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Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased risk of type 2 diabetes in samples from Iceland, Denmark, and the U.S. We genotyped 13 single nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based and case-control designs from Scandinavia, Poland, and the U.S. We convincingly confirmed the previous association of TCF7L2 SNP
Previous studies have suggested that depression increases the risk for diabetes and that this may be mediated through insulin resistance. The study aimed to analyze if self-rated symptoms of depression are related to insulin resistance among middle-aged and older Swedish women with features of the metabolic syndrome and being at risk for type 2 diabetes mellitus. We analyzed data from 1047 Swedish
A rapid (6.5 min) and simple one-step magnetic immunoassay (MIA) has been developed for analysis of human urinary albumin in near patient settings. Polyclonal rabbit anti-human albumin was used as a capture antibody and monoclonal mouse anti-human albumin as a detection antibody in a two-site immunometric assay requiring no additional washing procedures. The polyclonal anti-human albumin was conju
Differential gene expression analysis, using high-density microarray chips, demonstrated 300-400 genes to be deregulated in mantle cell lymphomas (MCLs) compared with normal B-cell populations. To investigate the significance of this genetic signature in lymphoma etiology and diagnostics, we selected 90 annotated genes involved in a number of cellular functions for further analysis. Our findings d
We study an extended bootstrap percolation process in several steps in dimension one, assuming noncyclic boundary conditions. We study the asymptotic behavior of the process as the size of the underlying graph goes to innity. We nd a phase transition with respect to the initial conditions. The phase diagram on the set of initial conditionals of the extended process is described completely. This pr
The ultrafast photophysics of [Ru(bpy)(2)dppz](2+) (dppz = dipyrido[3,2-a:2',3'-c]-phenazine) embedded into the walls of phospholipid vesicles has been studied by femtosecond time-resolved pump-probe spectroscopy. While [Ru(bpy)(2)dppz](2+) has been studied intensively with respect to its intramolecular charge transfer processes, which are associated with the well known light-switch effect, this s
Ditrysia comprise close to 99 % of all butterflies and moths. The evolutionary relationships among the ditrysian superfamilies have received considerable attention in phylogenetic studies based on DNA and transcriptomic data, but the deepest divergences remain for large parts unresolved or contradictory. To obtain complementary insight into the evolutionary history of the clade, and to test previo
A search for new interactions and resonances produced in LHC proton-proton (pp) collisions at a centre-of-mass energy root s = 7 TeV was performed with the ATLAS detector. Using a dataset with an integrated luminosity of 36 pb(-1), dijet mass and angular distributions were measured up to dijet masses of similar to 3.5 TeV and were found to be in good agreement with Standard Model predictions. This
BACKGROUND. Recently, the gene for cysteine-rich secretory protein 3 (CRISP-3) was reported to be highly upregulated in prostate cancer (PCa) compared to benign prostatic tissue. The current aims were to investigate diagnostic use of tissue expression and immunodetection in serum of CRISP-3 for detection or monitoring of PCa. METHODS. Radical prostatectomy specimens and tissue microarrays from tra
[3H]Leucine- and [35S]sulfate-labeled proteoheparan sulfates were isolated from postconfluent or proliferating cultures of human skin fibroblasts. Cell layers were solubilized by Triton X-100, and transferrin-binding macromolecules were isolated by affinity chromatography. Proteoglycans with no affinity for transferrin were purified by using ion-exchange and gel permeation chromatography. Postconf
Objective: To evaluate efficacy and cost-effectiveness of budesonide/formoterol (Symbicort*) maintenance (one dose once or twice daily) plus additional doses as needed (Symbicort Maintenance And Reliever Therapy, SMART) compared with a higher fixed dose of budesonide/ formoterol with formoterol as needed in patients with persistent asthma. Study design and methods: 6-month, open, randomised study
The purpose of this study was to evaluate the effect of pelvic floor muscle training in women with urinary incontinence after ischmic stroke measured by quality of life parameters. Three hundred thirty nine medical records of stroke patients were searched. Twenty-six subjects were randomized to a treatment group or a control group in a single-blinded,randomized study design. The intervention inclu
Objective To investigate the role of rheumatoid factor (RF) status and anti-citrullinated peptide antibody (ACPA) status as predictors of abatacept (ABA) effectiveness in patients with rheumatoid arthritis (RA). Methods We conducted a pooled analysis of data from 9 observational RA registries in Europe (ARTIS [Sweden], ATTRA [Czech Republic], BIOBADASER [Spain], DANBIO [Denmark], GISEA [Italy], NO
Objectives To describe the incidence of atrioventricular (AV) block II-III, atrial fibrillation (AF), pacemaker implantation (PM) and aortic regurgitation in patients with ankylosing spondylitis (AS), undifferentiated spondyloarthritis (uSpA) and psoriatic arthritis (PsA) compared with the general population (GP) and with each other. Methods A prospective nationwide study with cohorts of patients
In a Swedish sample of persons eligible for disability services and aged 55 years or older in 2012, persons (n = 601) with autism spectrum disorder diagnoses registered in specialist care were identified. Register data concerning diagnoses of other psychiatric disorders, psychiatric care, and psychiatric medication were reviewed. More than 60% had been in contact with psychiatric care. The majorit
This research paper analyses and assesses the impacts of the Israeli imposed physical obstructions on the mobility of the Palestinians in the West Bank, using a case study focused on the Bethlehem – Ramallah route. Arguably, the prevailing Israeli imposed physical obstructions, or mobility restrictions, in the West Bank territory have negative implications on the articulation of sustainable Palest
Sverige har länge varit ett föregångsland i arbetet att bekämpa våld mot barn. Trots detta utsätts fortfarande många barn för våld och mörkertalet bedöms vara stort. Stiftelsen Allmänna Barnhusets senaste nationella kartläggning av våld mot barn visade att psykiskt våld och försummelse är de vanligaste formerna av våld som föräldrar använder mot sina barn. I oktober 2021 gav Regeringskansliet en sSweden has long been a pioneering country in combating violence against children. Despite this, many children are still exposed to violence and the number of unreported cases is estimated to be high. Stiftelsen Allmänna Barn-huset's latest national survey of violence against children showed that psychological violence and neglect are the most common forms of violence that parents use against t
Higher education for refugees is garnering greater attention worldwide as a means of countering the negative effects of displacement, particularly in response to the Syria crisis. This thesis contributes to literature seeking to understand the psychosocial outcomes of higher education for refugees. Through the theoretical lens of subjective well-being, which prioritises individuals’ perceptions of
Fastighetsköp utgörs oftast av stora ekonomiska värden. Därmed åläggs säljaren och köparen åtaganden för att tillgodose sina egna intressen. Syftet med uppsatsen har varit att undersöka upplysningspliktens omfattning vid fel i fastigheten, specifikt då upplysningsplikten inte uttryckts i jordabalken. Vägledning har därmed behövt hämtas från förarbeten och praxis. Praxis har återgetts för att illusReal estate transactions often have a high economic value; therefore, the seller and the buyer typically impose conditions on the sale to ensure that their interest are protected. This thesis purpose is to explore the extent of the seller’s disclosure regarding defects in the property for sale, particularly when the seller’s disclosure is not mandated by the Swedish Land Code. Guidance regarding t
