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For more than a century the research on the Antikythera Mechanism engaged scientists from a widerange of scientific disciplines searching for clues, in order to solve the mystery that this unique ar-chaeological find poses. The results so far have been spectacular enough to re-write the History ofTechnology providing new aspects on the degree of technological sophistication and scientific de-velop
The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases. They are downstream effectors of the Ras/ERK/MAPK signaling cascade. ERK1/2 activation directly results in the phosphorylation of RSKs, which further, through interaction with a variety of different downstream substrates, activate various signaling events. In this context, they have been shown t
In order to rationally design polymer vehicles for controlled drug delivery it is important to completely understand the nature and mechanisms of the structural evolution of the polymer matrix that ultimately controls drug release kinetics. NMR cryoporometry has been used previously to study drug release from polymer vehicles. However, no previous studies have employed the integrated cryoporometry
A strategy for the formation of thin reconstituted cellulose films (pure or modified)) with embedded receptors or embedded ion-selective components is reported. Cellulose nanofibril ribbons from sisal of typically 3-5 nm diameter and 250 nm length are reconstituted into thin films of typically 1.5-2.0 μm thickness (or into thicker free-standing films). Cellulose and cellulose nanocomposite films a
Using a model disordered mesoporous solid with a spatial arrangement of pore sizes analogous to a macroscopic 'ink-bottle', it has been shown that the hysteresis observed in NMR cryoporometry can be deconvoluted into separate single pore and pore-blocking contributions. The suggestion of pore-blocking effects has been confirmed using PFG NMR. Hence, percolation theory has been used, for the first
Denna rapport är en sammanställning och analys av kunskapsläget när det gäller ekosystembaserade metoder för att minska utsläpp och öka upptag av koldioxid hos brukade marker i Skåne. Med fokus på markanvändning och skötselstrategier inom jordbruk och skogsbruk, samt användning av biokol, analyseras och bedöms potentialen för att inom Skånes gränser öka upptag respektive minska utsläpp av kol från
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of caffeine compared to aminophylline or theophylline in preterm infants at risk of apnea, with apnea, or in the peri-extubation phase.
BackgroundThe modified Telephone Interview for Cognitive Status (TICS-M) is a widely used tool for assessing global cognitive functions and screening for cognitive impairments. The tool was conceptualised to capture various cognitive domains, but the validity of such domains has not been investigated against comprehensive neuropsychological assessments tools. Therefore, this study aimed to explore
Background and purposeDeep inspiration breath hold (DIBH) increases lung volume and can potentially reduce treatment-related toxicity in locally advanced lung cancer. We estimated geometric uncertainties in visually guided voluntary DIBH and derived the appropriate treatment margins for different image-guidance strategies.Material and methodsSeventeen patients were included prospectively. An optic
Background: Primary graft failure (PGF) remains the most common cause of short-term mortality after heart transplantation. The main objective was to develop and validate a risk model for prediction of short-term mortality due to PGF after heart transplantation using the ISHLT Heart Transplant Registry. Methods: We developed a non-linear artificial neural networks (ANN) model to evaluate the associ
A 61-year-old male patient presented with rest pain and ulceration in his left leg 1 week after a hybrid procedure with bilateral external iliac stenting, common femoral artery thromboendarterectomy, and left-sided femoral popliteal bypass with an in situ saphenous vein. The bypass had been stented intraoperatively but had again become occluded directly after surgery. In the present report, we dem
In the purple phototrophic bacterium Rhodobacter sphaeroides, light harvesting LH2 complexes transfer absorbed solar energy to RC-LH1-PufX core complexes, which are mainly found in the dimeric state. Many other purple phototrophs have monomeric core complexes and the basis for requiring dimeric cores is not fully established, so we analysed strains of Rba. sphaeroides that contain either native di
Treatment of chronic osteomyelitis by radical debridement and filling of the dead space with antibiotic containing calcium sulphate/hydroxyapatite (CaS/HA) bone substitute has shown excellent long-term outcomes. However, in extensive infections, sessile bacteria may remain in bone cells or soft tissues protected by biofilm leading to recurrences. The primary aim of this study was to evaluate if sy
