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Lactoferrin-derived peptide PXL01 impacts nerve regeneration after sciatic nerve reconstruction in healthy and diabetic rats

INTRODUCTION: Although advanced surgical techniques are available, satisfactory functional outcomes after peripheral nerve injuries are uncommon. Hence, immune-modulating factors such as PXL01, a lactoferrin-derived peptide that improves axonal outgrowth in injured human digital nerves, have gained attention. We previously reported a short-term immunosuppressive effect of PXL01 after the repair of

Prospective Assessment of Clinically Relevant Fluid Balance Thresholds Associated With Postoperative Complications in Advanced Ovarian Cancer

Background: Reliable data on optimal fluid management in the perioperative period for patients with advanced ovarian cancer undergoing cytoreductive surgery is limited. These patients often present with malignant ascites and are prone to significant fluid shifts perioperatively. For this reason, our objective was to define clinical targets for optimal fluid balance and determine whether initial as

Mini-review of the EAT-Lancet planetary health diet and its role in cardiometabolic disease prevention

Human diets play a crucial role in both human health and environmental sustainability. In 2019, the EAT-Lancet Commission on healthy diets from sustainable food systems introduced the EAT-Lancet planetary health diet, a universal reference diet designed to promote human health while minimizing environmental degradation. It is a predominantly plant-based dietary pattern, rich in whole grains, veget

Protection Against Pneumonia Induced by Vaccination with Fimbriae Subunits from Klebsiella pneumoniae

Background: Klebsiella pneumoniae infections pose a great burden worldwide, causing high morbidity and mortality, which are worsened by the increase in multidrug-resistant strains. New therapeutic/prophylactic strategies are urgently needed to overcome antibiotic resistance and reduce the health and economic impacts of diseases caused by this pathogen. Fimbriae are important virulence factors invo

Solution and Interfacial Properties of Cyclic Containing Anionic Surfactants

The bulk micellar and surface adsorption behaviour of a bio-derived cyclic-containing anionic surfactant, sodium tetradecyl furan sulfonate (STFS), has been studied in this work. To determine its viability as an alternative to petrochemically derived surfactants in detergents, the self-assembly andadsorption properties were measured both alone and in binary and ternary mixtures with a common anion

Prognostic performance of preoperative cardiac troponin and perioperative changes in cardiac troponin for the prediction of major adverse cardiac events and mortality in noncardiac surgery : A systematic review and meta-analysis

Background Increased postoperative cardiac troponin (cTn) independently predicts short-term mortality. Previous studies suggest that preoperative cTn also predicts major adverse cardiovascular events (MACE) and mortality after noncardiac surgery. The value of preoperative and perioperative changes in cTn as a prognostic tool for adverse outcomes has been sparsely investigated. Methods and findings

Internationellt tvingande regler - ett stort frågetecken i svensk arbetsrätt

I ett samhälle med ökad globalisering blir regler angående den internationella privat- och processrätten allt viktigare. Denna uppsats behandlar lagvalsregler, vilka går att finna i Romkonventionen. Romkonventionens huvudregel är lagvalsfrihet. Det finns dock bestämmelser i konventionen som inskränker denna möjlighet. Artikel 7 rörande internationellt tvingande regler är ett exempel på detta och ä

Exhaustion Doctrine: Close to the Ultimate Aim of Copyright

The exhaustion doctrine (also known in some jurisdictions as the ''first sale doctrine See U.S. Copyright Code Section 109(a)'') is one of the basic rules of intellectual property (IP) system, and is applied to many IP rights, from copyright to trademark. The term ''exhaustion'' or ''first sale'' describes the concept of this rule, where, after the &

Brandteknisk riskvärdering, Holmagården Svedala

This report contains a description of the fire safety situation of Holmagården, which is a residence for elderly with special needs, in Svedala, Sweden. The purpose is to evaluate the personal safety in case of fire where concern has taken to the health status of the individuals at Holmagården. Three different fire scenarios have been the starting direction for modelling and calculating. To estima

