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Background: Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and adverse outcome in several cancer types. We recently demonstrated that overexpression of PODXL is an independent factor of poor prognosis in colorectal cancer (CRC). The aim of this study was to validate these results in two additional indepen
Hydroquinone glycosides were produced by transglycosylation reactions catalyzed by cyclodextrin glucanotransferase (CGTase) from Thermoanaerobacter sp. (Toruzyme (R) 3.0L). The reactions were carried out in an aqueous system containing hydroquinone (HQ) and maltodextrin as acceptor and donor substrate molecules respectively. The conditions for the synthesis of hydroquinone glucoside (alpha-arbutin
Background: Screening for bacterial colonization and antimicrobial resistance (AMR) among a defined population could aid in the identification of at-risk populations and provide targets for antibiotic stewardship and infection control programmes. Methods: Two hundred and sixty-eight participants at 11 Swedish nursing homes underwent serial screening for colonization with Escherichia coli between M
In this study, we partly characterize major histocompatibility complex (MHC) class II B in the blue tit (Cyanistes caeruleus). A total of 22 individuals from three different European locations: Spain, The Netherlands, and Sweden were screened for MHC allelic diversity. The MHC genes were investigated using both PCR-based methods and unamplified genomic DNA with restriction fragment length polymorp
A candidate for chiral bands was found in Tl-198 for the first time in a mass region of oblate (or nonaxial with gamma >= 30 degrees) deformed nuclei. Two bands show very similar quasiparticle alignments, moments of inertia, and B(M1)/B(E2) ratios. They have a relative excitation energy of about 500 keV and different patterns of energy staggering. Calculations using the two-quasiparticle-plus-tria
This report deals with the implementation of a Japanese word prediction engine written by the author. As this type of software does not seem to exist for Japanese at the time of writing, it could prove useful in Japanese augmentative and alternative communication (AAC) as a software tool used to improve typing speed and reduce the amount of keystrokes needed to produce text. Word prediction, in co
Commercial sexual exploitation of Children and Adolescents (CSEC) is an increasing problem all over the world and especially in developing countries with growing tourist industries. In these countries CSEC and Child Sex Tourism have become two often closely connected problems. In Costa Rica there are many NGOs and governmental institutions working with these problems through prevention, attention
I denna uppsats utreds och analyseras hur rättsväsendet hanterar hatbrott begångna på internet. År 2013 rapporterade Brottsförebyggande rådet att personuppklarningen vad gäller hatbrott begångna på internet är mycket låg. Följaktligen fortsätter uppsatsen med att identifiera orsakerna till den låga personuppklarningen samt de brister rättsväsendet besitter på området. I avslutande del av uppsatsenThis paper is set out to investigate and analyze how the judicial system handles hate crime committed on the internet. In 2013 the Swedish national council of crime prevention (Brå) reported that the clearance rate in terms of hate crime committed on the internet is very low. Hence the paper continues with identifying the causes of the low clearance rate and the shortcomings the judicial system po
Den 1 juli 2018 trädde en ny våldtäktslagstiftning i kraft som tar utgångspunkt i avsaknaden av ett frivilligt deltagande, till skillnad från hittillsvarande reg-lering som har utgått från förekomsten av våld, hot eller otillbörliga utnyttjanden. Vidare infördes även ett nytt brott med rubriceringen oaktsam våldtäkt, vilket är föreskrivet i 6 kapitlet 1 a § BrB. Brottet oaktsam våldtäkt tar sikte On July 1, 2018, a new legislation regarding rape took effect, which is based on the lack of voluntary participation, unlike the previous regulations which required violence, threats or undue exploitation. Furthermore, a new offence was passed with the classification negligent rape, prescribed in Chapter 6, 1 a § of the Penal Code. The crime of negligent rape includes the same criminal act – sexua
Objective: The heterogeneity of systemic lupus erythematosus (SLE) constitutes clinical and therapeutical challenges. We therefore studied whether unrecognized disease subgroups can be identified by using autoantibody profiling together with HLA-DRB1 alleles and immunological and clinical data. Methods: An unsupervised cluster analysis was performed based on detection of 13 SLE-associated autoanti
