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Type-2 diabetes (T2D) is a complex disease characterized by insulin resistance in target tissues and impaired insulin release from pancreatic beta cells. As central tissue of glucose homeostasis, the pancreatic islet continues to be an important focus of research to understand the pathophysiology of the disease. The increased access to human pancreatic islets has resulted in improved knowledge of
In the present study, a new and versatile liquid-phase microextraction method is described. This method requires very simple and cheap apparatus and also a small amount of organic solvent. Eight microliters of 1-undecanol was delivered to the surface of solution containing analytes and solution was stirred for a desired time. Then sample vial was cooled by inserting it into an ice bath for 5 min.
We present a comparative analysis of the unfolding and inactivation of three cutinases in the presence of guanidine hydrochloride (GdnHCl) and bis(2-ethylhexyl) sodium sulfasuccinate (AOT). Previous investigations have focused on the cutinase from Fusarium solani pisi (FsC). In addition to FsC, the present study includes the cutinase from Humicola insolens (HiC) and a mutant variant of HiC (mu HiC
Pheromones are central to the mating systems of a wide range of organisms, and reproductive isolation between closely related species is often achieved by subtle differences in pheromone composition. In insects and moths in particular, the use of structurally similar components in different blend ratios is usually sufficient to impede gene flow between taxa. To date, the genetic changes associated
Popular Abstract in Swedish Mjölk anses som det enda flytande livsmedlet som på naturlig väg innehåller de tre fundamentala byggstenarna, fett, protein och kolhydrater, vilket definierar ett livsmedel näringsmässigt. Majoriteten av världens vuxna befolkning är dock tvungen att ha en begränsad konsumtion av mjölk då toleransen för dess kolhydrat, laktos, minskar med vuxen ålder. Detta beror främst This thesis deals with the fermentation characteristics of lactic acid bacteria (LAB) in oat-based suspensions, with formulation work of fermented products based on oat and with nutritional studies of these products. Changes in structure in terms of viscosity and ropiness were studied when exopolysaccharide (EPS)-producing LAB strains, namely, Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772,
Popular Abstract in Swedish De flesta produkter som vi dagligen använder tillverkas genom att utnyttja fossila råvaror som olja, kol och naturgas. Ett stort problem är att dessa råvaror bara finns i begränsade mängder i naturen, vilket medför att de förr eller senare tar slut. Dessutom medför förbränning av fossila råvaror att det bildas miljöskadande gaser (t.ex. koldioxid) som ansamlas i atmosfäOne of the major challenges facing the world today is the reduction of our dependency on fossil resources as their exploitation has severe negative effects on the environment. One way of realizing this is to utilise the components of lignocellulosic biomass to a greater extent as feedstock for various industrial products. However, such utilisation requires the extraction of the biopolymers from th
Popular Abstract in Swedish Ny innovativ processdesign har resulterat i två processer som kan göra tillverkningen av förnyelsebara plaster och bränslen konkurrenskraftiga mot dagens fossila alternativ. Den nya designen har gjort vissa processteg upp mot 40 gånger så effektiva som med dagens teknik. Vikten av att ställa om dagens samhälle, som till stor del är beroende av fossila resurser, till eIt is important to replace fossil resources such as oil, coal and natural gas with renewable raw materials for the production of materials and fuels in order to reduce environmental impact. Furthermore, these raw materials should preferably be residues, e.g. agricultural or forest residues, in order not to compete with the production of human food and animal feed. High molecular weight arabinoxyla
Leaching of dissolved organic carbon (DOC) from the forest floor and transport in soil solution into the mineral soil are important for carbon cycling in boreal forest ecosystems. We examined DOC concentrations in bulk deposition, throughfall and in soil solutions collected under the O and B horizons in three Norway spruce stands along a climatic gradient in Sweden. Mean annual temperature for the
Context. Positions and proper motions of Gaia sources are expressed in a reference frame that ideally should be non-rotating relative to distant extragalactic objects, coincident with the International Celestial Reference System (ICRS), and consistent across all magnitudes. For sources fainter than 16th magnitude, this is achieved through Gaia's direct observations of quasars. At brighter magnitud
