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BaCON: A Google Chrome extension for sequence analysis

BaCON: Ett verktyg för bioinformatikern Bioinformatik är en tvärvetenskaplig disciplin, där datorberäkningar används för att analysera biologiska data. Inom området används många olika datorprogram, flera som en användare kan installera på sin egen dator. Många av dessa program går också att hitta online, med fördelar som att man slipper installera många program på sin egen dator och de använde

Den svenska mineralindustrins inställning till EU ETS

År 2005 började europeisk industri- och energiproduktion handla med utsläppsrätter i handelssystemet EU ETS. Tanken är att marknaden kommer minska koldioxidutsläppen där priset för utsläppsminskningar är lägst, och den Europeiska kommissionen beskriver EU ETS som ett nyskapande och kostnadseffektivt styrmedel. Men flera företag i mineralbranschen upplever utsläppshandeln som krångligt och orättvisThe European Union Emissions Trade System (EU ETS) is the central climate political tool for reduction of carbon dioxide emissions within the union, and is still the largest emissions trading system in the world ten years after the launch in 2005. One of the industry branches included in the system is the mineral branch: the production of cement, lime, glass, ceramics and mineral wool. These indus

Effects by adipocytes and obesity-associated metabolic conditions on phenotype and migration of breast cancer cells

Interactions between obesity and breast cancer Breast cancer and obesity are both diseases that are afflicting more and more women at an alarming rate in the Western world. In this project we examined how fat cells under different obesity-associated conditions, influenced breast cancer cells. We showed that breast cancer cells are affected by fat cells regarding both cell growth and movement. B

A Numerical Study of Injection Strategies for Zero-Carbon Compression Ignition Hydrogen Engines

This study investigates strategies for igniting hydrogen in compression ignition engines, a process traditionally hindered by hydrogen’s high ignition temperature. In conventional dual-fuel engines, a small diesel pilot is often used to ignite hydrogen, taking advantage of diesel’s lower ignition temperature to initiate combustion. While effective, this approach introduces carbon emissions, limiti

Distributive justice and the welfare state

Popular Abstract in Swedish Avhandlingen innehåller fyra artiklar som berör olika aspekter av offentlig omfördelning i välfärdsstaten. Avhandlingen syftar till att ge kunskap om konsekvenser av, motiv för och mätande av och denna omfördelning. Den första artikeln ställer frågan: Hög hög skatteomfördelning från arbetande till icke arbetande kan motiveras av grundantagandet att naturresurser är gemThis thesis is an attempt to generate knowledge about the justification, measurement and consequences of public redistribution. The first paper poses the following question: How much redistribution from working to non-working can be justified by arguing that external resources are owned jointly by all, or that ownership should ideally be divided equally? This question is analyzed using bargaining

Neural transplantation: restoring complex circuitry in the striatum

During the last 30 years, the promise of neural transplantation as a therapeutic strategy for neurodegenerative disease has been slowly recognised. Across the world, clinical transplants of embryonic primary dopamine neurones have been shown to ameliorate some of the motor deficits in Parkinson s disease (PD) patients, and more recently, systematic clinical trials have been initiated for the repla

Elevkårsengagerade ungdomars syn på skola, vänner, fritid och familj. Första delrapport, Projektet UNG

Stress, Unmanageability, FOMO, and Lack of Recovery: A New Perspective on Adolescent Mental HealthToday, many of the challenges that adolescents face involve mental health issues, some of which have the potential of negatively affecting them for a long time to come. There is, however, at present a lack of a detailed account on the mental health issues experienced by adolescents in Sweden. This stu

Lymphedema and Health-Related Quality of Life

Lymfödem är en svullnad som kan uppkomma i olika delar av kroppen. Svullnaden uppstår på grund av att lymfvätska inte hinner dräneras bort i tillräcklig takt, utan blir kvar i vävnaden. Orsaken kan vara en medfödd genetisk svaghet i lymfsystemet alternativt en skada på lymfsystemet orsakat av operation, infektion, inflammation eller annan kroppskada. Vanligast i Sverige är lymfödem i arm eller benThe overall aim of this thesis was to develop a lymphedema-specific instrument for measuring health-related quality of life (HRQoL) and to evaluate how persons with lymphedema experience HRQoL. Lymphedema is defined as swelling in one or more parts of the body that is due to impaired lymph drainage and transport. The impairments in the lymph system can be congenital or secondary to, e.g., cancer t

Sexual and functional long-term outcomes following advanced pelvic cancer and reconstruction using vertical rectus abdominis myocutaneous and gluteal myocutaneous flap

Introduction: After extensive pelvic surgery for cancer two flap types are used at Skåne University Hospital (SUS), Sweden for perineal reconstruction: vertical rectus abdominis myocutaneous flap and gluteal flap with or without vaginal reconstruction. The objective was to study the long-term outcomes in patients treated for advanced pelvic cancer receiving a flap. Method: Patients with pelvic can

Enabling new mindsets and transformative skills for negotiating and activating climate action : Lessons from UNFCCC conferences of the parties

