Filetype
Background and AimsMRCP is used for diagnosis and follow-up of patients with primary sclerosing cholangitis (PSC). Interest in the prognostic value of MRCP is increasing. The aim of our study is to develop an MRCP-score based on cholangiographic findings previously associated with outcomes and assess its reproducibility and prognostic value in PSC.MethodsThe score (DiStrict-score) was developed ba
PurposeMagnetization transfer saturation (MTsat) is a useful marker to probe tissue macromolecular content and myelination in the brain. The increased B1+ inhomogeneity at 7T and significantly larger saturation pulse flip angles which are often used for postmortem studies exceed the limits where previous B1+correction methods are applicable. Here, we develop a calibration-based correction model
ObjectivesTo show feasibility of synthetic computed tomography (sCT) images generated using a commerciallyavailable software, enabling MRI-only treatment planning for the brain in a clinical setting.Patients and Methods20 and 16 patients with brain malignancies, including post-surgical cases, were included for validationand treatment, respectively. Dixon MR images of the skull were exported to the
Affibody molecules constitute a class of small (7 kDa) scaffold proteins that can be engineered to have excellent tumor targeting properties. High reabsorption in kidneys complicates development of affibody molecules for radionuclide therapy. In this study, we evaluated the influence of the composition of cysteine-containing C-terminal peptide-based chelators on the biodistribution and renal reten
Engaging students in active participation and collaborative learning is an important pedagogical component of teaching and learning in higher education. Teachers use a variety of activities to engage students, such as interactive lectures, presentations, group activities, and projects. A metaphorical understanding of the teaching-learning process may help in the implementation of innovative and gr
Water molecules play important roles in all biochemical processes. Therefore, it is of key importance to obtain information of the structure, dynamics, and thermodynamics of water molecules around proteins. Numerous computational methods have been suggested with this aim. In this study, we compare the performance of conventional and grand-canonical Monte Carlo (GCMC) molecular dynamics (MD) simula
In search for measures to reduce greenhouse gas emissions from transport, insights into the characteristics of all sorts of trips and specifically trips by car are needed. This paper focuses on everyday leisure trips for social and recreational purposes. Travel behaviour for these purposes is analysed considering individual and household factors as well as properties of the trip, based on Swedish
This work presents a case where a combination of electromagnetics (EM61), refraction seismic surveys and a geotechnical survey allowed a detailed mapping of the near surface at a soil depot.This work presents a case where a combination of electromagnetics (EM61), refraction seismic surveys and a geotechnical survey allowed a detailed mapping of the near surface at a soil depot. Such results together with knowledge of the glacial overburden and groundwater potential enabled accurate determination of digging depth within the area, and thereby optimizing extension of the soil depot. The
Increases in temperature related to global warming have important implications for organismal fitness. For ectotherms inhabiting temperate regions, ‘winter warming’ is likely to be a key source of the thermal variation experienced in future years. Studies focusing on the active season predict largely positive responses to warming in the reptiles; however, overlooking potentially deleterious conseq
This article reports on an investigation of audit independence in the context of local public audit in Sweden. The article focuses on the influence of two different sets of interests. The results show that there is a risk that the way the results of the audit process are communicated and disseminated in an organization is influenced by political, as well as market, interests. The article reveals t
Organisational structures in the transport sector are often complex and fragmented, with different authorities responsible for different stages of a traveller’s journey. In such circumstances, collaboration across organisationalboundaries is required to facilitate intermodal journeys. This paper aims to provide empirically grounded insights into collaboration in transport planning, extending the l
Meteorological drought is a common hydrological hazard that affects human life. It is one of the significant factors leading to water and food scarcity. Early detection of drought events is necessary for sustainable agricultural and water resources management. For the catchments with scarce meteorological observatory stations, the lack of observed data is the main leading cause of unfeasible susta
BACKGROUND: Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH: An expert committee compiled evidence-based recommendations for laboratory analysis in screening, diagnosis, or monitoring of diabetes. The overall quality of the evidence and the strength of t
Flooding is a natural but unavoidable disaster that occurs over time. Flooding threatens human life, property, and resources and affects regional and national economies. Through frequency ratio and MaxEnt modeling, flood sensitivity was determined in the Amu Darya River Basin in Badakhshan Province, Afghanistan. Slope, plan curvature, distance to river, rainfall, aspect, land use, elevation, Norma
This article conceptualizes evolutionary theory as a bridge between existing theorizing in strategic communication on the one hand, the mind sciences on the other. It discusses six core concepts of evolutionary psychology that have a bearing on strategic communication theory: a) the human as a highly flexible social species; b) the regulation of individually-minded vs. collectively-minded behavior
Occupational therapists support and enable people to partake in occupations or activities that are important to them; that they need/want/are expected to do. Occupational therapists are increasingly involved in services addressing the impact that social inequalities can have on peoples’ wellbeing. One way in which occupational therapy students in NUI Galway learn relevant skills is through service