Nonverbal behaviour has an important function in team sports, but research is limited. Adopting a psychological momentum (PM) framework, this study explores the relationship between a team’s history of events, nonverbal post-shot celebrations in the form of gestures and touch shown by the shooter after scoring, and subsequent team performance during handball matches. A naturalistic design with sys
Context. The prediction of the Planck-constrained primordial lithium abundance in the Universe is in discordance with the observed Li abundances in warm Population II dwarf and subgiant stars. Among the physically best motivated ideas, it has been suggested that this discrepancy can be alleviated if the stars observed today had undergone photospheric depletion of lithium. Aims. The cause of this d
The debate on the industrial revolution (IR) has been focused on the incentives behind investment decisions and how the preliminary conditions for it appeared in England / Great Britain. One of the most famous theories to explain the IR is the one developed by Allen (2012, 2009b,a), who argues that the IR was British due to a unique combination of expensive labour and cheap energy, producing incen
Glomalin-related soil protein (GRSP) is known as an important microbial by-product which is crucial for preserving or accumulating soil organic carbon (SOC). However, the underlying mechanisms are not well understood. In this study, we investigated the chemical structures of GRSP and its relationship with SOC using 13C nuclear magnetic resonance (NMR) in three tropical forests. The three forests,
Absorption (mu (a)) and reduced scattering (mu (s)') spectra of turbid media were quanti fied with a noncontact imaging approach based on a Fourier-transform interferometric imaging system (FTIIS). The FTIIS was used to collect hyperspectral images of the steady-state diffuse reflectance from turbid media. Spatially resolved reflectance data from Monte Carlo simulations were fitted to the recorded
BACKGROUND: Takotsubo syndrome (TS) is a potentially life-threatening acute cardiac syndrome with a clinical presentation similar to myocardial infarction and for which the natural history, management, and outcome remain incompletely understood. Our aim was to assess the relative short-term mortality risk of TS, ST-segment–elevation myocardial infarction (STEMI), and non-STEMI (NSTEMI) and to iden
This cross-sectional case study investigates patterns of politicisation in election campaigns of the German Eurosceptic party Alternative für Deutschland (AfD) by means of a comparative multi-level analysis. It adds to the existing literature by examining the Eurosceptic elements of the party’s campaign communication across various decision-making levels. It examines EU issue salience, the dimensi
Ett avgörande om vårdnad, boende och/eller umgänge som inte följts kan verkställas enligt 21 kap. föräldrabalk (FB), förutsatt att det inte är oförenligt med barnets bästa. I sådant fall kan beslutet förenas med tvångsmedel i form av vitesföreläggande eller polishämtning. En ansökan om verkställighet ska avslås om det finns en risk att barnet far illa eller om barnet motsätter sig verkställighet oA decision on custody, resident and/or visitation that has not been followed can be enforced in accordance with Chapter 21 in the Children and Parent Code (föräldrabalk (1949:381)), provided it is not incompatible with the best interests of the child. In such a case, the decision can be combined with coercive measures in the form of an imposition of a conational fine or police retrieval. An applic
A combination of acoustic trapping and impedance spectroscopy for micrometer-sized objects is here presented for the first time. Acoustic trapping has proven to be a well-functioning method for non-contact immobilization and positioning of particles or cells in microfluidic channels. The combination with impedance spectroscopy allows for simultaneous electrical measurements on the trapped objects.
Förevarande arbete har som målsättning att utreda huruvida en förändring i dödsstraffsdebatten skedde under 1800-talet och 1900-talets första decennier intill dess avskaffande 1921. För att på ett bra sätt kunna företa en sådan granskning inleds uppsatsen med ett avsnitt som kortfattat beskriver den svenska historien för att därefter följas av ett avsnitt enbart rörande dödsstraffsdebatten och avThe goal of the following essay is to investigate any changes in the debate regarding the Swedish death penalty which took place during the 19th century and the beginning of the 20th century until the death penalty was abolished in 1921. To be able to undertake such an investigation it’s my personal belief that one first must know the basics of Swedish history. Therefore the essay starts with a