Polymer gel dosimetry - Using MRI-readout, simplified relatively non-toxic mixing procedure tested on FLASH

Background: One of the polymer gel dosimeters available today is the N-isopropylamide (NIPAM) polymer gel dosimeter which has a less toxic monomer compared to other polymer gels and the advantage of being able to be manufactured under normal oxygen levels. Polymer gel dosimeters in general are advantageous independent dosimeters to use for verification of new radiation treatment techniques due to

'It makes things up like crazy!' : Swedish school librarians' perceptions on ChatGPT

The aim of my thesis is to provide research-based insight into AI technologies for information seeking’s place in future school library operations. To achieve this aim, I am looking at Swedish school librarians’ perceptions and views on AI technologies for information seeking, especially in connection with their work on media and information literacy. My research questions are as follows: (Q1) How

Bristande delaktighet, information och respekt: en explorativ studie om patienters upplevda autonomi inom vuxenpsykiatrin

Autonomins roll i vården är svårbegriplig och varken patient eller vårdgivare har en tydlig uppfattning av begreppet. Detta resulterar i att patienters rättigheter regelbundet överträds vilket förhindrar tillfrisknandet och riskerar att vidare skada patienter. Syftet med denna explorativa studie var att undersöka och analysera anmälares (patienter och anhöriga) upplevelser av kränkningar inom den The role of autonomy in healthcare is unclear, and neither patients nor healthcare providers have a clear understanding of the concept. This results inpatients' rights being violated regularly, which hinders recovery and risks further harming patients. The purpose of this exploratory study was to investigate and analyze the reporters’ (patients and relatives) experiences of violations within t

EMBRACE – A modular chair

This Bachelor’s degree project investigates how to create a modular chair system. It should let the consumer combine different parts to create a chair that fits their home, style and needs. The focus is on how a low number of parts can be used in different ways to create differentcombinations. It should also be easy to replace and recycle all parts when needed. This document shows the full design

A short delay from out of hospital cardiac arrest to call for ambulance increases survival

Aim To describe the relative impact on survival of the delay from estimated time of collapse to call for an ambulance among patients who suffer from a bystander witnessed out of hospital cardiac arrest of a cardiac aetiology. Methods A majority of all ambulance organizations in Sweden (covering 85% of Sweden inhabitants) participate in a National survey of out of hospital cardiac arrest. Results I

Ska generna styra vad vi äter?

This article gives an overview of some ethical problems raised in connection to nutritional genomics, especially the use of knowledge from nutrigenomics as a basis for personalised nutrition after a genetic test.

Risk of hospitalization for type 2 diabetes in first- and second-generation immigrants in Sweden: a nationwide follow-up study.

OBJECTIVES: This is the first nationwide study with the aim to analyze whether there is an association between country of birth in first-generation immigrants and hospitalization for type 2 diabetes (T2D), and to study whether any such association remains in second-generation immigrants. DESIGN: In this follow-up study, the Swedish Hospital Discharge Register was used to identify all hospital

Design of a high-density multi-channel electrode for multi-structure parallel recordings in rodents

In neurophysiology, investigating brain connectivity within and between different brain structures is of fundamental importance for understanding nervous system function and its relation to behavior. Yet, parallel recordings in multiple brain structures is highly challenging, especially in rodents, which are most commonly employed in neurophysiological research but rather small in size. In this st

A Swedish Population-Based Multivariate Twin Study of Externalizing Disorders.

In epidemiological and twin populations, prior interview studies have identified an externalizing spectrum of disorders. Could this be detected utilizing objective registry data? In 20,603 twin pairs from the Swedish Twin Registry, we obtained information from national medical, criminal and pharmacy records on drug abuse (DA), criminal behavior (CB) and alcohol use disorders (AUD). Multivariate tw