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Background: Research involving expressed sequence tags ( ESTs) is intricately coupled to the existence of large, well-annotated sequence repositories. Comparatively complete and satisfactory annotated public sequence libraries are, however, available only for a limited range of organisms, rendering the absence of sequences and gene structure information a tangible problem for those working with ta
A Course in Miracles (ACIM) is a spiritual teaching that was said to be channelled by Helen Shucman during 1965-1972. Shucman received what she described as an inner dictation, which she wrote down in shorthand. Her collegue and friend; William Thetford was then copy-typing the text. It came to comprise of around 1,200 pages of text, and is presented as a program of self-tuition, aimed to change a
Antibiotics are frequently administered orally to treat bacterial infections not necessarily related to the gastrointestinal system. This has adverse effects on the commensal gut microbial community, as it disrupts the intricate balance between specific bacterial groups within this ecosystem, potentially leading to dysbiosis. We hypothesized that modulation of community composition and function in
Background: In spite of considerable rice production gains over the past 50 years, Sub-Saharan Africa is becoming increasingly dependent on rice imports as demand is outpacing domestic supply. The serious economic and social strains caused by this have urged national leaders to address production deficits. The aim of this article is to analyse and discuss the drivers behind recent changes in rice
Drowning is a leading cause of accidental death. Survivors may sustain severe neurologic morbidity. There is negligible research specific to brain injury in drowning making current clinical management non-specific to this disorder. This review represents an evidence-based consensus effort to provide recommendations for management and investigation of the drowning victim. Epidemiology, brain-orient
Artikeln undersöker människors förhållningssätt till uppslagsverk och encyklopedier i ett livshistoriskt perspektiv under en period när encyklopedier har genomgått dramatiska förändringar. En frågelista som skickats till fasta så kallade meddelare knutna till Folklivsarkivet i Lund har använts som metod. Svaren har analyserats med hjälp av posthumanistisk teori. Analysen visar de sätt som tryckta Encyclopaedias are artefacts that both define and are defined by the culture in which they are produced and used. Encyclopaedias mirror the time of their creation, at the same time as understanding and use of encyclopaedias is tied to both time and space. From the 19th century until the present day encyclopaedias have changed from exclusive and costly Collections of books kept mainly in libraries
Increased vascular smooth muscle cell (VSMC) proliferation is a factor in atherosclerosis and injury-induced arterial (re)stenosis. Inhibition of polyamine synthesis by α-difluoro-methylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, attenuates VSMC proliferation with high sensitivity and specificity. However, cells can escape polyamine synthesis blockade by importing polya
Energy-efficient and cost-effective water desalination systems can significantly replenish freshwater reserves without further stressing limited energy resources. Currently, the majority of the desalination systems are operated by non-renewable energy sources such as fossil fuel power plants. The viability of any desalination process depends primarily on the type and amount of energy it utilizes a
This masters thesis deals with mathematical signal detection in the field of NQR,Nuclear Quadrapole Resonance, which is a non-invasive spectroscopic technique usedto identify specific substances. The thesis has two main focuses, where the first isto propose novel methods for parameter estimation, especially for identification ofunknown signals. These extend the existing Capon and APES methods for
Recent research on the Book of Psalms has been dealing intensively with issues relating to its so called “final shape." Proceeding from, among others, an influential dissertation by Gerald H Wilson, scholars have argued that the collection, as it now stands, is “more than the sum of its parts” (so e.g. McCann). Although such a notion is fairly straight forward on a conceptual or general level, it
Therapy directed against oncogenic FLT3 has been shown to induce response in patients with acute myeloid leukemia (AML), but these responses are almost always transient. To address the mechanism of FLT3 inhibitor resistance, we generated two resistant AML cell lines by sustained treatment with the FLT3 inhibitor sorafenib. Parental cell lines carry the FLT3-ITD (tandem duplication) mutation and ar
Popular Abstract in Swedish Nya möjligheter att förutsäga sjukdomsutvecklingen vid tidig ledgångsreumatism. I denna avhandling presenteras resultaten från sex studier av patienter med tidig reumatoid artrit (RA) – ledgångsreumatism. Syftet med avhandlingen var att i det tidiga sjukdomsskedet, så snart som möjligt efter diagnos, försöka skaffa information om hur sjukdomen kommer att utvecklas - om Objective: To investigate the role of magnetic resonance imaging (MRI), assessment of bone mineral density (BMD) and antibodies to citrullinated proteins (anti-CCP) in predicting radiologic outcome in patients with early rheumatoid arthritis (RA). Patients: All patients were included in the BARFOT programme (baseline). The patients had rheumatoid arthritis of recent onset with mean disease duratio
Much of the 1950–1970s building stock in Sweden and other European countries is being renovated to reduce energy use and for general upgrading. To realize the UN Sustainable Development Goals, the renovations should also improve indoor environmental quality (IEQ). The PEIRE (People-Environment-Indoor-Renovation-Energy) study followed the renovation of a multifamily housing area in Sweden comprisin
OBJECTIVE:: Multiple systematic reviews address the effect of antihypertensive treatment in people with diabetes. Here, we summarize current systematic reviews concerning antihypertensive treatment effect at different blood pressure (BP) levels, and relative treatment effect of different antihypertensive agents. METHODS:: We searched MEDLINE, BIOSIS, DARE and CDSR during years 2005–2016. Eligibili
Since the seriousness and urgency of climate change has surfaced during the last decade, researchers, experts, and even the pope have argued that dealing with it is a moral issue. However, emissions keep rising and it seems as if few people in the north are ready and willing to make any substantial lifestyle changes to minimize the potentially catastrophic consequences, mainly to the south. Intern
The increase in average global temperature and higherfrequency of heat waves predicted by the majority ofmeteorological models will increase the effect of heat stresson human beings. For specifically addressing the impact ofthis environmental health risk on individuals, improvedmethods including individual factors such as clothing andmetabolic rate are needed. This presentation gives anoverview of
Background and purpose — Cemented fixation is regarded as the gold standard in total knee arthroplasty (TKA). Among working-age patients, there has been controversy regarding the optimal fixation method in TKA. To address this issue, we conducted a register-based study to assess the survivorship of cemented, uncemented, hybrid, and inverse hybrid TKAs in patients aged < 65 years. Patients and meth
To address increasing climatic variability and extremes, cities are gradually forced to develop climate change adaptation strategies that can ensure a continuous and transformative adaptation process. There is widespread consensus that the sustainable establishment of such strategies requires transdisciplinary approaches, that is, the involvement of internal and external stakeholders (state, civil
