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Inference of antibody gene repertoires using transcriptome data has emerged as an alternative approach to the complex process of sequencing of adaptive immune receptor germline gene loci. The diversity introduced during rearrangement of immunoglobulin heavy chain variable (IGHV), diversity, and joining genes has however been identified as potentially affecting inference specificity. In this study,
Objective: The risk of certain psychiatric disorders is elevated among immigrants. To date, no population studies on immigrant health have addressed eating disorders. We examined whether risk of eating disorders in first- and second-generation immigrants differs from native-born Danes and Swedes. Method: All individuals born 1984–2002 (Danish cohort) and 1989–1999 (Swedish cohort) and residing in
This paper explores the evolution of Swedish stabilization policies through six policy regimes between 1873 and 2019. We focus on discretionary policy decisions by estimating policy shocks using a SVAR model. Through these shocks, we explore how stabilization policies have evolved over time and how policymakers responded to key economic events such as financial crises and wars. Our results show thThis paper explores the evolution of Swedish stabilisation policies through six policy regimes between 1873 and 2019. We focus on discretionary policy decisions by estimating policy shocks using a SVAR model. Through these shocks, we explore how stabilisation policies have evolved over time and how policymakers responded to key economic events such as financial crises and wars. Our results show th
This overview of progress made in preventing post-traumatic osteoarthritis (PTOA) was delivered in a workshop at the Orthopaedics Research Society Annual Conference in 2019. As joint trauma is a major risk factor for OA, defining the molecular changes within the joint at the time of injury may enable the targeting of biological processes to prevent later disease. Animal models have been used to te
Background and Aims: Alcohol use disorder (AUD) is associated with increased risk of non-fatal suicide attempt. We aimed to measure the strength and mechanistic nature of the association between AUD and increased suicide attempt and determine any causal pathways and/or shared risk factors. Design: We used Cox proportional hazards models in population-level and co-relative analyses to evaluate the
For extremely large telescopes, there is strong need for thin deformable mirrors in the 3-4 m class. So far, feasibility of such mirrors has not been demonstrated. Extrapolation from existing techniques suggests that the mirrors could be highly expensive. We give a progress report on a study of an approach for construction of large deformable mirrors with a moderate cost. We have developed low-cos
Bladder denervation and bladder outlet obstruction are urological conditions that cause bladder growth. Transcriptomic surveys in outlet obstruction have identified differentially expressed genes, but similar studies following denervation have not been done. This was addressed using a rat model in which the pelvic ganglia were cryo-ablated followed by bladder microarray analyses. At 10 days follow
Warmer or cooler spring in northern high latitudes will, for the most part, directly impact gross primary productivity (GPP) of ecosystems, but also carry consequences for the upcoming seasonal GPP. Spatiotemporal patterns of these legacy effects are still largely unknown but important for improving our understanding of how plant phenology is associated with vegetation dynamics. In this study, imp
Solid materials doped with rare-earth ions are considered an attractive platform for quantum information applications. One of the main reasons for this is the exceptionally long optical and hyperfine coherence times of the 4fn states, due to the shielding provided by the outer lying 5s and 5p electrons. This enables a large number of quantum operations before the system loses its coherence. Anothe
Hypertrophic scars (HTS) and keloids are forms of aberrant cutaneous healing with excessive extracellular matrix (ECM) deposition. Current therapies still fall short and cause undesired effects. We aimed to thoroughly evaluate the ability of growth hormone releasing peptide 6 (GHRP6) to both prevent and reverse cutaneous fibrosis and to acquire the earliest proteome data supporting GHRP6's acute i
Rapidly developing technology and an increasing number of products containing electrical or electronic functions, has led to discarded electrical and electronic equipment (EEE) being one of the fastest growing waste streams. The European Union (EU) has enacted several iterations of the Waste Electrical and Electronic Equipment (WEEE) Directive to address this complex waste stream. However, recycli
Since the end of the cold war issues concerning civil preparedness at the municipal level has been slumbering in Sweden. During WWII and the cold war Sweden had an extensive civil preparedness at all political levels. With the absence of the threat of war the civil preparedness in Sweden faded away. Now in a state of awakening the municipalities are starting to heighten the level of civil prepared
