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Background: The contribution of endothelial injury in the pathogenesis of COVID-19-associated acute respiratory distress syndrome (ARDS) and resulting respiratory failure remains unclear. Plasma endostatin, an endogenous inhibitor of angiogenesis and endothelial dysfunction is upregulated during hypoxia, inflammation and progress of pulmonary disease. Aim: To investigate if plasma endostatin is as
Nemo-like kinase (NLK) is a member of the mitogen-activated protein kinase family of kinases and shares a highly conserved kinase domain with other mitogen-activated protein kinase family members. The activation of NLK contributes to the pathogenesis of Diamond–Blackfan anemia (DBA), reducing c-myb expression and mechanistic target of rapamycin activity, and is therefore a potential therapeutic ta
Signal transduction in response to growth factors is a strictly controlled process with networks of feedback systems, highly selective interactions and finely tuned on-and-off switches. In the context of cancer, detailed signaling studies have resulted in the development of some of the most frequently used means of therapy, with several well established examples such as the small molecule inhibito
BACKGROUND: A third follow-up study, mean 40.7 years after uveitis onset, of a cohort originally consisting of 55 Swedish patients with uveitis associated with juvenile arthritis.METHOD: A retrospective study of the patients' ophthalmic medical records. The results were compared to those of the same cohort previously studied at mean 7.2 and 24.0 years after uveitis onset. In the present follow-up
Background and ObjectivesEEG is widely used for prediction of neurologic outcome after cardiac arrest. To better understand the relationship between EEG and neuronal injury, we explored the association between EEG and neurofilament light (NfL) as a marker of neuroaxonal injury, evaluated whether highly malignant EEG patterns are reflected by high NfL levels, and explored the association of EEG bac
Objective: To assess the quality of maternal and newborn care (QMNC) in countries of the former Yugoslavia. Method: Women giving birth in a facility in Slovenia, Croatia, Serbia, and Bosnia-Herzegovina between March 1, 2020 and July 1, 2021 answered an online questionnaire including 40 WHO standards-based quality measures. Results: A total of 4817 women were included in the analysis. Significant d
Within the field of cell biology, an essential tool is to deliver molecules to cells to manipulate cell behaviour and function. This enables the study of, for example, how a specific change in a cellular process contributes to a disease state. However, cells have barriers, such as the cell membrane, that need to be overcome for the molecules to have an effect. Current transfection methods, such asWithin the field of cell biology, an essential tool is to deliver molecules to cells to manipulate cell behaviour and function. This enables the study of, for example, how a specific change in a cellular process contributes to a disease state. However, cells have barriers, such as the cell membrane, that need to be overcome for the molecules to have an effect. Current transfection methods, such as
Increasing CO₂ emission is considered as the main reason for global warming in the world. One of the reasons for producing CO₂ is using of fossil-based materials in the construction projects. This study intends to assess the using bio-based materials instead of fossil-based materials for the thermal insulation layer of the external walls and roofs. Another focus of this project is using green conc
Introduction: Our objective was to evaluate the association of early-pregnancy body mass index (BMI) in women with gestational diabetes mellitus (GDM) with maternal, delivery, and child outcomes, and compare with pregnancies without diabetes in southeastern Sweden, including after a surge of non-European immigration. Material and Methods: A retrospective population-based observational study of all
Background There is a lack of contemporary data describing patients with left ventricular (LV) systolic dysfunction post myocardial infarction (MI) in terms of symptom burden and secondary prevention measures. The aim of this study was to describe patients with various degrees of LV systolic dysfunction after a first MI, their symptom burden, quality of life and adherence to recommended secondary
BackgroundIntravenous immunoglobulins (IVIG) have been suggested as an adjunctive treatment in streptococcal toxic shock syndrome (STSS), but there are no conclusive trials. In southern Sweden, IVIG is routinely used in certain hospitals but not in others. We hypothesized that this would resemble a natural experiment, and aimed to evaluate the effect of IVIG in STSS patients.MethodWe conducted a p
Objective To update the epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) in a defined geographical area of southern Sweden.Methods The study area comprised 14 municipalities with a combined adult population (≥18 years) of 623 872 in 2019. All cases diagnosed with AAV in 1997–2019 in the study area were included in the estimate of incidence. Diagnosis of AAV was veri
PurposeAntimicrobial resistance increases with the use of broad-spectrum antibiotics. Studies evaluating antibiotic stewardship are in high demand. Is piperacillin/tazobactam non-inferior to carbapenems regarding 30-day mortality among patients with bloodstream infections caused by extended-spectrum beta-lactamase-producing Enterobacterales?MethodsThis retrospective, multicenter, non-inferiority,
Background In congenital aortic stenosis (CAS), commissurotomy is an option in patients not suitable to receive a valve prosthesis. However, there is often a need for future additional interventions on the aortic valve. The fate of the aortic valve is, however, essentially unknown. This study reports the need for reinterventions after surgical commissurotomy, based on a national register. Material
Anorthoscopic vision: Designing and Sensing the Future Tom O’Dell As a means of thinking about the future and issues of uncertainty, I would like to take my point of departure in a project I completed a few years ago (O’Dell 2013) concerning plans to develop a huge particle sciences facility in Lund, called the European Spallation Source (ESS). I was the only ethnologist working with a team of 1
This study examines the relationship between critical thinking and the use of Big Data Analytics (BDA) in decision-making among white-collar professionals. It focuses on three key areas: the influence of BDA reliance on critical thinking, the connection between professional experience and cognitive reasoning, and the demands of strategic decision-making compared to tactical and operational roles.
Uppsatsen har som syfte att kritiskt granska försvarlighetsbedömningen och excessbedömningen som görs i nödvärnssituationer. Ett psykologiskt perspektiv används för att analysera huruvida Högsta domstolen har skapat en för långtgående skyldighet att fly istället för att försvara sig med våld. Det är endast nödvärn vid brottsligt angrepp på person som behandlas. Jag använder mig av den rättsdogmatiThe purpose of this essay is to critically examine the Supreme Court’s judgments regarding the justifiability of self-defense and excessive self-defense. A psychological perspective is applied to analyze if the Supreme Court has created a too extensive obligation to escape instead of using violence to defend oneself. This essay only covers self-defense from criminal attacks on a person. I use a le
AI och algoritmer förutspås revolutionera stora delar av samhället. Den snabba tekniska utvecklingen har redan idag nått arbetslivet och används i allt större utsträckning av arbetsgivare för att rekrytera personal, utöva arbetsledning och fatta viktiga arbetsrelaterade beslut. I gig-ekonomin och plattformsföretagen är användningen särskilt utbredd och algoritmer används för allt från att administAI and algorithms are predicted to revolutionize large sections of society. The rapid technical development has already reached working life and is increasingly used by employers to recruit staff, exercise management and make important work-related decisions. In the gig economy and platform companies the use is particularly widespread and algorithms are used for purposes ranging from managing the
