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For Alligator Bioscience AB, a company developing immunotherapeutic antibodies, it is crucial to efficiently evaluate a large number of potential drug candidates at an early stage. The in-house developed RUBYTM concept, combining monoclonal antibodies into bispecific antibodies without lead optimization, requires implementation of high-throughput technologies. Restriction enzyme digestion, used fo
Purpose/Objective(s): To report the efficacy and utility of PSMA-based molecular targeted imaging in localized prostate cancer using 111In-J591 SPECT and 89Zr-J591 immuno-PET.Materials/Methods: Initiated in 2010, two sequential phase 0 prospective studies were performed on a total of 19 patients evaluating the roles of 111In-J591 SPECT and 89Zr-J591 immuno-PET. All patients had a baseline MRI foll
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within
The value of communication in the pop music industry In this study, we aim to examine communication, and mainly promotion, within the pop music industry. The purpose is to investigate the value communication practitioners provide for artists and what communicative value independent artists provide for themselves. It can be argued that the relevance of communication practitioners within the music i
Smittspridningen av viruset COVID-19 i början av år 2020 innebar att stater blev tvungna till att vidta restriktioner som lett till stängning av många skolor och bibliotek. Trots nedstängning, har skolor i Sverige kunnat fortsätta undervisningar digitalt. Det finns dock upphovsrättsliga utmaningar med digitala undervisningar, med anledning av upphovsmannens ensamrätt. Syftet med uppsatsen är att uThe outbreak of COVID-19 in the beginning of 2020 has led to states imposing restrictions that cause many schools and libraries to close. Despite the lockdown, it has been possible for schools in Sweden to continue their lectures digitally. However, there are copyright issues to address in the transition to digital teaching because of the right holder's exclusive rights to his or her works. Th
Introduction: To gain competitiveness, industrial focuses are addressed towards product quality improvement, product time compression, costs and lead-time reduction. Nowadays, these diverse goals cannot be achieved by an isolated organizational switch but throughout an aimed supply policy. In particular, an integrated view to manage physical goods and virtual information from suppliers to customer
This thesis critically explores gender equality in international development, focusing on Guatemala amidst resurgent right-wing politics, volatile commitment, and gender backlash. It investigates how institutions like the Food and Agriculture Organization (FAO) navigate gender mainstreaming in a country with fluctuating dedication to gender equality. Through mixed methods, including thematic analy
The aim of this study was to examine how professionals working in residential care units for unaccompanied children, construct and understand integration and culture. The study was built on empirics which was the result of five semi-structured interviews held with professionals working in this field. The interviews included both professionals working in the public sector and professionals working
Syftet med studien är att få en ökad förståelse för de sociala interaktionerna mellan chefen och medarbetarna utifrån ett medarbetarperspektiv. För att besvara syftet valde vi att utgå från följande frågeställning: hur kan chefens beteende och ledarskap påverka hur medarbetarna upplever sin trivsel på arbetsplatsen? Den teoretiska referensramen har haft fokus på företagskultur, ledarskap och triv
Lobbying in the European Union (EU) is a highly discussed and disputed phenomena. The main focus on lobbying in the EU is concerned with how and why lobbyists interact with institutional actors, rather than exploring both sides of the occurrence. The aim of this thesis is to explore and compare whether the European Commission and the European Parliament have different demands for lobbying input. T
The Solar energy is playing a fundamental role in the transition to a low carbon electricity production system. Driven by rapidly decreasing prices for solar installations in the last years, the solar energy market in Europe is currently undergoing a transformation. Subsidies such as feed-in tariffs are being phased out and replaced with the possibility to self-consume solar energy, earning a prof
Den teoretiska utgångspunkten för denna teoriutvecklande studie ligger i Galtungs resonemang om det utökade våldsbegreppet och det strukturella våldet. Vi utvecklar här en egen metod för mätning av strukturellt våld som vi sedan applicerar på alla stater för vilka det finns tillgänglig statistik. Det strukturella våldet i vår empiriska undersökning utgörs av en politisk, en ekonomisk och en kult
Den globala finanskrisen har inneburit att förtroendet för finansmarknaden riskerar att allvarligt skadas. Det minskande förtroendet för banksektorn på ett globalt plan har även lett till finansierings- och upplåningsproblem för de svenska bankerna, trots att de förefaller relativt likvida i en internationell jämförelse. För att öka stabiliteten i finanssektorn införde Sverige under 2008, i likhet
One of the interim targets in the Swedish national Good Built Environment objective states that biological treatment of source separated food waste should be a priority. The goal of biologically treating 35 percent of all municipal food waste in 2010 was not achieved, and a proposed target for 2015 raises the bar even further (40 percent). The way the proposed milestone target is phrased excludes
Är föräldrar det stora problemet inom barnidrott? Syftet med studien var att undersöka föräldraengagemang inom barnidrott med fokus på föräldrars upplevelse, vad de ansåg som bra engagemang för att främja barnidrott, och vilken roll idrottsföreningar spelar i detta sammanhang. En kvalitativ ansats användes för att ge en djupare förståelse av fenomenet. Data inhämtades genom semistrukturerade inter
This research investigates the contribution of local currencies to sustainability. I look at a specific local currency scheme (the Bristol Pound, in Bristol, United Kingdom) through a transitions perspective, employing a Transitions Evaluation Framework, Multi-Level and Multi-Phase Perspectives to conduct my analysis. I use a qualitative triangulation approach to collect data, namely semi-structur
Bevisvärdering i brottmål utgörs av en intresseavvägning mellan två grundläggande men till viss del motstående intressen om å ena sidan en effektiv brottsbekämpning och alla människors rätt till skydd under lagen, och å andra sidan det starka kravet på rättssäkerhet för personer som är anklagade för brott. Bevisvärderingen vid våldtäktsbrott är ofta föremål för svåra bedömningar och dessa målThe process of evaluation of evidence in criminal cases is based on a complex conflict of interests, with on one hand the interest of efficient prosecution and all individuals’ equal right to protection under the law, and on the other hand the security of a just trial and the presumption of innocence until proven guilty. The courts’ processes of evaluation of evidence in cases of rape have bee
Background: Persons with dementia receive health care and social services from a wide range of professional care providers during the disease trajectory, presenting risks of miscommunication, duplication and/or missed nursing interventions. Accordingly, the aim of this study was to investigate professional care providers' views on conditions for best practice in terms of collaboration and improvem
