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Cancer-associated fibroblasts (CAF) stimulate tumor growth and metastasis. Signals supporting CAF function are thus emerging as candidate therapeutic targets in the tumor microenvironment. The chemokine CXCL14 is a potent inducer of CAF protumorigenic functions. This study is aimed at learning how the protumoral functions of CXCL14-expressing CAF are maintained. We found that the nitric oxide synt

We consider the effect of signaling rate (baud rate) on the information rate of single carrier linear transmission systems with Gaussian inputs. Several different communication scenarios are investigated: correlated or uncorrelated symbols, a fixed modulation pulse or a modulation pulse varying with the signaling rate and frequency selective or flat channels. For uncorrelated symbols, we show that

This paper presents the 16-element antenna array with parasitic microstrip antenna single element. Antenna designed to operate at 60 GHz and its structure based on low-temperature cofired ceramic (LTCC) substrate. Gain more then 18 dBi and return loss bandwidth about 20% were obtained after antenna geometry parameters optimization

Background: Many patients with cervical disc disease require leave from work, due to long-lasting, complex symptoms, including chronic pain and reduced levels of physical and psychological function. Surgery on a few segmental levels might be expected to resolve disc-specific pain and reduce neurological deficits, but not the non-specific neck pain and the frequent illness. No study has investigate

Background The Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) blocks the Complement fragment C5a receptor (C5aR) and formylated peptide receptor (FPR) and is thereby a potent inhibitor of neutrophil chemotaxis and activation of inflammatory responses. The majority of the healthy human population has antibodies against CHIPS that have been shown to interfere with its function in vit

The European Spallation Source (ESS) linac will consist of three families of superconducting RE cavities to accelerate protons to a final beam energy of 2.5 GeV for collision with the target. Beam induced HOMs in these cavities may drive the beam unstable and increase the cryogenic load, severely limiting the operation of the linac. The effect of these modes on the beam quality is investigated in

This is the first of two papers introducing a novel thermomechanical continuum constitutive model for cemented granular materials. Here, we establish the theoretical foundations of the model, and highlight its novelties. At the limit of no cement, the model is fully consistent with the original Breakage Mechanics model. An essential ingredient of the model is the use of measurable and micro-mechan

The model for permanent deformation in asphalt concrete (AC) layers used in the Mechanistic-Empirical Pavement Design Guide (MEPDG) was evaluated. Two instrumented flexible pavements were subjected to heavy vehicle simulator testing at three constant temperatures. Permanent deformation modelling was carried out using the MEPDG software v1.003 at the highest accuracy level. The nationally calibrate

Pickering emulsions are emulsions that are stabilized by fine particles. They have been the focus of considerable research in the past decade due to their properties such as high stability with respect to coalescence and Ostwald ripening, as well as due to advances in nanotechnology that allows us to create and characterize nano-scale structures in new ways. This work reviews some of the recent wo

The purpose of this report is to develop a model that identifies and reveals the total carbon dioxide emissions generated throughout in- and outbound freight transport made by Höganäs Sweden. The developed model is to be used for future environmental calculations and also act as a tool for discovering new areas of environmental improvements. During the developing process of the model a key issue

Mekoniumfärgat fostervatten (MSAF) förekommer i cirka tio procent av alla förlossningar med risk för uppkomst av mekonium aspiration syndrom (MAS). På grund av ökad morbiditet och mortalitet som associeras med MAS är förebyggande åtgärder av största vikt. Syftet med litteraturstudien var att finna fakta i hurvida rensugning av barnets luftvägar bör utföras vid förekomst av MSAF under en förlossnin