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Hyaluronan is a free glycosaminoglycan which is abundant in the extracellular matrix of the developing brain. Although not covalently linked to any protein it can act as a backbone molecule forming aggregates with chondroitin sulfate proteoglycans of the lectican family and link proteins. Using neurocan-GFP as a direct histochemical probe we analyzed the distribution and organization of hyaluronan

1. To investigate further the release, localization and identity of a non-nitrergic mediator of smooth muscle relaxation in the female pig urethra, we studied the effects of drugs acting at alpha 2-adrenoceptors or K+ channels, the effects of capsaicin and chemical sympathectomy, and the actions of several transmitter candidates. 2. Electrical field stimulation (EFS; frequencies above 12 Hz) of sp

Heteroclitic monoclonal antibodies are characterized by the ability to bind multiple epitopes with little or no similarity. Such antibodies have been reported earlier, but insight into to the molecular basis of this propensity is limited. Here we report that the KIM185 antibody to human CD18 reacts with the plasma protein C4b-binding protein (C4BP). This was revealed during affinity purification p

Environmental and process control applications have needs for sensors that operate continuously or repeatedly, making them applicable to batch measurement and flowing product stream measurement. Additionally, for lactose monitoring in dairy-processing plants, the sensors must have sufficient flexibility to handle a wide range of substrate concentration and be resilient to withstand wide pH excursi

The present study elaborates on a 2D level set model of polycrystal microstructures that was recently established by adding the influence of anisotropic grain boundary energy and mobility on microstructure evolution. The new model is used to trace the evolution of grain boundary character distribution during grain growth. The employed level set formulation conveniently allows the grain boundary ch

OBJECTIVES:: In a recent study hypnosis has been found to relieve persistent idiopathic orofacial pain. Quantitative sensory testing (QST) is widely used to evaluate somatosensory sensitivity, which has been suggested as a possible predictor of management outcome. The objectives of this study were to examine: (1) possible associations between clinical pain relief and baseline somatosensory sensiti

The combination of glucagon and glucagon-like peptide-1 (GLP-1) has been suggested as an approach to target obesity, since the two hormones have complementary action on body weight. We examined whether complementary action of the two hormones also exist on insulin secretion. Female C57BL/6 mice were injected intravenously with glucose with or without GLP-1, glucagon or the combination of GLP-1 and

Populärvetenskaplig sammanfattning Geoelektriska mätningar med resistivitet och inducerad polarisation (IP) har traditionellt använts för att bland annat hitta berggrundsytor, kartera sprickighet och bedöma deponiers utbredning. Metoden utgår från olika materials olika elektriska egenskaper. I denna studie undersöktes möjligheten att hitta grundvattennivåerna i deponier med denna metod. Vattnet i There is a problem with leachate leakagein the Flishult landfill outside the town of Vetlanda . This means that water that has been in contact with the deposited material is likely to lead contaminants into the surrounding groundwater, causing an environmental impact on the surroundings. This problem is not unique to the Flishult landfill but can be found in many places where there are, e.g., wast

Denna uppsats belyser hur ett generationsskifte av enskild näringsverksamhet kan genomföras samt vilka problem och ställningstagande som parterna kan ställas inför. Ett generationsskifte innebär ofta efterföljande skattemässiga konsekvenser, varför både överlåtaren och mottagaren i så hög grad som möjligt strävar efter att mildra överlåtelsens ekonomiska påverkan även i det fortsatta livet. Detta This essay highlights how a generational shift of a sole trading company can be implemented and what problems and dilemmas the concerned parties may face. A generational shift often involves tax-related consequences whereby both the transferor and the receiver, as far as possible strive to minimize the economic impact of the handover even in daily life after the handover. This work clarifies the

Syftet med studien var att undersöka om deltagande i BUP Ystads multifamiljebehandling ledde till ett förbättrat samspel mellan barn och föräldrar. Vidare undersöktes om gruppen skiljde sig från en icke-klinisk grupp. I studien ingick 20 familjer som rekryterades från BUP Ystads familjemottagning. Huvudsymtomen hos barnen var beteendestörningar. En förälder per familj filmades tillsammans med sittThe purpose of the study is to investigate if the participation in the “BUP Ystad multi- family treatment” leads to a better level of interaction between parents and children. We also compared if there was any difference between this group and a non-clinical group. The study includes 20 families, recruited from BUP Ystad, whose main symptoms were behavior disorders among the children. One parent i

Sammanfattning Principen ne bis in idem är en grundläggande rättsstatsprincip som innebär ett förbud mot att straffas två gånger för samma brott. Principen kommer till uttryck i så väl intern svensk rätt som i internationella instrument som Sverige har anslutit sig till. Under de senaste åren har det förts en livlig diskussion kring det svenska systemet med skattebrott och skattetillägg och dess Summary The principle ne bis in idem is a fundamental right that protects individuals from being punished or tried twice for the same offence. The principle is expressed in both Swedish internal law and in several international instruments Sweden has chosen to join. Throughout the last couple of years there has been an intense discussion whether the Swedish system with punishment for tax offence

Familial risk of pancreatic cancer has been mainly assessed through case-control studies based on reported but not medically verified cancers in family members. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 21,000 pancreatic cancers to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for pancreatic cancer in 0- to 66-year-old

Background & Aims: Familial risks for esophageal cancer are not well known, especially for specific histologic types. Methods: We used the nationwide Swedish Family-Cancer Database to examine familial risks for esophageal cancer in offspring. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were used to calculate the risk. Age standardized incidence rates for specific hi

A set of concotto samples, a type of fired mixture of various raw materials, coming from firing place of the perifiuvial protohistoric site of Longola (Campania region, southern Italy) was characterized by means of a multi-analytical approach, i.e. polarized light optical microscopy (OM), X-ray powder diffraction (XRD), scanning electron microscopy and energy dispersive spectrometry (SEM-EDS), X-r

An abnormal nevus phenotype is associated with an increased risk of melanoma. We report a pooled analysis conducted using individual nevus data from 15 case-control studies (5,421 melanoma cases and 6,966 controls). The aims were to quantify the risk better and to determine whether relative risk is varied by latitude. Bayesian unconditional logistic random coefficients models were employed to stud

The main objective was to assess knowledge, practices, and restrictions faced by young women regarding their menstrual hygiene. The views of adult women having young daughters were also included and both views were compared. In addition, the factors influencing the menstrual hygiene practices were also studied. The study was carried out during 2008 in Mumbai, India. The mixed methods approach was

The crypt in Dalby as a batisterium – a digital reconstruction The article presents an example of the on-going research at Dalby in Scania, Sweden, focusing on the baptismal font and its original medieval context. The site and the current research are presented. Dalby was a medieval cathedral, Augustinian monastery and maybe also a royal manor. The crypt and font from the 12th C are presented. Th

We have explored the potential of cell factory-derived bioactive molecules, isolated from conditioned media of primary goat chondrocytes, for the repair of subchondral cartilage defects. Enzyme-linked immunosorbent assay (ELISA) confirms the presence of transforming growth factor-β1 in an isolated protein fraction (12.56 ± 1.15 ng/mg protein fraction). These bioactive molecules were used alone or

Semenogelin I and II (Sgl, Sgll) are two separate gene products of chromosome 20 with extensive (80%) identity in primary structure. They are mainly responsible for immediate gel formation of freshly ejaculated semen. Degradation of Sgl and Sgll is due to the proteolytic action of prostate-specific antigen (PSA); it results within 5-15 minutes in liquefaction of semen and release of progressively

OBJECTIVE: Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity.METHODS: In an investigator-initiated, double-blind, placebo-controlled clinical trial, non-di