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The major histocompatibility complex (MHC) is a membrane protein group of central importance in the immune system. It is divided into two main classes, class I and class II. The MHCs are highly polymorphic which is believed to be indication of trans-species polymorphism (TSP). There is TSP when an allele is maintained in two species through a speciation event. The songbirds that I study here belon
År 2006 trädde datalagringsdirektivet i kraft med två terrorattentat i Europa i bagaget. Syftet var att harmonisera medlemsstaternas lagstiftning gällande lagring av trafikuppgifter samt förenkla förebyggande och utredande av allvarlig brottslighet. De uppgifter som teleoperatörerna skulle lagra rörde vem som kommunicerade med vem, när och var det skedde samt vilken typ av kommunikation som användIn 2006, following the two terror attacks in Europe; the European Council adopted the Data Retention Directive. There were two primary reasons behind the legislation; most importantly to simplify the prevention and investigation of serious crimes in the union, but also to harmonise the legislation surrounding retention of data among the Member States. The directive obligated telecommunications ope
Vargen är en skyddad art i internationell rätt, EU-rätt och nationell rätt. Emellertid uppstår intressekonflikter på grund av de skador en stor vargstam kan orsaka. Syftet med denna uppsats är att belysa de mål för artskyddet, som ligger till grund för vargskyddet i respektive regelverk. Vidare åsyftas att belysa de inskränkningar som får göras i artskyddet, för att undersöka när motstående intresThe Swedish grey wolf is protected as an endangered species under international law, EU law and national legislation. However, because of damages that may occur from a large wolf population, certain conflicts of interest appear. The thesis of this essay is to explore the goals of species protection law, which provides the protection for the wolf in each legal framework. Furthermore, the essay expl
Den 1 juli 2018 fick Sverige en ny våldtäktslagstiftning. Den nya lagstiftningen innebar att rekvisitet som skiljer olagligt och lagligt sexuellt umgänge förändrades. I tidigare våldtäktslagstiftning har tvång varit en förutsättning för att en våldtäkt skulle anses förövad. Med den nya regleringen står nu frivillighet i centrum för denna bedömning. Lagändringen föregicks av mycket debatt. Det diskOn the 1st of July 2018 Sweden changed the law on sexual assault. The new law meant that the prerequisite that separate sexual assault and legal sexual intercourse was changed. In previous legislation coercion was needed for a perpetrator to be convicted of sexual assault. The new law instead places voluntariness at the center of the court’s assessment. The amendment was preceded by much debate. T
In Europe, annual influenza vaccination is recommended to elderly. From 2011 to 2014 and in 2015-16, we conducted a multicentre test negative case control study in hospitals of 11 European countries to measure influenza vaccine effectiveness (IVE) against laboratory confirmed hospitalised influenza among people aged ≥65years. We pooled four seasons data to measure IVE by past exposures to influenz
BACKGROUND/AIMS: The aim of this study was to develop a risk model for intraoperative complication (IC) during cataract surgery, defined as posterior capsule rupture and/or zonular dehiscence, and to include previous intravitreal therapy (pIVT) in the model.METHODS: This retrospective register-based study covered patients reported to the Swedish National Cataract Register (SNCR) between 1 January
Purpose: Presence of disseminated tumour cells (DTCs) in the bone marrow (BM) has been described as a surrogate of residual disease in patients with early breast cancer (EBC). PADDY (Pooled Analysis of DTC Detection in Early Breast Cancer) is a large international analysis of pooled data that aimed to assess the prognostic impact of DTCs in patients with EBC. Experimental design: Individual patien
Objectives: The aim of this study was to evaluate the short-term safety and efficacy of transcatheter aortic valve replacement (TAVR) with the LOTUS Edge system. Background: The LOTUS Edge system was commercially re-released in April 2019. The authors report the first European experience with this device. Methods: A multicenter, single-arm, retrospective registry was initiated to evaluate short-te
