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OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of immunosuppressants with or without corticosteroids compared to corticosteroid monotherapy for the treatment of IgG4-related disease in people 18 years or older.

Leucine-rich repeat containing 15 (LRRC15) has emerged as an attractive biomarker and target for cancer therapy. Transforming growth factor-β (TGFβ) induces the expression of this plasma membrane protein specifically in aggressive and treatment resistant tumor cells derived from mesenchymal stem cells, with minimal expression observed in non-neoplastic tissues. We have developed a humanized monocl

INTRODUCTION: Maternal blood pressure (BP) is crucial for the health of both mother and fetus, with long-term implications for the child's health. Studies exploring the link between perfluoroalkyl substances (PFAS) exposure and hypertensive disorders of pregnancy often yield inconsistent results, frequently focusing on a single BP measurement rather than longitudinal measurements. This study chara

Empiric combination antibiotic therapy (ECAT) is commonly used to treat healthcare-associated bloodstream infections (HA-BSIs) and sepsis. However, the level of supporting evidence is low and clinical practice varies significantly. We conducted a post hoc analysis using the EUROBACT-2 international cohort study database, which contained data on 2406 adult patients from 328 intensive care units (IC

Each spring, billions of Bogong moths escape hot conditions across southeast Australia by migrating up to 1,000 km to a place that they have never previously visited—a limited number of cool caves in the Australian Alps, historically used for aestivating over summer1,2. At the beginning of autumn, the same individuals make a return migration to their breeding grounds to reproduce and die. Here we

Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN

We simulate hadrons impinging on a homogeneous lead tungstate ((Formula presented.)) calorimeter using GEANT4 software to investigate how the resulting light yield and its temporal structure, as detected by an array of light-sensitive sensors, can be processed by a neuromorphic computing system. Our model encodes temporal photon distributions as spike trains and employs a fully connected spiking n

Background & aims: Alcohol consumption has been inversely associated with type 2 diabetes (T2D), but its influence on autoimmune diabetes is unclear. We investigated the risk of latent autoimmune diabetes in adults (LADA) and T2D in relation to alcohol intake and assessed if potential associations were modified by genetic susceptibility to diabetes. Methods: We used data from a case–control st

Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At national funding level, endocrine societies report limited or little attention of national res

Young adults presenting with knee pain, instability, or both after twisting the knee during sports or at work are commonly seen in primary care. If the symptoms and injury history correspond with suspicion of a torn anterior cruciate ligament (ACL) or meniscal injury, sometimes in combination with positive findings on magnetic resonance imaging, patients are often referred for surgical treatment.

Understanding three Dimensional (3D) fundamental processes is crucial for academic and industrial applications. Nowadays, X-ray time-resolved tomography, or tomoscopy, is a leading technique for in situ and operando 4D (3D+time) characterization. Despite its ability to achieve 1000 tomograms per second at large-scale X-ray facilities, its applicability is limited by the centrifugal forces exerted

https://www.saco.se/globalassets/lokala-akademikerforeningar/privat/siemens-energy-ab/nyhetsbrev/asi-nyhetsbrev-0523.pdf - 2026-05-31

NYTT FRÅN SACO-S SLU Innehåll: • Vårhälsning • Information • Löneenkät • Lönerevision • Digitalt medlemsmöte • Årsmöte • Webbinarier • SACO-S SLU styrelse Vårhälsning Våren är på ingång, det känns framför allt på att ljuset och att en del flyttfåglar är tillbaka. Och då är det dags för Saco-S första nyhetsbrev för året. Det är mycket aktivitet för oss i Saco-styrelsen. Utöver löpande frågor och fö

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/slu/nyhetsbrev/nyhetsbrev_2025-1.pdf - 2026-05-31

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/umea-universitet/dokument/saco-s-radets_stadgar_2010-10-29.pdf - 2026-05-31

Recent high-visibility disasters have fueled public and political awareness of the importance of managing and mitigating their consequences effectively. In response, various countries have enacted legislation that demands the evaluation of emergency responses so that lessons for improvement can be learned. A series of field and experimental studies were conducted from 2005 to 2007 to assess the ab

OBJECTIVETo study the association between dietary flavonoid and lignan intakes, and the risk of development of type 2 diabetes among European populations.RESEARCH DESIGN AND METHODSThe European Prospective Investigation into Cancer and Nutrition-InterAct case-cohort study included 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 participants from among 340,234 participant

Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction. About 20-30 % of cases are inherited in a dominant manner. Mutations in the microtubule-associated protein tau gene (MAPT) cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17T). Here w

Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these foo