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Retinal pericytes play an important role in many diseases of the eye. Immunohistochemical staining techniques of retinal vessels and microvascular pericytes are central to ophthalmological research. It is vital to choose an appropriate method of visualizing the microvascular pericytes. We describe retinal microvascular pericyte immunohistochemical staining in cryo-sections, whole-mounts, and hypot
The Harmonized Parabolic Synthesis methodology is a further development of the Parabolic Synthesis methodology for approximation of unary functions such as trigonometric functions, logarithms and the square root with moderate accuracy for ASIC implementation. These functions are extensively used in computer graphics, communication systems and many other application areas. For these high-speed appl
Background: A standardized evaluation tool is needed for the assessment of surgical outcomes in cleft lip surgery. Current scales for evaluating unilateral cleft lip/nose (UCL/N) aesthetic outcomes are limited in their reliability, ease of use, and application. The Unilateral Cleft Lip Surgical Outcomes Evaluation (UCL SOE) scale measures symmetry of 4 components and sums these for a total score.
Considering climate change and assessing its impacts is challenging due to dealing with large data sets and uncertainties. This paper discusses an approach for the impact assessment of climate change based on synthesizing weather data sets out of several climate scenarios, in a way to generalize the assessment despite of the existence of climate uncertainties. The is based on creating one-year wea
18F-dopa PET measuring aromatic l-amino acid decarboxylase activity is regarded as the gold standard for evaluating dopaminergic function in Parkinson's disease. Radioligands for dopamine transporters are also used in clinical trials and for confirming PD diagnosis. Currently, it is not clear which imaging marker is more reliable for assessing clinical severity and rate of progression. The objecti
The concept of Partially Premixed Combustion (PPC) in internal combustion engines has shown to yield high gross indicated efficiencies, but at the expense of gas exchange efficiencies. Most of the experimental research on partially premixed combustion has been conducted on compression ignition engines designed to operate on diesel fuel and relatively high exhaust temperatures. The partially premix
Background: In recent years, emphasis has been put on that medical student should demonstrate pre-practice/pre-registration core procedural skills to ensure patient safety. Nonetheless, the formal teaching and training of basic suturing skills to medical students have received relatively little attention and there is no standard for what should be tested and how. The aim of this study was to devel
Rapporten avser följa upp och utvärdera de resultat som kom från projektet CONMOD rörande fuktanalyser. I de sju rapporterna som har utgjort underlag för denna undersökning har står det generellt sett väldigt lite om fukt med två undantag. De två rapporter där det står mest om fukt och fuktmodellering, är dels i bilaga A5.4, i rapporten ”Barsebäck NPP- Material testing project”, Materialanalyser a
Physiological adaptation through acclimation is one way to cope with temperature changes. Biochemical studies on acclimation responses in ectotherms have so far mainly investigated consequences of short-term acclimation at the adult stage and focussed on adaptive responses. Here, we assessed the consequences of rearing Drosophila melanogaster at low (12°C), benign (25°C) and high (31°C) temperatur
A major challenge in microbial ecology is linking diversity and function to determine which microbes are actively contributing to processes occurring in situ. Bioorthogonal non-canonical amino acid tagging (BONCAT) is a promising technique for detecting and quantifying translationally active bacteria in the environment. This technique consists of incubating a bacterial sample with an analog of met
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. A characteristic feature of RA is the presence of anti-citrullinated protein antibodies (ACPA). Since ACPAs are highly specific for RA and are often present before the onset of RA symptoms, they have become valuable diagnostic and prognostic. As a result, several assays for detection of ACPAs exist, which vary in sensitivity a
An important part of the justification process is assessment of the radiation risks caused by exposure of a patient during examination. The authors developed official national methodology both for medical doctors and sanitary inspectors called ‘assessmentof radiation risks of patients undergoing diagnostic examinations with the use of ionizing radiation’. The document addressespatients of various
Computed tomography (CT) is a widespread diagnostic modality that is commonly associated with relatively high patient doses. Hence, optimization of radiation protection of the patients from CT examinations is extremely important. An integrant part of radiation protection in medicine is a system of diagnostic reference levels (DRLs). The aim of the study was to evaluate the possibility of establish
Xyloside analogues with substitution of the endocyclic oxygen atom by sulfur or carbon were investigated as substrates for β-1,4-galactosyltransferase 7 (β4GalT7), a key enzyme in the biosynthesis of glycosaminoglycan chains. The analogues with an endocyclic sulfur atom proved to be excellent substrates for β4GalT7, and were galactosylated approximately fifteen times more efficiently than the corr
The most critical question for climate research is no longer about the problem, but about how to facilitate the transformative changes necessary to avoid catastrophic climate-induced change. Addressing this question, however, will require massive upscaling of research that can rapidly enhance learning about transformations. Ten essentials for guiding action-oriented transformation and energy resea
A socially mixed population is a politically stated ambition in Stockholm, the capital of Sweden. By providing a variety of tenure alternatives – i.e. rental and ownership housing – throughout all neighborhoods it is presumed this objective could be at least partially fulfilled. Since current tenure proportions display a weak balance in many neighborhoods it could consequently be assumed that gove
Background: Patients with synchronous colorectal liver metastases (sCRLM) are increasingly operated with liver resection before resection of the primary cancer. The aim of this study was to compare outcomes in patients following the liver-first strategy and the classical strategy (resection of the bowel first) using prospectively registered data from two nationwide registries. Methods: Clinical, p
One year ago, we discovered a new family of insect RYamide neuropeptides, which has the C-terminal consensus sequence FFXXXRYamide, and which is widely occurring in most insects, including the fruitfly Drosophila melanogaster and the red flour beetle Tribolium castaneum (F. Hauser et al., J. Proteome Res. 9 (2010) 5296-5310). Here, we identify a Drosophila G-protein-coupled receptor (GPCR) coded f