När någon går bort försvinner inte det den avlidne efterlämnar sig automatiskt. Ett dödsbo bildas som omfattar den avlidnes tillgångar och skulder. Normalt sett kommer dödsboet att förvaltas av dödsbodelägarna, det vill säga de som på något sätt kommer ha del av det som ingår i dödsboet genom arv eller genom testamente. Det ska eventuellt göras en bodelning mellan efterlevande make och dödsboet. DWhen a person passes away, an estate takes form which includes all the deceased’s assets and liabilities. Normally the estate is being taken care of by the parties to the estate. The parties to the estate is everyone who has a rightful claim on the estate, either by heritage according to Swedish law or according to a will from the deceased. Sometimes a division of the joint property between the sp
Denna uppsats syftar till att dels redogöra för den nyklassiska skolan, samt utvecklingen av straffsystemet och kriminalpolitiken i Sverige fr.o.m. år 1965 t.o.m. år 2019, dels utreda vilket inflytande nyklassicismen har haft på utvecklingen av desamma. Undersökningen utgår från följande huvudfråge-ställning: är de senaste decenniernas straffrättsliga och kriminalpolitiska utveckling, med ny- och This essay aims to describe the neoclassical school, as well as the develop-ment of the criminal system and criminal policy in Sweden as from 1965 until 2019, and to also analyse if the neoclassical school has had any influ-ence on the development. The study is based on the following main issue: is the punitive development of the criminal system and criminal policy of the recent decades a result o
This thesis addresses the challenge of transforming car-oriented, mono-functional big-box landscapes into multi-functional, walkable local-centre. It assembles an integrated framework from recent research and translates it into a design approach to be tried in a case study. In contrast to the proposed multi-functional approach, a monocentric urban system concentrates functions and advantages in
Forests are vital ecosystems that support biodiversity, regulate climate, and provide economic and social value. Their resilience is strongly influenced by harvesting methods, with selective cutting and rotation forestry having noticeably different impacts on carbon dynamics. Understanding these effects requires accurate data on the number and location of felled trees. Although modern harvesters c
Mer än en miljon ton av använda textilier exporteras från den Europeiska unionen (EU) varje år, ofta till det globala syd. Använda textilier exporteras i intresse av cirkulär handel och förlängning av en produkts livslängd på en andrahandsmarknad. Dock är en betydande andel av de exporterade textilierna inte lämpliga för återanvändning. I dessa fall hamnar sådana textilier ofta i informella avfallMore than one million tonnes of used textiles are exported from the European Union (EU) every year, often to the Global South. Used textiles are exported for reuse in the interests of circularity and extending the lifetime of a product on a secondary market. Nonetheless, substantial portions of the exported textiles are not fit for reuse. In these instances, such textiles often end up in informal
Barn och unga som enlig LVU är placerade på särskilda ungdomshem befin-ner sig i en särskilt utsatt situation. Utöver de särskilda befogenheter som ut-tryckligen regleras i LVU och som inskränker barnens grundläggande rättig-heter, används i praktiken även åtgärden fasthållning. Denna åtgärd är inte reglerad i LVU som särskild befogenhet men används ofta i samband med eller i stället för avskiljniChildren and young people who, according to the Care of Young Persons (Special Provisions) Act (the Act), are placed in special residential homes are in a particularly vulnerable state. In addition to the special authorities express-ly regulated by law, which restrict the fundamental rights of children, the measure of physical restraint is also used in practice. This measure is not regulated in th
När ett anställningsförhållande har tagit slut är arbetstagaren fri att börja konkurrera med sin tidigare arbetsgivare. Denna frihet innefattar däribland rätten att värva tidigare kollegor, börja arbeta hos en konkurrent till arbetsgivaren, och ta med den kundbas som etablerats under anställningsförhållandet. En konkurrensklausul kan emellertid temporärt förbjuda arbetstagaren från att konkurrera When an employment contract has come to an end, an employee is free to start competing with his or her former employer. This freedom includes the right to recruit former colleagues, to join a competitor of their former employer, and to keep the client base established during their previous employment. However, a non-compete clause can temporarily prohibit an employee from competing with their form
Andrahandsuthyrning har under en längre tid funnits på bostadsmarknaden och varit en vanligt förekommande form av uthyrning. Utöver den klassiska andrahandsuthyrningen finns en annan form av uthyrning på bostadsmarknaden, uthyrning i form av blockuthyrning. Blockuthyrning som uthyrningsform har funnits på bostadsmarknaden under en tid men är trots detta en förhållandevis okänd företeelse för gemenSubletting has existed in the housing market for a long time and is a common form of rental. In addition to the common form of subletting, another form of rental is the blockrental agreement. This form of rental, has been used in the housing market for a while but is still relatively unknown to the general public. A blockrental agreement is an agreement involving at least three apartments under
