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Background : Currently, antiretroviral therapy (ART) is recommended for all HIV-positive patients with tuberculosis (TB). The timing of ART during the course of anti-TB treatment is based on CD4 cell counts. Access to CD4 cell testing is not universally available; this constitutes an obstacle for the provision of ART in low-income countries. Objective : To determine clinical variables associated w
A search is presented for the direct pair production of a chargino and a neutralino [Formula: see text], where the chargino decays to the lightest neutralino and the [Formula: see text] boson, [Formula: see text], while the neutralino decays to the lightest neutralino and the 125 GeV Higgs boson, [Formula: see text]. The final states considered for the search have large missing transverse momentum
Popular Abstract in Swedish Cystisk Fibros Cystisk Fibros (CF) är en relativt vanlig ärftlig sjukdom. Ungefär 1/37 personer i Sverige bär på anlag till CF, men bärare har inga symptom och vet därför inte att de har anlagen. För att få sjukdomen måste fostret få två anlag, ett från vardera föräldern, vilket är 25% risk vid varje graviditet för föräldrapar där båda är bärare. CF är en dödlig sjukdomCystic Fibrosis (CF) is a severe hereditary disorder leading to progressive deterioration of lung function and death. This thesis describes the demography of CF in Sweden, its treatment, with special reference to physiotherapy, and its effects on lung function and peak working capacity (PWC). The study is based on Swedish CF patients and evaluates our current CF treatment package, which differs fr
IgE is responsible for type 1 mediated allergic reactions, affecting an increased part of the European population. Even though a large part of the population is affected, further being an economical burden for society, little is known about the human IgE repertoire. Variation in antibodies are mainly found in antibody variable domains, and gained understanding of the IgE repertoire can be obtained
The issue of thin capitalization has risen in importance in recent years, to the point that it warranted international action. That action came in the form of Action 4 of the OECD BEPS Project, of Article 4 of the EU ATAD and of the new interest deduction limitation rules in the national Swedish legislation. The main part of the chosen rule in all these instances disallows interest deduction over
Against the backdrop of universality proposals claiming that all the world’s languages share the way they conceptualise and express THINKING, this study investigates verbs of thinking in German and Swedish in a comparative perspective. In particular, it examines semantic specificity in verbs of thinking (the restricted availability of only one specific verb in a certain context), and the potential
In today’s connected world, businesses are increasingly going online. Additionally, the online industry is transforming into an international business arena, flourishing with opportunities to grow and expand. However, the internationalisation has raised a number of challenging issues. One of these challenges is foreign exchange. Foreign exchange is needed to sell and buy on markets with different
A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses tip to 2400 mg/day. The study comprised a run-in period of two weeks, two treatment periods of five weeks separated by a three weeks' washout period.
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Graviditetsdiabetes (GDM) definieras som ett diabetestillstånd som upptäcks under graviditet. Ofta orsakas detta tillstånd av de hormonförändringar som uppträder under graviditet vilka medför en ökad insulinresistens, dvs. ett ökat motstånd mot insulinets effekter. Diagnosen GDM utesluter dock inte diabetes av annan orsak soThe aims of this work were to determine the prevalence of postpartum diabetes among women with gestational diabetes mellitus (GDM) in a prospective study 5 years postpartum; to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify possible markers and predictors for the development of manifest diabetes. The subjects were recruited
Background and purpose: There is an urgent need to improve patient-selection to surgical treatment in advanced ovarian cancer as our results showed that cytoreductive surgery was without effect or even detrimental in a yet unknown subgroup of women. With an ageing population, 30% of women with advanced ovarian cancer in Sweden are >75 years. Nevertheless, there are no recommendations on patient-se
Background: The existence of a “minority tax,” defined as the burden of extra responsibilities placed on minorities relative to non-minorities of the same position, has been documented across various fields, including and beyond medicine. This study sought to quantify the types and extent of the minority tax faced by minority orthopaedic surgeons, as well as evaluate the degree to which this work
PURPOSE: The partial volume effect (PVE) is an important source of bias in brain perfusion measurements. The impact of tissue PVEs in perfusion measurements with dynamic susceptibility contrast MRI (DSC-MRI) has not yet been well established. The purpose of this study was to suggest a partial volume correction (PVC) approach for DSC-MRI and to study how PVC affects DSC-MRI perfusion results.METHOD
The research presented in this thesis is focused on characterization of photophysical properties of lowest singlet excited states of carotenoids and their functions in the process of photosynthetic light harvesting. It is shown that the various light-harvesting complexes utilize different strategies to achieve efficient energy transfer from carotenoids to (bacterio)chlorophylls. Any study of energ
Objective. The aim of the study was to survey existing research about fatigue among older people with chronic non-malignant pain. Method. A structured literature review was carried out using the Medline database. The terms ‘fatigue’ and ‘tiredness’ were used synonymously. These subject headings were combined with pain. A literature search was made in 2004 and included articles back to 1995. Resu
Popular Abstract in Swedish Syftet med undersökningen är att beskriva de livsförändringsprocesser som blir nödvändiga då en person drabbas av kronisk sjukdom eller ett funktionshinder. Vad innebär det att drabbas av en kronisk sjukdom eller ett funktionshinder? Hur lär man sig leva med de nya livsvillkoren? Dessa frågor belyses utifrån intervjuer med kvinnor som drabbats av kronisk smärta (fibromThe aim of this thesis is to study the life-changing processes necessary when a person is faced with the demands caused by chronic illness or disability. As subjects for the study, women with chronic pain (fibromyalgi and myofascial pain syndrome), were chosen. Eighteen women active in working life were interviewed on two occasions, with an interval of two months. The women have been living with t
In recombinant, xylose-fermenting Saccharomyces cerevisiae, about 30% of the consumed xylose is converted to xylitol. Xylitol production results from a cofactor imbalance, since xylose reductase uses both NADPH and NADH, while xylitol dehydrogenase uses only NAD(+). In this study we increased the ethanol yield and decreased the xylitol yield by lowering the flux through the NADPH-producing pentose
Objective To compare the time taken to establish a clinical diagnosis of Frontotemporal dementia (FTD) relative to a diagnosis of early onset Alzheimer's dementia (AD). Methods The data came from 89 patients under the age of 65 years, 52 of whom met the Manchester-Lund criteria for Frontotemporal dementia; 20 of these came from Lund University Hospital in Sweden. The other 32 patients with FTD alo
To describe the Avodart after Radical Therapy for prostate cancer Study (ARTS), investigating the use of dutasteride (a dual 5 alpha-reductase inhibitor that suppresses intraprostatic dihydrotestosterone, reduces tumour volume and improves other markers of tumour regression in prostate cancer) to prevent or delay disease progression in patients with biochemical recurrence after therapy with curati
