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Background and objective: Human studies of arterio-venous (AV) differences in drug concentrations and the consequences for pharmacokinetic modelling and concentration-effect relationships are very limited. We therefore investigated the intravenous and intra-arterial concentrations of alcohol (ethanol) during the absorption, distribution and elimination stages of alcohol metabolism in healthy men.
Context. X-ray extragalactic surveys are ideal laboratories for the study of the evolution and clustering of active galactic nuclei (AGN). Usually, a combination of deep and wide surveys is necessary to create a complete picture of the population. Deep X-ray surveys provide the faint population at high redshift, while wide surveys provide the rare bright sources. Nevertheless, very wide area surve
Objectives Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA). To date only scarce head-To-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs). Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (
Importance: Comprehensive and timely monitoring of disease burden in all age groups, including children and adolescents, is essential for improving population health.Objective: To quantify and describe levels and trends of mortality and nonfatal health outcomes among children and adolescents from 1990 to 2015 to provide a framework for policy discussion.Evidence Review: Cause-specific mortality an
Background: Aftermarket logistics is important for a manufacturing company to maintain customer satisfaction in the long run. However, the supply chain set for aftermarket parts is equally crucial as the original equipment. Modification or optimization of the logistics systems for slow-moving aftermarket items is inevitable. Sandvik, an engineering company in the mining industry is now interested
Purpose: Recent developments in external radiotherapy and its utilization with artificial in- telligence (AI) enables advanced treatment plans for a range of different disease sites. By adapting to the anatomy of the day, target coverage can be ensured while sparing more healthy tissue. The purpose of this project was to study the feasibility and benefits of daily cone beam computed tomography (CB
Anesthesiology is the medical specialty dedicated to the relief of pain and care of the surgical patient before, during and after surgery. Most of the work in anesthesiology is routine patient care, but because patients are sick and surgical procedures may develop in unexpected ways, anesthesiology by its nature often involves medical crises. In recent years, two concepts have gained increasing i
Sammanfattning Människans rätt till självbestämmande är en grundläggande rättighet som i de allra flesta sammanhang i livet tillskrivs stor betydelse. Även inom hälso- och sjukvården betonas respekten för människans integritet och autonomi. När det gäller livets slutskede och människans rätt att styra över hur och när hon vill avsluta sitt liv får självbestämmanderätten emellertid vika till förmåSummary The human right to self-determination is a fundamental right, which in most situations in life is considered to be of high importance. This approach also applies in the department of medical care, in which the respect for the individual integrity and autonomy is emphasized. Regarding the final stages of life, the right to self-determination and the right to control how and when a person w
I juni 2022 röstades ett lagförslag igenom i riksdagen vilket resulterade i att det kostnadsbaserade avdraget för resor till och från arbetet (arbetsresor) ändrades om i grunden till att vara en färdmedelsneutral och avståndsbaserad skattereduktion. Innan de nya reglerna hann träda i kraft den 1 januari 2023 ändrade sig riksdagen och röstade i stället igenom ett förstärkt reseavdrag med höjda schaIn June 2022, a bill was passed through Riksdagen which led to the cost-based write off for traveling to and from your employment (work commute) being changed to accommodate non-specific travel methods and distance based tax deduction. Before the new bills had gone into effect starting from the 1st of january 2023, the Riksdag changed their mind and opted to pass a new bill that allowed for higher
Background There is currently no standardized process for long-term follow-up care. As a result, management of post-stroke care varies greatly, and the needs of stroke survivors are not fully addressed. The Post Stroke Checklist was developed by the Global Stroke Community Advisory Panel as a means of standardizing long-term stroke care. Since its development, the Post Stroke Checklist has gained
Mineralogical and geochemical studies of the non-marine Permian–Triassic (P–Tr) boundary across two stratigraphically wellconstrained sections (Commando Drift Dam and Wapadsberg, Eastern Cape Province) in the southern Karoo Basin, South Africa, have been undertaken to provide further input on the cause of this mass extinction event, and so has a sedimentological and geochemical evaluation of a thi
Lund is a rapidly growing city, and in a short time two new research facilities, ESS and MAX IV, will be completed. These facilities will deliver their excess heat to the district heating network of Lund which puts a high demand on the network. Kraftringen Energi AB, which owns and operates the network, are also in the process of replacing old pipes which motivates a through investigation of which
Popular Abstract in Swedish Avregleringen av elmarknaden uppmuntrar kraftbolag och oberoende kraftproducenter till att driva sina kraftverksanläggningar på ett marknadsorienterat sätt. För att behålla de ekonomiska marginalerna på plussidan så har de mest populära åtgärderna varit att förbättra elverkningsgraden genom ändringar i hårdvaran samt höja totalverkningsgraden genom till exempel samproduThe deregulation of the electricity market drives utilities and independent power producers to operate heat and power plants as profit centers. In order to keep the economic margins on the credit side, the preferred measures have been to improve the electrical efficiency through changes in the hardware and boost the overall efficiency through e.g. combined heat and power (CHP) generation. The bett
Background: Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In the case of interleukin-1 (IL-1) inhibition using its receptor antagonist (IL-1Ra), like chondrocytes, synoviocytes also express IL-1 receptors that influence intra-articular IL-1
Populärvetenskaplig sammanfattning:En studie publicerad av NASA:s Goddard Institute for Space Studies år 2019 visade att de genomsnittliga globala temperaturerna under de senaste fyra åren (2015-2018) var de högsta som någonsin registrerats i människans historia. Den nyheten passar väl in i de alarmerande prognoserna om global uppvärmning, och kräver snabba och radikala handlingar. Att studera “teInnovative design and materials are needed to satisfy the demand for efficient and scalable devices for electronic and opto-electronic applications, such as transistors, LEDs, and solar cells. Nanostructured III-V semiconductors are an appealing solution, combining the excellent functional properties of III-V materials with the flexibility typical of nanostructures, such as the nanowires (NWs) stu
The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related g
Background: The relationship between dyslipidemia, inflammation and CV organ damage in type 2 diabetes mellitus (T2DM) is complex. Insulin resistance and inflammatory cytokines interleukins (ILs) increase plasma triglycerides (TG). ILs also up-regulate expression of matrix-metalloproteinases (MMPs) that, together with TG, decrease high density lipoprotein cholesterol (HDL) levels. High TG, low HDL
The ice cover presence on the surface of a lake insulates the water body from the atmosphere. This prevents or reduces the influence of processes which depend on the exchange between the atmosphere and the water surface. This implies significant reduction or elimination of some processes taking place at the open water surface; for instance, a substantial reduction in solar energy penetrating to th
Introduction Compression neuropathies (CN) in the upper extremity, the most common being carpal tunnel syndrome (CTS) and ulnar nerve entrapment (UNE), are frequent among patients with diabetes mellitus (DM). Earlier studies have shown contradicting results regarding DM as a risk factor for CN. Thus, the aim of the present population-based, longitudinal study was to explore potential associations
Background/Purpose: The aim of this study was to estimate the incidence rate and prevalence of coronary artery diseases (CAD) in patients with temporal artery positive giant cell arteritis (TAB+GCA) from a defined population in southern Sweden, and to describe characteristics of CAD in this sample.Methods: The study cohort consisted of 1202 patients (71.9% women) diagnosed with TAB+GCA between 199
