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Mucosal glucagon-like peptide-1 and gastric inhibitory polypeptide cell numbers in the super-obese human foregut after gastric bypass.

Super-obesity, a body mass index>50 kg/m(2), is difficult to treat. Many studies have focused on the anatomic changes of the intestines; the physiologic background is not clearly identified. It is established that Roux-en-Y gastric bypass (RYGB) augments secretion of glucagon-like peptide-1 (GLP-1), peptide tyrosine tyrosine (PYY), and insulin, but other aspects of gut hormone cell function in the

Molecularly selective nanopatterns using nanoimprint lithography: A label-free sensor architecture

Nanoimprint lithography (NIL) can generate well defined nanostructures with high efficiency and at very low cost. Molecular imprinting (MIP) is a "bottom-up" technique creating a polymer layer exhibiting structures with a molecular selectivity. Such polymer structures may be employed as molecular recognition sites for sensing applications. In this work, the authors combine NIL with MIP and they ar

Nanofluidics in hollow nanowires.

We present a novel scheme for producing nanotube membranes using free-standing hollow nanowires, with easily controllable dimensions. GaAs-AlInP core-shell nanowires were grown by metal-organic vapor phase epitaxy and were partially embedded in a polymer film. The GaAs core and substrate were etched selectively, leaving tubes with open access to both sides of the membrane. Electrophoretic transpor

Branched nanotrees with immobilized acetylcholine esterase for nanobiosensor applications.

A novel lab-on-a-chip nanotree enzyme reactor is demonstrated for the detection of acetylcholine. The reactors are intended for use in the RISFET (regional ion sensitive field effect transistor) nanosensor, and are constructed from gold-tipped branched nanorod structures grown on SiN(x)-covered wafers. Two different reactors are shown: one with simple, one-dimensional nanorods and one with branche

Wideband and Non-Dispersive Wavelet Transmission using Leaky Lens Antenna

An ultra-wideband, non-dispersive leaky lens antenna system for impulse applications has been designed, fabricated and characterized. An in-house wavelet generator is connected to the antenna to transmit 100 ps-long square pulses with center frequencies at 45, 60 and 75 GHz. It is shown that the leaky lens antenna has negligible distortion and preserves the pulse shape generated by the millimeter-

Declining prevalence rates of syphilis among police officers in Guinea-bissau, west Africa, 1990-2010.

We analyzed prevalence rates of syphilis (positive Treponema pallidum hemagglutinin antigen/T. pallidum particle antigen and venereal disease research laboratory test) among police officers in Guinea-Bissau from 1990 to 2010 and found a significant decline from 4.5% to 0.4% (P = 0.0065). Our results are in line with other recent reports from West Africa. More research is needed to identify the rea

Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged

Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular

Study of carrier concentration in single InP nanowires by luminescence and Hall measurements

The free electron carrier concentrations in single InP core-shell nanowires are determined by micro-photoluminescence, cathodoluminescence (CL) and Hall effect measurements. The results from luminescence measurements were obtained by solving the Fermi-Dirac integral, as well as by analyzing the peak full width at half maximum (FWHM). Furthermore, the platform used for Hall effect measurements, com

Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers

Introduction: Current attempts to identify genetic modifiers of BRCA1 and BRCA2 associated risk have focused on a candidate gene approach, based on knowledge of gene functions, or the development of large genome-wide association studies. In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidat

A General Approach for Sharp Crystal Phase Switching in InAs, GaAs, InP, and GaP Nanowires Using Only Group V Flow.

III-V-based nanowires usually exhibit random mixtures of wurtzite (WZ) and zinc blende (ZB) crystal structure, and pure crystal phase wires represent the exception rather than the rule. In this work, the effective group V hydride flow was the only growth parameter which was changed during MOVPE growth to promote transitions from WZ to ZB and from ZB to WZ. Our technique works in the same way for a

'Calibration' of our patch test reading technique is necessary.

Background: Patch testing has been used for more than 100 years as the best means to diagnose contact allergy. The increased use of the technique makes standardization of the methodology most important. Progress in the standardization of the patch test technique has been made through guidelines. Objectives: To investigate the intra-individual and inter-individual differences in reading of patch

Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts

Background: Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players in regulating the homeostasis of ECM proteins. The aim was to study the synthesis of prostacyclin an

Population-based estimates of common comorbidities and cardiovascular disease in ankylosing spondylitis.

OBJECTIVE:: To study the rate of common comorbidities and cardiovascular disease in ankylosing spondylitis (AS) patients compared with the general population seeking health care. METHODS:: This cohort study included 935 subjects (67% men) age ≥20 years, diagnosed with AS and the adult background population in southern Sweden. During 2004 to 2007 we recorded the occurrence of physicians' diagnostic

Self-catalyzed MBE grown GaAs/GaAsxSb1-x core-shell nanowires in ZB and WZ crystal structures

We have investigated the growth of self-catalyzed GaAs/GaAsxSb1-x core-shell nanowires directly on Si(111) substrates by molecular beam epitaxy. The compositions of the GaAsxSb1-x shells are tuned in a wide range where the Sb-content is varied from 10 to similar to 70%, covering the miscibility gap. In addition, the GaAsxSb1-x shells are grown on both zinc blende (ZB) and wurtzite (WZ) crystal str

Former Male Elite Athletes Have Lower Incidence of Fragility Fractures than Expected.

PURPOSE: Physical activity during growth is associated with high peak bone mass and may, as a result, prevent osteoporosis later in life. It is therefore possible that athletic activity during youth could lower the risk of fragility fractures in old age. Though, this is currently unclear and, based on evaluations of surrogate skeletal end point variables in former athletes, we hypothesized that th

Predicting Changes in Cardiovascular Risk Factors in Type 2 Diabetes in the Post-UKPDS Era: Longitudinal Analysis of the Swedish National Diabetes Register.

The aim of the current study was to provide updated time-path equations for risk factors of type-2-diabetes-related cardiovascular complications for application in risk calculators and health economic models. Observational data from the Swedish National Diabetes Register were analysed using Generalized Method of Moments estimation for dynamic panel models (N = 5,043, aged 25-70 years at diagnosis

Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case-control study.

OBJECTIVES: Rheumatoid arthritis (RA) is less common among men than women, and sex hormones have been suggested to play a part in the pathogenesis. Lower levels of testosterone have been demonstrated in men with RA, but it is not known if these changes precede the disease. METHODS: In a nested case-control study, using information and blood samples from a population-based health survey, we identif