Technological and policy solutions for transitioning to a fossil-free society exist, many countries could afford the transition, and rational arguments for rapid climate action abound. Yet effective action is still lacking. Dominant policy approaches have failed to generate action at anywhere near the rate, scale or depth needed to avoid potentially catastrophic futures. This is despite 30 years o

Preventing kidney injury among sugarcane workers : Promising evidence from enhanced workplace interventions

Objectives: To assess if improvement of working conditions related to heat stress was associated with improved kidney health outcomes among sugarcane harvest workers in Chichigalpa, Nicaragua, a region heavily affected by the epidemic of chronic kidney disease of non-traditional origin. Methods: Based on our findings during the 2017-2018 harvest (harvest 1), recommendations that enhanced the rest

Access to Health in Emergency Contexts: New Models of International Curriculum Development to Address Global Challenges

Capacity-building in international cooperation projects is typically founded on a conceptualisation of transmission or transfer, and thus also typically contributes to the international diffusion of certain models, systems or technologies. In European policy, this approach has been part of the strategy to strengthen the position of European HE by making HE structures in other parts of the world co

Group-Sparse Regression : With Applications in Spectral Analysis and Audio Signal Processing

This doctorate thesis focuses on sparse regression, a statistical modeling tool for selecting valuable predictors in underdetermined linear models. By imposing different constraints on the structure of the variable vector in the regression problem, one obtains estimates which have sparse supports, i.e., where only a few of the elements in the response variable have non-zero values. The thesis coll

User-related Assessment of the Traffic Jam Assist system of VCC

The aim of the user related assessment of the VCC demonstrator’s “Traffic Jam Assist” system was to study trust, usefulness, perceived advantages, disadvantages, acceptance, and willingness to pay for the driver assistance system. The system provides automated speed control and lane keeping. If a lead vehicle is present, the automated vehicle adapts its speed in order to maintain a pre-set time di

Staff ratings of occupational engagement among people with severe mental illness- psychometric properties of a screening tool in the day center context

Background: Staff who plan and organize day center activities may need to observe the attendees’ performance and progression. This led us to develop a tool for that purpose, termed General Occupational Engagement in people with Severe mental illness (GOES). The aim was to investigate its psychometric properties in terms of factor structure, internal consistency, corrected item-total correlations (

Expression of neutrophil SOD2 is reduced after lipopolysaccharide stimulation : A potential cause of neutrophil dysfunction in chronic kidney disease

Background. Neutrophils from patients with chronic kidney disease (CKD) are dysfunctional and thus a contributing factor to the risk of infections. The mechanisms for leucocyte dysfunction in CKD are not fully understood. It is known that lipopolysaccharide (LPS) activates transcription of several genes encoding proinflammatory cytokines. We therefore aimed to study the effect of LPS on neutrophil

Assessment and treatment of mental health problems in primary care : The course and results of Internet-based CBT and physical exercise on psychological functioning, stress and sleep

Psykisk ohälsa är en vanlig bakgrund till att patienter söker hjälp i primärvården men det är inte alltid dessa problem upptäcks. Patienterna erbjuds inte heller alltid adekvat behandling. Det finns flera väl beprövade bedömningsinstrument och evidensbaserade behandlingar för psykisk ohälsa men tillgängligheten till dessa är begränsad i primärvården. I avhandlingen ingår tre delstudier som är utfThe present thesis comprises three studies carried out within REGASSA, a multicenter randomized controlled trial in primary care. In the REGASSA study a 12 week treatment of mild to moderate depression and stress-related mental Health problems using Internet-based cognitive behavioural therapy (ICBT) and physical exercise (PE) was compared with treatment as usual (TAU). The inclusion criteria were

New, Useful Criteria for Assessing the Evidence of Infection in Sepsis Research

OBJECTIVES: The Sepsis-3 definition states the clinical criteria for sepsis but lacks clear definitions of the underlying infection. To address the lack of applicable definitions of infection for sepsis research, we propose new criteria, termed the Linder-Mellhammar criteria of infection (LMCI). The aim of this study was to validate these new infection criteria.DESIGN: A multicenter cohort study o

A comprehensive review of six dietary polyphenols in colorectal cancer : Pharmacokinetics, mechanism and therapeutic potentials

Background Colorectal cancer (CRC) remains a major global health challenge with high morbidity and mortality despite advances in detection and treatment. Dietary polyphenols are secondary metabolites widely found in plant-derived foods and beverages, and have gained attention for their potential in CRC prevention and therapy due to their diverse biological activities. Methods This review synthesiz

Prevention, Identification, Management and Long-Term Complications of Intracranial Haemorrhage in Children With Haemophilia and Other Severe Bleeding Disorders-A Practical Guidance

INTRODUCTION: Intracranial haemorrhage (ICH) is the most serious complication in infants and children with severe congenital bleeding disorders causing substantial mortality and long-term neurological morbidity. The neonatal period carries the highest risk, particularly in severe haemophilia and rare factor deficiencies. We review the epidemiology, risk factors, prevention, recognition, management