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There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal f
Objective: To systematically review the efficacy of psychological, pharmacological, and combined treatments for binge eating disorder (BED). Method: Systematic search and meta-analysis. Results: We found 45 unique studies with low/medium risk of bias, and moderate support for the efficacy of cognitive behavior therapy (CBT) and CBT guided selfhelp (with moderate quality of evidence), and modest su
By utilizing the promising alternative fuel of syngas, and the syngas/diesel dual-fuel reactivity controlled compression ignition (RCCI) is a potential combustion strategy for internal combustion engines. However, the optimal operating parameters for syngas/diesel RCCI engines under wide operating conditions have not been investigated. In this study, the operating parameters include fuel supply, s
During a meeting held in Trento, Italy in March 2017, and organised by the COST Action CHIP ME (IS1303) to discuss about ELSI of genome-editing, many different positions emerged on the possibility to intervene on reproduction and especially on the human embryo. At the time, the Nuffield Council on Bioethics had commissioned a background paper on genome editing, and the corresponding Working Group
In linguistics and in the philosophy of language it is standardly assumed that know is a factive verb, meaning that a sentence such as X knows that p, when uttered in its positive declarative form, presupposes, in fact entails, the truth of its complement. A problem for this analysis is the fact that the verb know can be used non-factively in contexts where it is evident that the proposition expre
Based on multi-link synchronous propagation measurements, we study the downlink performance of Coordinated Multi-point (CoMP) systems. The propagation measurements took place in an outdoor micro-cellular environment with two base stations (BSs) located 60 m apart, each equipped with two cross-polarized co-located antennas. We focus on the challenging case of having closely-located users with 0.5 m
Development of antibody drugs against novel targets and pathways offers great opportunities to improve current cancer treatment. We here describe a phenotypic discovery platform enabling efficient identification of therapeutic antibody-target combinations. The platform utilizes primary patient cells throughout the discovery process and includes methods for differential phage display cell panning,
Antalet cirkulationsplatser fortsätter att öka. Personer med synskada uppger att det är svårt för dem att korsa gatan vid cirkulationsplatser och det finns idag inte tillräckligt med kunskap för att lösa tillgänglighetsproblemen. Den forskning som finns idag studerar enbart blinda personer, trots att den stora majoriteten synskadade har synrester. Syftet med denna studie vAntalet cirkulationsplatser fortsätter att öka. Personer med synskada uppger att det är svårt för dem att korsa gatan vid cirkulationsplatser och det finns idag inte tillräckligt med kunskap för att lösa tillgänglighetsproblemen. Den forskning som finns idag studerar enbart blinda personer, trots att den stora majoriteten synskadade har synrester. Syftet med denna studie var att fastställa hur cir
This paper critically investigates the impact and meaning of managerialism in a pharmaceutical firm by exploring its shaky basis. Managers' explanations of the failure in research leading to new products showed considerable variety. This reflects the absence of any shared understanding of research inefficiencies and difficulties to determine the roots of the problems. Despite this people blame bad
PURPOSE. To determine the proportion of male patients presenting simplex retinal degenerative disease (RD: retinitis pigmentosa [RP] or cone/cone-rod dystrophy [COD/CORD]) with mutations in the X-linked retinal degeneration genes RPGR and RP2. METHODS. Simplex males were defined as patients with no known affected family members. Patients were excluded if they had a family history of parental consa
Alzheimer's Disease (AD) is the most prevalent form of dementia worldwide, yet the development of therapeutics has been hampered by the absence of suitable biomarkers to diagnose the disease in its early stages prior to the formation of amyloid plaques and the occurrence of irreversible neuronal damage. Since oligomeric A beta species have been implicated in the pathophysiology of AD, we reasoned
A key to successful chronic neural interfacing is to achieve minimal glial scarring surrounding the implants, as the astrocytes and microglia may functionally insulate the interface. A possible explanation for the development of these reactions is mechanical forces arising between the implants and the brain. Here, we show that the difference between the density of neural probes and that of the tis
In this paper we demonstrate how surface site specific experimental information can be obtained from free low nanometer scale clusters using photoelectron spectroscopy utilising synchrotron radiation. In addition, we show how it can be used to gain insight into the geometry and surface structure of the clusters. The present experiments were conducted on alkali metal halides, RbCl and CsCl, which w
Objectives: We evaluated a method for gas monitoring in the mastoid cavity using tunable diode laser spectroscopy by comparing it to simultaneously obtained computed tomographic (CT) scans. Methods: The presented optical technique measures free gases, oxygen (O2), and water vapor (H2O) within human tissue by use of low-power diode lasers. Laser light was sent into the tip of the mastoid process
