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Genome editing has proven to be highly potent in the generation of functional gene knockouts in dividing cells. In the CNS however, efficient technologies to repair sequences are yet to materialize. Reprogramming on the mRNA level is an attractive alternative as it provides means to perform in situ editing of coding sequences without nuclease dependency. Furthermore, de novo sequences can be inser
Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associations of rare variants (with minor allele frequencies of less than 0.5%) in 4 genes at exome-wide si
Water exchange of square-planar Pd(H2O)42+ has been studied as a function of temperature (240 to 345 K) and pressure (0.1 to 260 MPa, at 324 K) by measuring the 17/O-FT-NMR line-widths of the resonance from coordinated water at 27.11 and 48.78 MHz. The following exchange parameters were obtained: k298ex = (560 ± 40) s−1, ΔH* = (49.5 ± 1.9) kJ mol−1, ΔS* = – (26 ± 6) J K−1 mol−1 and ΔV* = – (2.2 ± Water exchange of square-planar Pd(H2O)42+ has been studied as a function of temperature (240 to 345 K) and pressure (0.1 to 260 MPa, at 324 K) by measuring the 17/O-FT-NMR line-widths of the resonance from coordinated water at 27.11 and 48.78 MHz. The following exchange parameters were obtained: k298ex = (560 ± 40) s−1, ΔH* = (49.5 ± 1.9) kJ mol−1, ΔS* = – (26 ± 6) J K−1 mol−1 and ΔV* = – (2.2 ±
In this paper, we consider precoder design for multiuser multiple-input-multiple-output (MIMO) Gaussian broadcast (BC) channels and propose a generalized zero-forcing (GZF) precoder based on successive dirty-paper coding (DPC), i.e., the GZF-DP precoder. The GZF-DP precoder is an extension of the GZF-DP precoder designed earlier for multi-input-single-output broadcast (MISO-BC) channels, and also
We determine the properties of the binary star V106 in the old open cluster NGC6791. We identify the system to be a blue straggler cluster member by using a combination of groundbased and Kepler photometry and multi-epoch spectroscopy. The properties of the primary component are found to be Mp ~ 1.67M⊙, more massive than the cluster turn-off, with Rp ~ 1.91R⊙ and Teff = 7110 ± 100 K. The secondary
Pairing rotations and pairing vibrations are collective modes associated with a field, the pair field, which changes the number of particles by two. Consequently, they can be studied at profit with the help of two-particle transfer reactions in superfluid and in normal nuclei, respectively. The advent of exotic beams has opened, for the first time, the possibility to carry out such studies in medi
This paper presents a hysteretic (sliding mode) control IC for a buck DC/DC converter for use as an envelope tracking power supply to increase the efficiency of an RF power amplifier. The IC integrates a high-bandwidth error amplifier, a comparator with hysteresis, and a high-side driver for an external N-channel power MOSFET. The total control loop delay using the implemented IC is 35ns, this is
Massive MIMO has been shown to greatly improve spectral and transmit-energy efficiency. When implementing a massive MIMO system, one challenge is high hardware complexity. A solution is to reduce the number of radio frequency (RF) transceiver chains by performing antenna selection. However, a full RF switch that connects the antennas and RF chains can be highly complex and incurs significant loss
Information about when and where animals die is important to understand population regulation. In migratory animals, mortality might occur not only during the stationary periods (e.g. breeding and wintering) but also during the migration seasons. However, the relative importance of population limiting factors during different periods of the year remains poorly understood, and previous studies main
Background In pediatric patients, computed tomography (CT) is important in the medical chain of diagnosing and monitoring various diseases. Because children are more radiosensitive than adults, they require minimal radiation exposure. One way to achieve this goal is to implement new technical solutions, like iterative reconstruction. Purpose To evaluate the potential of a new, iterative, model-basBackgroundIn pediatric patients, computed tomography (CT) is important in the medical chain of diagnosing and monitoring various diseases. Because children are more radiosensitive than adults, they require minimal radiation exposure. One way to achieve this goal is to implement new technical solutions, like iterative reconstruction.PurposeTo evaluate the potential of a new, iterative, model-based
The paper, titled “Human Trafficking: Analysis of Belarusian legislation on Human Trafficking in the scope of International Human Rights Law”, aims to discuss the gradual development of Human Trafficking Law, since its beginning up to nowadays, thus trying to show the main shifts in Human Trafficking Law, different approaches, conceptions and definition and analyze the Belarusian national mechanis
In the design of load-bearing building structures computer programs for analysis and design are frequently used. The programs are both 2D and 3D, where the latter is relatively new in the construction sector. For a 3D application, more phenomena can be taken into account, but on the other hand, the work required to build a model is more comprehensive. The purpose of this work is to investigate whe
Spatial planning of Blue-Green Infrastructure (BGI) should ideally be based on well-evaluated and context specific solutions. One important obstacle to reach this goal relates to adequate provisioning of data to ensure good governance of BGI, i.e., appropriate planning, design, construction, and maintenance. This study explores the gap between data availability and implementation of BGI in urban p
2 March 2026 09:45 to 15:30 | Workshop A workshop on acoustic probing and natural and artificial decision making underwater and in air – from dolphins and bats to drones and AUVs. This one day (“fika-to-fika”) workshop by Lund University Profile Area Natural and Artificial Cognition brings together researchers from across the NAC Plane* who are working on cognition, decision making, robots and AI
https://www.staff.lu.se/calendar/workshop-dolphins-decision-making-robots-and-ai - 2026-07-06
10 juni 2026 12:00 till 13:00 | Seminarium Topic: The Challenges of Generative AI for Democracy – Trust, Transparency, and Accountability in an AI-Infused Information LandscapeWhen: 10 June, 2026 12.00 to 13.00 CETWhere: Online - link by registration Speaker: Olof Sundin, Information Studies, Lund UniversityAbstractThis presentation examines the risks generative AI poses to democratic societies, f
25 september 2025 09:30 till 18:00 | Seminarium The symposium brings together a range of artistic practices and perspectives in order to interrogate how live performance engages with the here and now. What happens in moments when the now exceeds a possible response, the urgency is greater than the means, when words lose meaning and are unable to perform? What is performance transformed to then? Du
https://www.lu.se/evenemang/critical-now-performance-symposium - 2026-07-06
Traffic models can be used to study evacuation scenarios during wildland-urban interface fires and identify the ability of a community to reach a safe place. In those scenarios, wildfire smoke can reduce visibility conditions on the road. This can have serious implications on the evacuation effectiveness since drivers would reduce their speed in relation to the optical density on the road. To date
