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https://www.humanrights.lu.se/nina-gren - 2026-07-22

Background No effective standard treatment exists for patients with radioiodine-refractory, advanced differentiated thyroid carcinoma. We aimed to assess efficacy and safety of vandetanib, a tyrosine kinase inhibitor of RET, VEGFR and EGFR signalling, in this setting. Methods In this randomised, double-blind, phase 2 trial, we enrolled adults (aged >= 18 years) with locally advanced or metastatic

Improving energy efficiency in buildings is an important part of the EU’s ambitions to address climate change and other environmental, social and economic challenges. This is a role that is traditionally taken on by varying levels of governments, each level addressing elements that fall within their areas of jurisdiction. In today’s increasingly decentralised and yet simultaneously complex, integr

Background: Knowledge is increasing about TSC-Associated Neuropsychiatric Disorders (TAND), but little is known about the potentially confounding effects of intellectual ability (IA) on the rates of TAND across age, sex, and genotype. We evaluated TAND in (a) children vs. adults, (b) males vs. females, and (c) TSC1 vs. TSC2 mutations, after stratification for levels of IA, in a large, internationa

Populärvetenskaplig sammanfattning: En verksamhet eller åtgärd kan ha stor inverkan på människor, djur, växter, mark, vatten, luft, klimat, landskap och kulturmiljö. För att fatta bästa möjliga beslut om en projekt-ut-formning som tar hänsyn till konsekvenserna för olika berörda miljövärden åter-finns kravet på miljökonsekvensbeskrivning, MKB, i svensk lagstiftning. Syftet med en MKB är att identiAn activity or a measure might have a great impact on people, animals, plants, soil, water, air, climate and landscape. In order to describe the direct and indirect effects an intended activity might have an Environmental Impact Assessment (EIA) must be carried out. This demand is regulated in Swedish legislation and makes it possible to achieve as small impact on the environment as practicable. A

The overall aims of this thesis were to investigate the prevalence, severity and bother of Lower Urinary Tract Symptoms (LUTS) in a clinical sample of stroke patients and to evaluate the effect of pelvic floor muscle training (PFMT) in women with urinary incontinence after ischemic stroke. The thesis consisted of 6 articles based on 4 studies and a review. In the first study (Paper I), the Danish

Today, driver support tools intended to increase traffic safety, provide the driver with convenient information and guidance, or save time are becoming more common. However, few systems have the primary aim of reducing the environmental effects of driving. The aim of this project was to estimate the potential for reducing fuel consumption and thus the emission of CO, through a navigation system wh

In a prospective study of a consecutive breast cancer series accumulated in the period 1978-82, the S-phase fraction (SPF) and ploidy status were determined by flow cytometry performed on cell nuclei derived from samples of 580 primary tumors. Sixty percent of the tumors were non-diploid. After correction for debris the median SPF values were 7.3% overall, 12% for non-diploid tumors, and 2.9% for

Popular Abstract in Swedish Under det senaste decenniet har risker med och alternativ till allogent blod (blod från främmande givare) debatterats mycket pga. risken för smitta, allergiska reaktioner, samt starka indicier som talar för att blod från främmande givare kan påverka immunförsvaret hos mottagaren. Därför vill man gärna begränsa mängden tillfört givarblod under kirurgiska ingrepp på barn,In children, it is often desirable to minimize allogenic blood transfusion, and this thesis explores the physiology of an alternative method of managing perioperative blood loss: hemodilution with Ringer´s dextran. Methods Clinical studies: Arterial pressure, superior caval venous oxygen saturation (ScvO2) and blood lactate concentration (L) were studied during bone marrow harvesting (BMH) on 23

Aims/hypothesis Genetic and epidemiological studies suggest an association between gestational diabetes mellitus and type 2 diabetes. Both are polygenic multifactorial disorders characterised by beta cell dysfunction and insulin resistance. Our aim was to investigate whether common genetic variants that have previously been associated with type 2 diabetes or related phenotypes would also confer ri

OBJECTIVES: To evaluate the efficacy, safety, and tolerability of a new, once-daily extended-release (ER) formulation of tolterodine in treating overactive bladder in older (greater than or equal to65) and younger (<65) patients. DESIGN: A 12-week double-blind, placebo-controlled clinical trial. SETTING: An international study conducted at 167 medical centers. PARTICIPANTS: One thousand fifteen pa

The aim of this thesis was to reconstruct the glaciodynamics, deglacial landforms, isostatic uplift and to date the deglaciation. Glaciodynamics and deglacial landforms were focused on to provide a process and depositional model for De Geer moraine and Niemisel moraine and to reveal their internal and spatial relationship, based on detailed sedimentological and structural investigations. The isost

Background. To evaluate the relationship between age and poor ovarian response to pregnancy and cancellation rate after IVF stimulation. Methods. Poor ovarian response was defined as <= 5 follicles at ovum pick up (OPU). Out of 1,706 consecutive OPUs performed during 2003/2004, 290 poor responders were identified. This cohort of poor responders was divided into two groups, 'older' and 'younger', w

This 8-year controlled, follow-up study in 66 Swedish soccer women evaluated the effect of training and reduced training on BMD. The players who retired during the follow-up lost BMD in the femoral neck, whereas the controls did not. Introduction: Physical activity during adolescence increases BMD, but whether the benefits are retained with reduced activity is controversial. Materials and Method

This thesis discusses modeling and implementation of reconfigurable hardware architectures for real-time applications. The target application in this work is digital holographic imaging, where visible images are to be reconstructed based on holographic recordings. The reconstruction process is computationally demanding and requires hardware acceleration to achieve real-time performance. Thus, this

Background: The aim of this study was to examine in elderly men a relationship between depressive symptoms, peripheral vascular disease and cerebral blood flow (CBF). Methods: Population-based cohort study started with an examination of 809 men at age 55, followed by the first (age 68ys) and second follow up (age 82ys). 128 survivors were examined at age 82 with Tc-99m-HMPAO-SPECT to estimate CBF,

Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female)

Intermittent Parathyroid Hormone (PTH)((1-34)) has an established place in osteoporosis treatment, but also shows promising results in models of bone repair. Previous studies have been dominated by closed fracture models, where union is certain. One of the major clinical needs for anabolic therapies is the treatment of open and high energy fractures at risk of non-union. In the present study we th

Background: Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and adverse outcome in several cancer types. We recently demonstrated that overexpression of PODXL is an independent factor of poor prognosis in colorectal cancer (CRC). The aim of this study was to validate these results in two additional indepen