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The role of cholesterol differs in the two compartments of the testis. In the interstitial tissue, cholesterol is necessary for the synthesis of testosterone, whereas in the seminiferous tubules, membrane cholesterol content in developing germ cells will influence the gametes' fertility. Here we evaluate the hormone-sensitive lipase (HSL) modulation of the cholesterol metabolism in each compartmen

Genom att utveckla nya lasrar och fotonkällor samt skräddarsydda lösningar för tillämpad spektroskopi i olika miljöer, adresserar profilområdet samhällsutmaningar relaterade till klimatförändringar, miljöpåverkan och bekämpning av cancer och andra hot mot människors hälsa.By developing novel lasers and photon sources as well as tailored solutions suited for applied spectroscopy in different environments, the profile area addresses specific societal challenges related to climate change, environmental impact and combatting cancer and other threats to human health.

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. One of the hallmarks of the disease is a multitude of autoantibodies, indicating a breakdown in self tolerance. The corresponding antigens have been fou

Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.

Radiocarbon analysis of the carbonaceous aerosol allows an apportionment of fossil and non-fossil sources of airborne particulate matter (PM). A chemical separation of total carbon (TC) into its subfractions organic carbon (OC) and elemental carbon (EC) refines this powerful technique, as OC and EC originate from different sources and undergo different processes in the atmosphere. Although C-14 an

Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen fibrils in vitro. We have examined whether such mAbs have detrimental effects on pre-existing cartilage. Bovine cartilage explants were cultured over 21 days in the presence of two arthritogenic mAbs to

Background: Malaria kills almost 1 million people every year, but the mechanisms behind protective immunity against the disease are still largely unknown. Methodology/Principal Findings: In this study, surface plasmon resonance technology was used to evaluate the affinity (measured as kd) of naturally acquired antibodies to the Plasmodium falciparum antigens MSP2 and AMA1. Antibodies in serum samp

Fokus för forskningen kan sammanfattas med orden vardag, hälsa och välbefinnande. Aktivitet, dess komplexitet, mening och vilken betydelse det har för människors upplevelse av hälsa och välbefinnande – är centralt. Vi som är organiserade i gruppen arbetar i varierande omfattning med undervisning, forskning och med att sprida våra resultat till brukare och olika verksamheter i samhället.The research in the Occupational therapy and occupational science-group is focused on occupation, health and wellbeing. The complexity, meaning and importance of the concept of everyday occupations for people’s health, is the key. The group works to a varying extent at teaching, research and dissemination of our results to users, in the society.

BACKGROUND: Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome p

Handkirurgi och dess specifika omvårdnad U PP D R A G SU TB IL D N IN G Institutionen för hälsovetenskaper erbjuder utbildningar som genomförs av lärare vid Lunds universitet och i många fall i samarbete med arbetslivet - en garanti för både ämnesmässig bredd och aktualitet, ett vetenskapligt djup och en modern pedagogik. Institutionens uppdragsverksamhet sker i samarbete med Lund University Commi

https://www.medicin.lu.se/sites/medicin.lu.se/files/handkirurgi_och_dess_specifika_omvayrdnad.pdf - 2026-05-31