have high rates of both these disorders. The aim of this study was to describe and compare prevalence ratios of diabetes mellitus and hypertension between older adults with ID and their age p
Under åren har det riktats stark kritik mot det svenska nämndemannasystemet. Kritiken bottnar i att systemet inte anses uppfylla sitt syfte och istället motverkar sådana grundläggande värden som är nödvändiga i en demokratisk rättsstat. Uppsatsens syfte är således att utreda hur det svenska nämndemannasystemet förhåller sig till rättssäkerheten och att jämföra det svenska systemet med det danska lThrough the years, the Swedish lay judge system has faced a lot of criticism. The criticism is based on the perception that the system fails to fulfill its purpose and instead compromises fundamental values essential to a democratic state. The purpose of the essay is to examine how the Swedish lay judge system relates to the principle of legal certainty and to compare the Swedish system with the D
Thesis Purpose: The purpose of this study is to explore and develop an understanding of the rather unexplored phenomenon of using flagship stores in the FMCG industry. We want to explore what an FMCG flagship store is to understand why it is used in the context of strategic brand management. Moreover, we want to develop an understanding of how the brand experience might influence the consumer-bran
Increasing women’s participation in peace processes has been a multilateral goal since the UN Security Council adopted Resolution 1325 in 2000. This bachelor thesis explores the benefits and shortcomings of the implementation of The United Nations Security Council Resolution 1325 in Rwanda through a case study. The research question has therefore been phrased as following; What are the Benefits an
Climate change, the energy crisis of 2022-2023, and estimations of future electricity demands have stressed the necessity for a rapid transition of the energy system. Offshore wind energy plays an important role in this transition, and is expected to expand considerably on a global level, in the EU and in Sweden. While Swedes show high support of wind energy, a majority of recent projects have bee
The ability of thermoresponsive, amine-functionalized microgel particles to take part in microgelmicrogel inter-cross-linking has previously been reported in the literature, in connection to applications such as for example the formation of stimuli-responsive colloidal gels and colloidosomes [1]. This thesis deals with the synthesis of such thermoresponsive, cross-linkable microgels and their subs
In this report, a method was developed for quantitative validation of alternative fire protection designs. The report shows that uncertainties in calculations for fire protection and the fire protection devices in buildings are not often taken into account. If the method are used correctly it can serve as a guidance for quantitative validation of alternative fire protection. The method consists of
Communication today is not something merely taking place face to face, technology such as the internet and social media channels have opened up for endless interactions taking place in the online world. User generated content in the form of online travel reviews come with many challenges and opportunities for organizations. User generated content has been shown to impact a travelers decision in al
This thesis investigates the media discourse of the Swedish party Feminist Initiative in conjunction with the election to the European Parliament, and the general national election, in May and September 2014. Through the methods of narrative analysis and critical discourse analysis, it identifies the dominating media approaches and attitudes towards the party, and analyses what norms and structure
