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OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured

The purpose of this dissertation was to examine what Smart City concept entails in practice rather than a theory, with a clear secondary focus on digitization and collaboration as the means to deliver successful Smart City projects. This project sheds light on the public actor’s managerial perspective on many actual topics for the globalized world, where cities play a pivotal role. By interviewing

I mitt kommande yrke som kyrkomusiker i Svenska kyrkan kommer jag att leda församlingens musik och i församlingen kommer jag att möta människor som är sångovana eller har svårigheter med att sjunga. I min uppsats redogör jag för mitt arbete med att hjälpa dessa människor att hitta och förbättra sin sångröst, som är ett primärt instrument i församlingens musicerande och gudstjänstliv. Genom studier

https://www.campusonline.lu.se/en/technical-support - 2026-05-13

There are different ways to bring a cypress tree to mind. We might think about atree, speak about it, or imagine it. The cypress might come to us unbidden inmemory, or in dream. But we might also see a cypress tree, or feel its branches inour hands. This way of bringing the tree to mind is distinctive because the treeitself seems to be present in our experience. Our experience has perceptualpresen