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The p53 tumor suppressor gene regulates growth arrest and apoptosis after DNA damage. Recent studies suggest that p53 is inactive in vascular smooth muscle cells (VSMCs) in human angioplasty restenosis, promoting VSMC accumulation and vessel stenosis. In contrast, the success of irradiation (brachytherapy) for in-stent restenosis argues that DNA-damage p53 responses are intact. We examined p53 exp
The immunogenicity of biological therapeutic products is currently a high profile regulatory and biotechnology industry issue. The immune responses raised against biotechnology products range from the benign, to affecting product efficacy, to those that have serious deleterious clinical impact. The most widely used marker of immunogenicity is the detection and measurement of antibody responses ind
We discuss the associated cc¯ and l+l- pairs production in ultraperipheral heavy-ion collisions at high energies. Such a channel provides a novel probe for double-parton scattering (DPS) at small x enabling one to probe the photon density inside the nucleus. We have derived an analog of the standard central pp pocket formula and studied the kinematical dependence of the effective cross section. Ta
Sporadic Alzheimer's disease (sAD) is the most prevalent neurodegenerative disorder with no cure. Patients typically suffer from cognitive impairment imprinted by irreversible neocortex and hippocampal degeneration with overt synaptic and neuron dysfunction. Insulin-like growth factor 1 (IGF1) has proven to be a potent neuroprotective molecule in animal models of age-related neurodegeneration. In
Background: It has been estimated that approximately 20% of all Swedish children grow up with parents having alcohol problems, which may result in negative outcomes among these children. Therefore, most Swedish municipalities provide resources for support, but at the same time figures reveal that not even 2% receive support, mainly due to difficulties in identifying and recruiting these children i
Popular Abstract in English This thesis is about industrialised house-building, put in a strategic perspective. Industrialised house-building is in the thesis described as a process- and product-oriented concept that can serve as an alternative to traditional project-oriented house-building methods and principles. It is seen as an integrated, multi-disciplinary concept that requires an establishedIndustrialised house-building has received increasing attention within both the construction industry and the scientific community during the last 15 years. However, industrialisation of house-building is not a new phenomenon, it has been applied to various extents throughout modern history, although the understanding and descriptions of it have developed over time. Scientifically, industrialised
Monoclonal gammopathy of undetermined significance (MGUS) was identified in 3.2% of 21 463 residents of Olmsted County, Minnesota, 50 years of age or older. The risk of progression to multiple myeloma, Waldenstrom's macroglobulinemia, AL amyloidosis or a lymphoproliferative disorder is approximately 1% per year. Low-risk MGUS is characterized by having an M protein < 15 g/l, IgG type and a normal
This thesis explores the transformative impact of social media platforms on communication and representation. More specifically, it investigates the themes of motherhood portrayed in the YouTube videos of Swedish party leaders and how these themes relate to the process of democratic representation. The research centers around former Center party leader Annie Lööf and the current Christian Democrat
With the calls raised in “buy clean” within green public procurement (GPP) for construction, recently, low-carbon procurement (LCP), the subset GPP is getting more and more attention. However, not many academic publications explore LCP for public buildings or infrastructure projects. Moreover, it appears that little research further investigates its influence on the decarbonization of hard-to-abat
Att beröva en annan människa livet är ett av de grymmaste och mest förödande brotten som en människa kan begå. Det berövar en människa den mest grundläggande mänskliga rättigheten – rätten till liv. Ett sådant brott ska bemötas med ett hårt straff. Denna uppsats syftar till att redogöra för hur livstidsstraffets tillämpning i Sverige har förändrats under de senaste åren pga. flera betydande ändrinDepriving another human life is one of the cruelest and most devastating crimes that a human being can commit. It denies a human being the most fundamental human right – the right to life. Such a crime must be dealt with a severe penalty. The purpose of this thesis is to describe how the application of the life sentence in Sweden has changed over the past years because of several significant amend
The question this thesis seeks to address is the legal circumstances under which an individual can be subject to criminal responsibility for committing the crime of aggression. This question is primarily considered in the context of a British national, given the particular situation of the United Kingdom as a State Party to the Rome Statute which has not ratified or accepted the 2010 Kampala Amend
Georgia is facing social and economic challenges and at the same time there are signs that more pressure is put on the environment and natural resources. Georgian industry is energy- intense and encompassing deregulations have put even more stress on the environment. How to combine economic and social goals with environmental concerns has been a hotbed for disputes in Georgia. A recognized approac
This paper focuses on the cessation of the Angolan refugees in Zambia and South Africa. The paper aims to identify the problems concerning the cessation for a group of ref-ugees and will show that even thought the group as a whole might not have reason to fear for their life, there could be individuals within the group who have. Furthermore, the essay alerts how arbitrary the process to get an alt
In recent years, research into internet-based cognitive behavioral therapy (iCBT) has suggested that therapist-guided digital interventions have greater engagement, adherence, and effectiveness than self-directed digital therapies. While research has focused on the effectiveness of, and adherence to, these interventions, less attention has been paid to their implementation in practice and what asp
Background Treatment-related toxicity and quality of life (QoL) considerations are important when counseling patients with localized prostate cancer (PCa). Objective To determine the incidence and longitudinal pattern of late genitourinary (GU) toxicity and QoL after high-dose, intensity-modulated radiotherapy (IMRT). Design, setting, and participants A total of 268 patients with localized PCa wer
Background: PET/CT may be more helpful than CT alone for radiation therapy planning, but the added risk due to higher doses of ionizing radiation is unknown. Objective: To estimate the risk of cancer induction and mortality attributable to the [F-18]2-fluoro-2-deoxyglucose (FDG) PET and CT scans used for radiation therapy planning in children with cancer, and compare to the risks attributable to t
The European Union is originally an economic organization that has developed into including more social and cultural questions. These questions are especially important when the Union expands with so many different cultures and traditions to take into concideration. I have from an identity perspective studied the relation between the European Union and the candidate country of Turkey. Using theor