In the early stages of the building design process, during the programming andthe proposal stages, both user activities and the building are in focus for thedesigner. In spite of this, today’s CAD programs give no support formanagement of information about user activities in the building. This paperdiscusses the requirements on modelling user activities in the context ofbuilding design and presentIn the early stages of the building design process, during the programming and the proposal stages, both user activities and the building are in focus for the designer. In spite of this, today’s CAD programs give no support for management of information about user activities in the building. This paper discusses the requirements on modelling user activities in the context of building design and pr
Deoxygenation affects many continental shelf seas across the world today and results in increasing areas of hypoxia (dissolved oxygen concentration ([O2]) <1.4 ml/L). The Baltic Sea is increasingly affected by deoxygenation. Deoxygenation correlates with other environmental variables such as changing water temperature and salinity and is directly linked to ongoing global climate change. To place t
Pheromone production in the female turnip moth, Agrotis segetum, is under the control of a brain factor. This factor was demonstrated to be a proteinaceous substance termed pheromone biosynthesis activating neuropeptide‐like substance (PBAN‐like substance). The sex pheromone of Swedish A. segetum includes (Z)‐5‐decenyl acetate, (Z)‐7‐dodecenyl acetate, and (Z)‐9‐tetradecenyl acetate as major compo
This retrospective study sought to determine the safety and effectiveness of flecainide in children with normal hearts and those with congenital heart disease (CHD) or cardiomyopathy (CMO). Baseline and follow-up data at two pediatric cardiology sites were queried (2000–2015); a total of 175 patients (20 with CHD and two with CMO) receiving flecainide were assessed. When comparing patients with CH
Context.-The diagnostic distinction of pulmonary neuroendocrine (NE) tumors from non-small cell lung carcinomas (NSCLCs) is clinically relevant for prognostication and treatment. Diagnosis is based on morphology and immunohistochemical staining. Objective.-To determine the diagnostic value of insulinoma-associated protein 1 (INSM1), in comparison with established NE markers, in pulmonary tumors. D
Background: Supratentorial intracerebral haemorrhage (ICH) carries an excessive mortality and morbidity. Although surgical ICH treatment can be life-saving, the indications for surgery in larger cohorts of ICH patients are controversial and not well defined. We hypothesised that surgical indications vary substantially among neurosurgical centres in Sweden. Objective: In this nation-wide retrospect
In Part I, an electrification scheme was described and a simulation of an observed cold-based storm from the U.S. Great Plains was validated with electrical observations. Most charge in the storm was separated by rebounding collisions of secondary ice originating from prior graupel-snow collisions. In this Part II, sensitivity tests are performed with the control simulation (Part I) and influences
Background: Previous studies have suggested that targeting the site of latest mechanical activation of the left ventricle (LV) results in improved cardiac resynchronization therapy (CRT) outcomes. It is not known whether these benefits are sustained over medium-term follow-up. Objective: To assess the clinical outcome of imaging-guided LV lead position. Methods: We sought to assess the medium-term
Background: Reliable biomarkers of androgen activity in humans are lacking. The aim of this study was, therefore, to identify new protein markers of biological androgen activity and test their predictive value in relation to low vs normal testosterone values and some androgen deficiency linked pathologies. Methods: Blood samples from 30 healthy GnRH antagonist treated males were collected at three
Introduction: Cardiac resynchronization therapy (CRT) is an established treatment for heart failure in selected patients. However, current guideline indications do not accurately predict individual prognosis with CRT, and up to 30% are nonresponders. Previous studies have shown that QRS area reduction following CRT is associated with improved survival. This study evaluates the incremental value of
The elegant cyclist: Cycling, fashion and femininity in Swedish and Danish women’s magazines at the turn of the 20th century.At the turn of the 20th century the new sport of cycling was endowed with femininity in Scandinavian ladies’ magazines. An analysis of the magazines Idun, Svensk Damtidning, Damernes Blad and Hjemmet between 1890 and the 1910s show that both Swedish and Danish magazines appe
