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With the rapid progress in the development of new clinical biomarkers there is an unmet need of fast and sensitive multiplex analysis methods for disease specific protein monitoring. Immunoaffinity extraction integrated with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) analysis offers a route to rapid and sensitive protein analysis and potentially multiplex biomarker an
Popular Abstract in Swedish Kol-kolinteraktioner utgör starka kemiska bindningar. Detta innebär att de är relativt svåra att både bryta och bilda. Föreliggande avhandling sammanfattar mekanistiska studier av två reaktioner, Stillereaktionen och Heckreaktionen, med hjälp av vilka kol-kolbindningar kan bildas. Ett vanligt förekommande sammanfattningsnamn för denna typ av reaktioner är korskopplingsrThe present thesis deals with various types of palladium(II) and platinum(II) complexes and their use in homogeneous catalysis. The focus has been devoted to mechanistic investigations concerning the Stille and Heck reactions and studies under both catalytic and stoichiometric conditions were conducted. As a stoichiometric probe for studying the transmetallation step in the Stille reaction the pl
Background/aim: The role of the microbiome has been widely discussed in the etiology of appendicitis. The primary aim was to evaluate the microbiome in the normal appendix and in appendicitis specifically divided into the three clinically and histopathologically defined grades of inflammation. Secondary aims were to examine whether there were any microbiome differences between proximal and distal
The primary goal of this workshop was to identify the most appropriate method to estimate the potential effect of reduction in sodium consumption on mortality. Difficulty controlling hypertension at the individual level has motivated international, federal, state, and local efforts to identify and implement population-wide strategies to better control this problem; reduction of sodium intake is on
Shortcomings of current techniques used for the intracerebral transplantation of ventral mesencephalic dopamine neurons include low graft survival, high variability, considerable implantation trauma and suboptimal graft integration. In order to overcome these limitations, we have adopted a microtransplantation approach which allows precise and reproducible implantation of ventral mesencephalon cel
Development of environmentally friendly and cost-efficient energy sources has been a challenge for modern society since long ago. Sunlight is an infinite and costless source of energy on Earth, so it would be an enormous advantage to efficiently harvest and transform it into electrical energy used in our everyday life. In nature the process, which converts light energy into chemical energy, is cal
Abstract. Title: Supply Chain Optimization – for Sourced Production. Authors: Patricia Möller and Andreas Paulsson. Tutors: Jan Eskil Hollen – Business Developer, Lilleborg as, Orkla, Everth Larsson – Department of Industrial Management and Logistics, Division of Engineering Logistics, Lund University, Carl-Henric Nilsson – Department of Economics and Business Administration, School of economics a
Biodiversity was during the 1990s perceived as 'green gold'. With the emergence of the biotechnology industry, biodiversity prospecting, or bioprospecting, was perceived to provide opportunities to gain benefits for several purposes. Benefits would attribute towards conservation, development of source countries, new medicines, profits for the industry and welfare to local providers of biog
Lesion detection is a critical task for medical image understanding. While the problem has been widely addressed in a supervised semantic segmentation manner, the problem clinically appears more similar to novelty detection with few or no annotations for the lesion. The reason is two-fold: 1) it is intuitively easier to collect large dataset from healthy individuals than that from a specific type
The development and the use of anibiotics since the second half of XX century really affected the approach on treatment and prevention of infectious diseases. Despite a lot of resources and energies has been invested on the research, antibiotics resistance is a growing phenomenon in the last years. Today this problem has become a real public health priority worldwide, not only for the important cl
The claims for the potential of boreal and sub-boreal forests to combat negative effects of climate change have been substantial with over half of Earth’s primary forests found within boreal and temperate regions of the Northern Hemisphere. Given the likely occurrence of more extreme climate events in the future, ascertaining a better understanding of how climate effects, such as profound fluctu
Som ett led i att homogenisera den kinesiska befolkningen, har den kinesiska regeringen under längre tid bedrivit en kampanj för att avskaffa Xinjiang-provinsens inhemska folkgrupp Uigurer. Massiva konverteringsläger har inrättats där Uigurerna tvingas avsäga sig sin kultur, etnicitet och religion. Situationen beskrivs av journalister och politiker som ett kulturellt folkmord, men trots begreppetsSince 2017, the Chinese government has conducted an internment campaign against the Uighur Muslim minority in Xinjiang, China, with the goal of total assimilation into the majority population. Cultural genocide has emerged as a powerful rhetorical tool to describe the treatment of the Uighurs. Despite its conceptual relevance, it does not carry any legal authority as the current understanding of g
Various studies on clientelism usually start from a common puzzle: Why is campaign clientelism widely practised by politicians even when they have no means of ensuring reciprocity from the voters? Similarly, why is campaign clientelism widespread amongst voters despite its numerous negative consequences on societies, democracy, and development? These puzzles have motivated my research, where I att
This thesis addresses the Georgian paradox, a contradiction between liberal LGBTQ lawmaking and a public opinion with anti-LGBTQ attitudes. The paradox consists in the clash of globally formed formal rules and the more traditional informal institutions. The text focuses on credible explanations to the paradox. What establishes the paradox and which factors may contribute to the public opinion’s di
Med avstamp i den mänskliga rättigheten att söka asyl och den väletablerade rätten till internationellt skydd för den som uppfyller flyktingdefinitionen, belyser uppsatsen exklusionsbestämmelserna, undantaget som kan utesluta en person från flyktingskydd. De humanitära skyddsåtgärder som Flyktingkonventionen erbjuder förverkas nämligen om det finns synnerligen anledning att anta att den asylsökandThis thesis starts off in the human right to seek asylum and the recognized right to international protection for refugees. It examines the exclusion clauses, the exception that can exclude asylum claimants from refugee protection. The protective measures guaranteed by the Refugee Convention are forfeited if there are serious reasons for considering that the claimant has committed crime against pe
The addressees of EU competition rules are designated as undertakings. EU antitrust and merger rules apply only where an entity constitutes an undertaking. The notion of undertaking is not defined in the Treaties, rather it is developed in the case-law of the Court of Justice of the European Union and the decisional practice of the European Commission. An undertaking is defined as any entity engag
The aims of this study were to survey a sample of Swedish adults with self-reported ADHD and to investigate: 1) the extent of their reported impairments in social functioning and the relationship between these and the severity of their ADHD symptoms, comorbid symptoms of anxiety and depression, psychological flexibility and ADHD-specific quality of life (QoL); 2) investigate whether the participan
A sustainable development was defined by the Brundtlandscommission for the United Nations Conference on Environment and Development as "... a development that meets present needs without compromising future generations to meet their own needs". The definition includes a broad consideration of economic, environmental and social aspects. The definition thus creates a good example of the
Prosolviadomen innebar det största skadeståndet någonsin utdömt i Sverige. Det tar upp frågan om revisorns skadeståndsansvar gentemot bolaget, men också frågan om prövningen av orsakssamband. Hovrätten tillämpade i målet en bevislättnad för den skadelidande efter ett prejudikat från Högsta domstolen som kom ut samma år, 2013. Revisorn som kontrollerande organ i aktiebolaget har som uppgift att tThe Prosolvia judgment came with the largest damages ever imposed in Sweden. It addresses the issue of accountant-liability towards the company, but also the issue of the assessment of causality. The Court of Appeal applied in the case, an evidence-relief to the injured after a precedent from the Supreme Court which came out the same year, 2013. The accountant as the controlling body in the compa
