Filetype
Background: Serotonin (5-HT) is considered to play a role in pulmonary arterial hypertension by regulating vascular remodeling and smooth muscle contractility. Here, arteries from mice with inducible and smooth muscle-specific deletion of Dicer were used to address mechanisms by which microRNAs control 5-HT-induced contraction. Methods: Mice were used 5 weeks after Dicer deletion, and pulmonary ar
This work investigates the performance potential of an engine running with partially premixed combustion (PPC) using commercial diesel engine hardware. The engine was a 2.01 SAAB (GM) VGT turbocharged diesel engine and three different fuels were run - RON 70 gasoline, RON 95 Gasoline and MK1 diesel. With the standard hardware an operating range for PPC from idle at 1000 rpm up to a peak load of 10
UNLABELLED: To clarify the role of the TNFRSF11B gene encoding osteoprotegerin (OPG), in Paget's disease of bone (PDB) we studied TNFRSF11B polymorphisms in an association study of 690 UK subjects and in a worldwide familial study of 66 kindreds. We found that the G1181 allele of TNFRSF11B, encoding lysine at codon 3 of the OPG protein, predisposes to both sporadic and familial PDB.INTRODUCTION: P
AbstractObjectives: Patients with inflammatory rheumatic diseases (IRDs) have higher risk of serious infections than healthy individuals due to their illness, comorbidities and treatments. Streptococcus pneumoniae is responsible for 30-50% of community aquired pneumonia in Europe.The proportion of patients with IRD receiving vaccination against pneumococci is still estimated to be suboptimal. The
Melphalan at a dose of 200 mg/m2 is standard conditioning prior to autologous hematopoietic stem cell transplantation for multiple mulholger, but a dose of 140 mg/m2 is often used in clinical practice in patients perceived to be at risk of excess toxicity. To determine whether melphalan 200 mg/m2 and melphalan 140 mg/m2 are equally effective and tolerable in clinically relevant patient subgroups w
A paradigm shift is emerging in universities especially regarding how personalized and collaborative mobile learning should be addressed. Recently three international benchmarking projects on quality of e-learning in higher education have been carried out by Lund University in Sweden. These showed that quality has to be valued from a holistic perspective and to a higher extent from learning dimens
This book shows that the intensity of use of energy and materials in OECD countries is diminishing over time despite falling metal and energy prices. Material demand is sometimes falling in absolute terms, but there are also a few examples of rapid growth. The supply of fossil fuels and minerals is being exhausted, in some cases at a rapid speed, but the question addressed here is whether the rat
Inflammatory responses play a vital role at different stages of colorectal carcinogenesis. C-type lectins mediate inflammatory/immune responses and participate in immune escape of pathogens and tumors. Our study aimed to evaluate the correlation between polymorphisms in three C-type lectin genes, CD209, MBL2 and REG4, and colorectal cancer (CRC) risk and clinical outcome. We genotyped 15 potential
Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical pr
The spread of invasive pests is increasing due to greater global transportation and climate change-mediated range shifts. In a new community, these invasive species provide a novel resource that native predators or parasitoids can evolve to utilise. For invasive agricultural pests, this could provide top-down control; however, initial attack rates on invasive species in the wild are generally low.
Aims. We study the origin of tail-like structures recently detected around the disk of SU Aurigae and several FU Orionis-type stars. Methods. Dynamic protostellar disks featuring ejections of gaseous clumps and quiescent protoplanetary disks experiencing a close encounter with an intruder star were modeled using the numerical hydrodynamics code FEOSAD. Both the gas and dust dynamics were taken int
NGC 2419 is a peculiar Galactic globular cluster off set from the others in the size-luminosity diagram, and showing several chemical abundance anomalies. Here, we present Stromgren uvby photometry of the cluster. Using the gravity-and metallicity-sensitive c(1) and m(1) indices, we identify a sample of likely cluster members extending well beyond the formal tidal radius. The estimated contaminati
The central issue discussed in this thesis is the “essayistic mode”, which is usually described as a set of themes and characterization of the traditional written essay. In our more digitalized world today, it has been argued that some of these essayistic traits could be identified in other types of media, for example in essay films. Since the beginning of the 1990th century the capacity of essay
Problem: There are strong forces from for instance politicians, who want to allow third party access to the district heating market, as has already been done in the electricity and gas markets. But what would be the consequences of a third party access to the district heating market? Will it create a competitive market, and will it be able to put any pressure on the prices? What will be the conseq
The purpose of the research was to enrich the understanding of the process of corporatization of higher education and to demonstrate the importance of studying identity work. We conducted an inductive case study research basing our methods and methodology on hermeneutics and an interpretive paradigm. We developed our argumentation on the basis of interpretive and critical theory regarding identity
During the 1950’s and 1960’s an unexplainable phenomenon arose amongst middle class women in North America. Women in the suburbs experienced a feeling of emptiness even though they believed they had everything they could ever ask for in life. This phenomenon is covered by Betty Friedan in The Feminine Mystique (1963) where she discusses the identity crisis and loss of self that many women experien
Allteftersom företag har börjat att ompröva sättet de designar, tillverkar och avyttrar produkter inom ramarna för hållbar utveckling så har tillverkare av akustiska produkter varit långsamma ur startblocken. Majoriteten av akustiska produkter är fortfarande primärt sammansatta av nyråvara från petrokemiska resurser, vilka har en signifikant påverkan på miljön. Det är problematiskt ur både en miljAs industries have begun to rethink the way they design, make and dispose of products for the purpose of sustainable development, manufacturers of acoustic products have been slow off the mark. The majority of acoustic products are still made of primarily virgin material made from petrochemical resources, which have a significant impact on the environment. This is problematic from an environmental
