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Subgap states are responsible for the low-bias transport features of hybrid superconducting-semiconducting devices. Here we analyze the local and nonlocal differential conductance of Coulomb-blockaded multiterminal superconducting islands that host subgap states with different spatial structures. The emerging patterns of their transport spectroscopy are used to characterize the possible topologica
Small-angle neutron scattering (SANS) experiments were conducted on cyclic and linear polymers of racemic and l-lactides (PLA) with the goal of comparing chain configurations, scaling, and effective polymer–solvent interactions of the two topologies in acetone-d6 and THF-d8. There are limited reports of SANS results on cyclic polymers due to the lack of substantial development in the field until
BACKGROUND: Inherited CDKN2A mutation is a strong risk factor for cutaneous melanoma. Moreover, carriers have been found to have poor melanoma-specific survival. In this study, responses to novel immunotherapy agents in CDKN2A mutation carriers with metastatic melanoma were evaluated.METHODS: CDKN2A mutation carriers that have developed metastatic melanoma and undergone immunotherapy treatments we
Objective: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). Methods: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient isc
Despite extensive studies, defining culture conditions in which hematopoietic stem cells can be expanded ex vivo has been challenging. Here we show that chemical inhibition of the NF- κB signaling pathway leads to a significant improvement of hematopoietic stem cell function from ex vivo cultured human umbilical cord blood derived CD34+ cells. We found a distinct peak of activation of the NF-κB pa
Floods constitute a major problem that cross geopolitical, administrative, and sectoral boundaries, and must as such be jointly governed by a web of actors. The patterns of social relations among these actors are fundamental for society's capacity to mitigate flood risk. The purpose of this study is to contribute to our understanding of flood risk governance by investigating the social organizatio
Groucho related gene 5 (GRG5) is a multifunctional protein that has been implicated in late embryonic and postnatal mouse development. Here, we describe a previously unknown role of GRG5 in early developmental stages by analyzing its function in stem cell fate decisions. By both loss and gain of function approaches we demonstrate that ablation of GRG5 deregulates the Embryonic Stem Cell (ESC) plur
Sweden has witnessed a significant increase in the rate of firearm-related homicide. We therefore aimed to study the characteristics of individuals suspected of homicide, attempted homicide, preparation to commit homicide as well as conspiracy to commit homicide with a firearm in Sweden. By using information from different registers, suspected individuals between 2000 and 2017 and aged 15 to 60 we
Background: Digital breast tomosynthesis (DBT) improves breast cancer (BC) detection compared to mammography, however, it is unknown whether this reduces interval cancer rate (ICR) at follow-up. Methods: Using individual participant data (IPD) from DBT screening studies (identified via periodic literature searches July 2016 to November 2019) we performed an IPD meta-analysis. We estimated ICR for
We report on charge transport across self-assembled monolayers (SAMs) of short tau peptides by probing the electron tunneling rates and quantum mechanical simulation. We measured the electron tunneling rates across SAMs of carboxyl-terminated linker molecules (C6H12O2S) and short cis-tau (CT) and trans-tau (TT) peptides, supported on template-stripped gold (AuTS) bottom electrode, with Eutectic Ga
Objective: To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden unaccounted for by the traditional stroke risk profile of individual patients and their long-term functional outcomes after a stroke. Methods: We included 890 patients who survived
Background: The aim of this study was to explore the risk of invasive colorectal cancer (CRC) in relatives of patients with colorectal carcinoma in situ (CCIS), which is lacking in the literature. Patients and Methods: We collected data from Swedish family-cancer datasets and calculated standardized incidence ratio (SIR) and cumulative risk of CRC in family histories of CCIS in first- and second-d
Objectives: Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance. Methods: The Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE (<15 month
Fluvial floods can cause significant damages and are expected to increase in magnitude and frequency throughout the twenty-first century due to global warming. Alongside hazard characteristics, damage potentials depend on exposure and vulnerability, which are changing in the wake of socio-economic developments. In the context of continuously evolving damage-causing factors, assessments of future c
Background: Despite standard-of-care androgen-deprivation therapy and an increasing number of treatment options, the mortality rate for prostate cancer remains high. Progress to metastatic castration-resistant prostate cancer (mCRPC) necessitates additional treatments. Abiraterone acetate plus prednisone or prednisolone (AAP) prolongs survival in chemotherapy-naive and docetaxel-experienced patien
Core-shell nanoparticles have gathered much attention of the scientific community owing to their potential applications in various fields including biomedical imaging and catalysis. Predicting core-shell preference1-3 is, however, still largely based on a few experimental observations and limited theorical studies, and hence development of new core-shell nanoparticles is normally built on a trial-
