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Background: The 2017 Alzheimer’s disease (AD) Strategic Biomarker Roadmap (SBR) structured the validation of AD diagnostic biomarkers into 5 phases, systematically assessing analytical validity (Phases 1–2), clinical validity (Phases 3–4), and clinical utility (Phase 5) through primary and secondary Aims. This framework allows to map knowledge gaps and research priorities, accelerating the route t
Background: To reduce local recurrence risk, rectal washout (RW) is integrated in the total mesorectal excision (TME) technique when performing anterior resection (AR) for rectal cancer. Although RW is considered a safe practice, data on the complication risk are scarce. Our aim was to examine the association between RW and 30-day postoperative complications after AR for rectal cancer. Methods: Pa
Pepsin-like aspartic proteases (PAPs) are a class of aspartic proteases which shares tremendous structural similarity with human pepsin. One of the key structural features of PAPs is the presence of a β-hairpin motif otherwise known as flap. The biological function of the PAPs is highly dependent on the conformational dynamics of the flap region. In apo PAPs, the conformational dynamics of the fla
One can falsely assume that it is well known that bacteremia is associated with higher mortality in sepsis. Only a handful of studies specifically focus on the comparison of culture-negative and culture-positive sepsis with different conclusions depending on study design. The aim of this study was to describe outcome for critically ill patients with either culture-positive or -negative sepsis in a
We analyze the problem of allocating indivisible objects and monetary compensations to a set of agents. In particular, we consider envy-free and budget-balanced rules that are least manipulable with respect to agents counting or with respect to utility gains. A key observation is that, for any profile of quasi-linear preferences, the outcome of any such least manipulable envy-free rule can be obta
Städer, och framför allt stadsdelar, är nyckelplatser för att tillhandahålla en uppbyggd miljö med direkta kopplingar till sociala och miljömässiga frågor. De ses i allt högre grad som platser för strategiska åtgärder i en omställning till hållbarhet och resiliens, med stora möjligheter till grundläggande samhällsförändringar. Inramningen (så kallad framing) på stadsdelsnivå av problem och lösning
Background: Occupational therapists are an essential healthcare profession and play a vital role in rehabilitating patients in the activities of daily life. Nevertheless, many occupational therapists in Sweden are leaving the profession and this jeopardises occupational therapy services. Objective: To explore factors that cause occupational therapists to seriously consider leaving their profession
Existing criteria for inclusion in the European baseline series are summarized. Additional criteria are developed to aid decision making where the current criteria do not yield an unequivocal result. These include a consideration of whether an allergen (hapten) is better placed in a special series and the frequency with which an allergen cross-reacts with existing markers in the baseline series.
Industrial cyber-physical system products interleave hardware, software, and communication components. System complexity is increasing simultaneously with increased demands on quality and shortened time-to-market. To effectively support the development of such systems, we present languages and tools for comprehensive integrated model-based development that cover major phases such as requirement an
Ghost quantitative trait loci (QTL) are the false discoveries in QTL mapping, that arise due to the "accumulation" of the polygenic effects, uniformly distributed over the genome. The locations on the chromosome that are strongly correlated with the total of the polygenic effects depend on a specific sample correlation structure determined by the genotypes at all loci. The problem is particularly
Fires in road tunnels constitute complex scenarios with interactions between the fire, tunnel users and safety measures. More and more methodologies for risk analysis quantify the consequences of these scenarios with complex models. Examples for complex models are the computational fluid dynamics model Fire Dynamics Simulator (FDS) and the microscopic evacuation model FDS+Evac. However, the high c
The European steel industry must achieve deep greenhouse gas emission reductions to become climate neutral by 2050. New business models are often proposed as one of the key solutions but are mostly addressed in general terms, without elaborating on or systematically analyzing how these new business models are actually linked to specific mitigation measures or strategies. In this paper, we assess w
Vad är ett landskapsperspektiv? Jordbrukslandskap är multifunktionella – det vill säga att de bidrar direkt och indirekt med många olika värden. De är helt avgörande för produktionen av livsmedel och för lantbrukarens inkomster, men genererar också andra värden som inte alltid är lika synliga.
With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a need for diagnostic tests has surfaced. Point-of-care (POC) antibody tests can detect immunoglobulin (Ig) G and M against SARS-CoV-2 in serum, plasma, or whole blood and give results within 15 min. Validation of the performance of such tests is needed if they are to be used in clinical practice. In this study, we
Submerged aquatic vegetation (SAV) is one of the main producers in inland lakes. Tracking the temporal and spatial changes in SAV is crucial for the identification of state changes in lacustrine ecosystems, such as changes in light, nutrients, and temperature. However, the available SAV classification algorithms based on remote sensing are highly dependent on field survey data and/or human interve
The demand for large-scale and long-term information on tree growth is increasing rapidly as environmental change research strives to quantify and forecast the impacts of continued warming on forest ecosystems. This demand, combined with the now quasi-global availability of tree-ring observations, has inspired researchers to compile large tree-ring networks to address continental or even global-sc
