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Our ability to genetically engineer microorganisms is growing rapidly. We can perform small, precise modifications using techniques such as CRISPR-Cas9 to whole-virome synthesis and/or large genetic insertions. These advances reduces the threshold for synthetic biology to be employed maliciously. Preparations against pandemics or deliberate biological attacks currently rely on taxonomic identifica
Denna uppsats syftar till att stärka förståelsen för dynamisk prissättning och dess möjligheter genom att undersöka effekterna på samhällsnyttan om dynamisk prissättning används inom kollektivtrafiken. Kollektivtrafiken har en stor påverkan på samhällsnyttan och är ett verktyg som kan bidra till att minska social exkludering. Det är därför av stor betydelse att utbudssidan av kollektivtrafiken max
The telecom industry falls among one of the most progressive markets that operates at the level of advanced technologies and has the fastest rate of growth all over the world, including from the perspective of 5G technology, the integration of digital products, and the constant increase in demand for broadband internet. In such a competitive environment, customer attrition has been known to be a m
The existing Power Supply Unit (PSU) at Axis Communication contains a fully discrete solution that lacks flexibility for future updates. This research aims to address critical challenges by exploring methods to enhance speed, reduce PCB area, and introduce flexibility to the existing hardware solution. The approach involves replacing hardware functionalities within the control unit with software-c
The use of technology, specifically machine learning, to address complex issues in developing regions has become increasingly prominent. In the context of wildlife conservation, combating poaching has emerged as a significant application of such technology. This research project aims to develop machine-learning-based low-cost antipoaching solutions. It presents three case studies, each exploring a
Introduction: PARP14 belongs to the superfamily of PARPs that perform ADP-ribosylation of target proteins. The enzyme is involved in many cellular processes, including regulation of glycolysis, protein degradation, and genomic reparation. Background: PKM2 has been shown to be regulated indirectly by PARP14 to promote the Warburg effect. This describes an alternative glycolysis that cancer cells a
Research on monoclonal antibody (mAb) has considerably gained importance during the last decades, not only for cancer therapy but also for its importance in variety of fields. Unfortunately, the development phase can take several years before obtaining FDA approval, hence alternative approaches that could potentially shorten this timeline are critically needed. For instance, flow-injection analysi
Wildlife globally is under threat, especially in sub-saharan Africa, with poaching as a major factor. The animals are a part of a biological ecosystem and also a key for tourism and hence the economies of many African countries. To help preserve wildlife and prevent poaching, technologies such as AI cameras and dashboards offer a crucial tool. The technologies need to be purchased and distributed,
The Hawkes process, also referred to as a self-exciting point process, is a class of point processes where the intensity is conditioned on previous events. More specifically, an event occurrence excites the process, temporarily increasing the probability of more events occurring. One application of Hawkes processes is to model occurrences of crimes, such as burglaries or shootings. The present the
Bakgrund: Psykisk ohälsa står för nästan hälften av sjukfrånvaron i Sverige, varav de flesta fall beror på stressrelaterad ohälsa. Arbetsterapeutiska interventioner är ett alternativ för individer med stressrelaterad ohälsa då de kan vara i behov av förändringar som kan främja en god aktivitetsbalans. Syfte: Undersöka arbetsterapeutiska interventioner inom primärvården för vuxna individer med strBackground: Mental illness accounts for almost half of sickness absence in Sweden, of which most cases are due to stress-related illness. Occupational therapy interventions are an option for individuals with stress-related illness as they may be in need of changes that can promote a good activity balance. Aim: To explore the effects of occupational therapy interventions in primary care for adults
Administration av T-celler via en artificiell vävnadsrekonstruktion är en lovande metod för att behandla inoperabla tumörer. Traditionella vävnadsrekonstruktionsmaterial saknar den komplexitet som finns hos det extracellulära matrixet (ECM), där celler vanligtvis lever. Ett alternativ är då att använda decellulariserat ECM (dECM) som material när man skapar den artificiella vävnadsrekonstruktionenT-cell administration via a scaffold is a promising tool for treatment of inoperable solid tumours. Traditional scaffold materials lack the complexity of the extracellular matrix (ECM) that cells normally grow in. An alternative is to instead use decellularised ECM (dECM) from biological tissue to create the scaffold. By making the scaffold via 3D-printing, its construction can also be a part of m
The aim of this bachelor degree project is to design a modular luminaire with a longer lifespan, in order to reduce consumption. The project aims to explore how design can contribute to sustainable development by creating a durable and adaptable lighting solution. The luminaire is versatile and can either be hung from the ceiling, mounted on the wall, or placed on a table. It can be expanded
This thesis explores the use of Hydra for real-time reconstruction of environments in extended reality (XR). The development of the prototype was performed in an iterative manner. Three iterations were executed, each resulting in a prototype with improvements related to the takeaways from the preceding prototype. The final prototype consisted of two scenes. The first scene consisted of rendered f
A Free Electron Laser (FEL), is a device that generates extremely coherent and brilliant radiation using electrons accelerated to relativistic velocities in a particle accelerator. The process utilises similar equipment to what is used at a synchrotron source like MAX IV, but in addition there is an interaction between the relativistic electron beam and the generated radiation to achieve an expone
Every company on the verge of market entry faces a myriad of tough choices. Few are as fateful as which go-to-market strategy a company chooses to establish a foothold, entailing crossroads such as whether to prioritise growth or profitability and how to structure sales. This is the position that the white label insurtech Alpha Insurance find themselves in, with a go-to-market strategy in place bu
The incidence of oropharyngeal cancer (OPC) is increasing in developed countries, and OPC is associated with human papillomavirus infection [1, 2]. Immunotherapies show promise as an end-stage treatment for immune-infiltrated tumours. They are only efficacious in 18% of patients leading to investigation of the immune compartment to comprehend which factors contribute to effective treatments. Anti-
The shift towards more environmentally friendly means of transportation is a pivotal change that needs to be made, to save the environment. The transportation sector alone constitutes roughly a third of all greenhouse emissions in Sweden, making it one of the leading contributors to all greenhouse gases. With ever-growing climate awareness, the idea of adopting a greener approach to protect the pl
