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Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe and sometimes life-threatening disease characterized by viral invasion of the central nervous system with symptoms of neuroinflammation1,2. As with other orthoflaviviruses—enveloped, arthropod-borne RNA viruses—host factors required for TBEV entry remain poorly defined. Here we used a genome-scale CRISPR–Cas9-based

Nanoreactors have attracted extensive research and attention in the field of catalysis due to their unique surface/interface structures and physicochemical properties. However, conventional nanoreactors have limited catalytic performance due to the confinement of their active components in the “nanochamber”. Herein, low-content active metal (AM, AM = Pd, Cu) decorated yolk-shelled FeCoNiOx (AM/FeC

Let v1 and v2 be two distinct vertices of an equilateral tree T0. Let ϕN(i) (i=1,2) be the characteristic functions of the Sturm-Liouville problem on T0 rooted at vi with Neumann conditions at the root and let ϕD(i) (i=1,2) be the characteristic functions of the Sturm-Liouville problem on T0 with Dirichlet conditions at the root. We prove that if attaching any tree to T0 at the vertices v1 and v2

While pregnancy clearly reduces the risk for Alcohol Use Disorder (AUD) onset, we know less about the impact on AUD risk of having young children and how these effects vary across maternal age and level of maternal AUD genetic risk. Therefore, in 1.2 million parous Swedish women born 1960-1995, we examined those with a first registration for AUD between ages 15-40 while first pregnant, or while ra

Work and working conditions are fundamental social determinants of health. Climate change poses an urgent and growing threat to workers' health, through both direct exposure to environmental hazards and indirect exacerbation of social and health inequalities. Occupational health, which focusses on the promotion of mental and physical health and well-being of workers, is a key but often overlooked

Metastable nonradiative centers (supertraps) are significant energy loss channels in perovskite optoelectronic devices. In their active state, supertraps induce substantial energy loss through nonradiative recombination of free charge carriers. Transitions between active (energy loss) and passive (no energy loss) states result in photoluminescence (PL) blinking on timescales from milliseconds to s

Cubosomes─colloidal dispersions of lipid inverted bicontinuous cubic phases─are promising nanosystems for advanced drug delivery applications. Here, we report on a microfluidic hydrodynamic flow-focusing approach for solvent exchange that enables the preparation of cubosomes with tunable size. The approach involves a preliminary step where the lipid phytantriol, the main building block, is first d

Objective: Survivors of childhood, adolescent, and young adult (CAYA) cancer have an increased risk of metabolic syndrome (MetS). MetS describes the clustering of cardiovascular risk factors including overweight or obesity, hypertension, (pre)diabetes, and dyslipidaemia. While associated cardiovascular sequelae can be serious, MetS is preventable, manageable, and potentially reversible with the ap

Certified randomness guaranteed to be unpredictable by adversaries is central to information security. The fundamental randomness inherent in quantum physics makes certification possible from devices that are only weakly characterized, i.e., requiring little trust in their implementation. It was recently shown that the amount of certifiable randomness can be improved using the so-called entropy ac

ObjectiveTo compare speech outcomes in 4 groups of 5-year-olds with cleft of the hard and soft palate: with Robin sequence without additional conditions (RS−), with Robin sequence with additional conditions (RS+), without Robin sequence with additional conditions (CP+), and without Robin sequence without additional conditions (CP−).DesignRegistry-based cohort study.SettingRegional public care univ

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with a heterogenous clinical picture. This study aimed to link genetic SLE predisposition with relevant clinical manifestations. Method: Datasets best corresponding to the 11 American College of Rheumatology 1982 (ACR-82) classification criteria for SLE in a large, public database (FinnGen consortium, >218,000 individuals) wer

Background: This study aimed to compare the effect on postoperative complications of combined prehabilitation targeting predefined co-existing risky SNAP factors with usual preoperative routines in surgical patients. Methods: This systematic review followed the PRISMA 2020 guideline and the protocol (CRD42022282611). Five databases were searched from inception to November 7, 2022 for randomised co

During graded exercise, systolic blood pressure (SBP) is expected to increase linearly, but other responses are observed. To date, a framework for algorithmic assessment of the shape of the SBP response is lacking, making its physiological and clinical relevance poorly understood. We aimed to algorithmically identify distinct SBP response shapes and analyze their association with clinical factors

Background: Standardised language tests provide a reliable framework for assessing language deficits in individuals with aphasia, but have long been lacking for various languages, including Swedish. The purpose of this study was to examine the diagnostic accuracy and establish the norm-references of the Swedish version of the Comprehensive Aphasia Test (CAT-S). Methods: Consecutive patients with a

AbstractBackground: The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensively and at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential roles in respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the centBackground: The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensivelyand at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential rolesin respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the central nervou

AbstractBackground: The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensively and at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential roles in respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the centBackground: The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensivelyand at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential rolesin respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the central nervou

Introduction: Familial risk of lung cancer (LC) is at the level of many common cancers (ca 2.0) but as cigarette smoking is the main cause of LC, it has remained undefined to what extent smoking contributes to the familial risk. We take advantage of the natural experiment of divorce. In Sweden, it has been customary that children stay with their mother after divorce. We thus hypothesize that only

Background: Chronic low-grade inflammation is a well-known risk factor for coronary heart disease (CHD) and future cardiovascular events. Anti-inflammatory therapy can reduce the risk of ischemic cardiovascular disease (CVD) events following myocardial infarction (MI). However, it remains unknown to what extent inflammation at the time of an acute event predicts long-term outcomes. We explored whe