BACKGROUND: Neuropsychiatric (NP) involvement and fatigue are major problems in systemic lupus erythematosus (SLE). S100A8/A9 is a marker of inflammation and responds to therapy in SLE patients. S100A8/A9 has an immunopathogenic role in various neurological diseases. We investigated S100A8/A9 in relation to NP-involvement and fatigue in SLE.METHODS: 72 consecutive SLE outpatients at a tertiary cen
In order to fully understand the underlying processes of catalysis, it is vital to combine measurements of the catalyst surface, where the reaction occurs, with measurements of the gas concentration close to the catalyst. We have developed a convenient setup, which uses a single laser system to visualise the gas surrounding a working catalyst in situ at realistic operating conditions. Planar Lase
Den som är yngre än 18 år stadgas vara omyndig enligt gällande rätt, men den som är 15 år gammal kan bli föremål för straffrättsliga påföljder om den begått ett brott. Enligt gällande rätt bör dock straffrättsliga påföljder dömas ut mycket restriktivt när lagöverträdare är mellan 15 och 17 år, eftersom vårdande åtgärder angetts erhålla företräde. Enligt barnkonventionen, vilken gäller som svensk lAccording to the Swedish Parental Code (1949:381), chapter 9, section 1, a person below the age of eighteen years is considered a minor. But according to the Swedish Penal Code (1962:700), chapter 1, section 6, a person above the age of fifteen may be subject to sanctions if he or she has committed a crime. According to the Convention on the Rights of the Child, which was incorporated as Swedish l
Den första januari 2020 trädde barnkonventionen i kraft som svensk lag. Två av konventionens grundläggande principer är barnets bästa och barnets rätt att komma till tals. Principerna är aktuella vid alla frågor som rör barn, exempelvis vid beslut i vårdnadstvister. Ett syfte med denna uppsats är att undersöka om Sverige uppfyller sina åtaganden enligt barnkonventionen vid vårdnadsrelaterade tviOn the first of January 2020 the United Nations Convention on the Rights of the Child (CRC) came into force as Swedish law. The best interest of the child, in Article 3, and the child’s right to be heard, in Article 12, are two fundamental principles of the CRC. The principles are relevant in all questions concerning children, with one important aspect being custody disputes. One of the aims of t
This study explores the receivers’ experience and interaction with nation branding and how this affects their image formation since most of the research within the field analyzes nation branding from the sender’s point of view. A qualitative case study has been executed with an interpretative approach from a sensemaking perspective on the nation branding campaign “The Swedish Number”. The Swedish
We report complete mitochondrial (mt) genomes for a penguin (little blue, Eudyptula minor) and a goose (greater white-fronted, Anser albifrons). A revised annotation of avian and reptile mt genomes has been carried out, which improves consistency of labeling gene start and stop positions. In conjunction with this, a summary of mt gene features is presented and a number of conserved pattems and int
Recent advances in magnetic resonance imaging have made it possible to visualize and quantify flow of cerebrospinal fluid (CSF) in the brain. The net flow of CSF through the cerebral aqueduct was used to measure CSF production in six normal volunteers at different times during a 24-h period. CSF production varied greatly both intra- and interindividually. The average CSF production in each time in
Förevarande uppsats behandlar vårdnadsregleringen i 6 kap. föräldrabalken (1949:381) och huvudsakligen principen om barnets bästa. Den finns i 6 kap. 2 a § FB som stadgar att barnets bästa skall vara avgörande för alla beslut om vårdnad. Att objektivt fastställa vad som är barnets bästa är idag inte möjligt. Vissa riktlinjer för domstolens bedömning finns i lag och förarbeten. Men lagstiftaren har
Populärvetenskaplig sammanfattning Kartering av makrofyter, framtagandet av en klassificeringsmetod för att kunna beräkna ekologisk status för Ålands skärgård och skapandet av miljöövervakningsprogram Europeiska unionen har i sitt miljöarbete bestämt att varje medlemsland ska upprätta övervakningsprogram och klassificeringsmetoder för att övervaka miljöns ekologiska status. Varje medlemsland anAbstract This mater project was conducted in Åland by assignment by the Government of Åland Islands. The project consisted of two parts, one survey of macrophytes and classification of the ecological status and a proposal on a marine monitoring program. The survey of macrophytes was conducted in the late summer of 2012, by SCUBA divers along 50 meters long transect at twelve sites in the Åland ar
