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Identification of a novel gene associated with group B Streptococcus persister cell formation and biofilm production

Antibiotic persistence arises when a subset of cells in an otherwise susceptible bacterial population temporarily exhibits elevated tolerance to bactericidal antibiotics. While significant progress has been made in elucidating persister mechanisms, much of this research has focused on Gram-negative bacteria, and these findings are not always applicable to Gram-positive species. This study explores

Ectopic pregnancies : laparoscopic versus vNOTES approach. Surgical and obstetric outcomes

Introduction: Extrauterine pregnancy (EP), represents a significant challenge in reproductive medicine, manifesting in approximately 2% of all pregnancies, primarily implanting within the fallopian tubes (95%). Surgery remains a cornerstone in the therapeutic options for ectopic pregnancies. The most common surgical approach at the moment is laparoscopy. However a relatively new surgical technique

Impact of Acceleration Voltage on Cathodoluminescence for Defect Identification in InGaN Quantum Wells

Micro-LEDs have emerged as a hot research topic due to their potential for next-generation display and lighting applications, necessitating advanced characterization techniques to optimize their performance. This study demonstrates the advantage of cathodoluminescence in the scanning electron microscope to be a critical tool for the optical characterization of InGaN platelets with red quantum well

Exposure to ambient air pollution during pregnancy and risk of early-onset breast cancer

Background: Air pollution has been linked to breast cancer risk, but previous studies have seldom considered specific exposure windows, like pregnancy. During pregnancy the breast undergoes substantial changes and exposures may have a stronger impact than if they occurred during other time periods. This study aims to identify associations between ambient air pollution exposure during pregnancy and

Majorana sweet spots in three-site Kitaev chains

Minimal Kitaev chains, composed of two quantum dots connected via a superconductor, have emerged as an attractive platform to realize Majorana bound states (MBSs). These excitations exist when the ground state is degenerate. The additional requirement of isolating the MBS wave functions further restricts the parameter space to discrete sweet spots. While scaling up to Kitaev chains with more than

Measuring coherence factors of states in superconductors through local current

The coherence factors of quasiparticles in a superconductor determine their properties, including transport as well as their susceptibility to electric fields. In this work, we propose a way to infer the local coherence factors using local transport to normal leads. Our method is based on measuring the local current through a lead as the coupling to a second one is varied; the shape of the current

Complex genotype-phenotype relationships shape the response to treatment of down syndrome childhood acute lymphoblastic leukaemia

Extensive genetic and epigenetic variegation has been demonstrated in many malignancies. Importantly, their interplay has the potential to contribute to disease progression and treatment resistance. To shed light on the complex relationships between these different sources of intra-tumour heterogeneity, we explored their relative contributions to the evolutionary dynamics of Acute Lymphoblastic Le

Using In Situ TEM to Understand the Surfaces of Electrocatalysts at Reaction Conditions: Single-Atoms to Nanoparticles

Catalytic activity is improved by reducing particle size, followed by atomic scale structural and chemical design, allowing physical and electronic confinement of chemical conversion centers. These concepts culminate in single-atom catalysts (SACs) where active precious metal atoms are isolated and anchored on the surface of supports and thus fully utilized for chemical conversion. In contrast, me

Exploring Lignin Conformation in Organic and Deep Eutectic Solvents Using Small-Angle Neutron Scattering

Lignin, a structurally intricate and heterogeneous phenolic biopolymer, holds considerable promise as a sustainable alternative to petrochemical-derived materials across diverse applications in the energy and materials sectors. However, precise lignin molecular weight and structure determination remains challenging due to its intrinsic tendency to aggregate in solution and the absence of chem

Influence of Block Microstructure on the Interaction of Styrene-Maleic Acid Copolymer Aggregates and Lipid Nanodiscs

Investigation of the properties of membrane proteins (MPs) is essential to the successful development of medicines and biotechnology. However, their study is often complicated by denaturation caused by the use of detergents during conventional extraction methods. Copolymers of styrene and maleic acid (SMA) have shown promise in extracting MPs directly from cells while reconstituting lipid memb

Factors associated with health-related quality of life 1 year after COVID-19: a cross-sectional study in Sweden

Aims: The main aim of the present study was to identify factors influencing health-related quality of life (HRQoL), as measured by EQ-5D-5L, in individuals 1 year after the acute phase of COVID-19.Methods: This cross-sectional study included 75 participants (51% females), 1 year after confirmed SARS-CoV-2 infection (76% hospitalised). Associations between HRQoL, measured by patient-reported outcom

Who cares for urban repair? Stretching the life of buildings, the case of the Edman Pavillion in Lund’s (Sweden) People’s Park.

In architecture and urban geography, discussions on repair, maintenance and adap5ve re-usehave emerged as a crucial intellectual terrain. Temporal aspects of how the urban fabric isused have also emerged as an issue worth theore5cal and empirical a=en5on. Latching ontothese themes, we will present work tracking the history of conten5on around the publiclyowned mee5ng and arts venue in Lund’s Peopl

Immunotherapy for Atherosclerosis

Cardiovascular disease is the global number one causeof mortality and morbidity. The majority of cardio vascular diseases are caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The disease is characterized by the formation of atherosclerotic plaques throughout the arterial tree. Over the years, insights intohe pathogenesis of atherosclerosis ha

Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population : the Swedish CArdioPulmonary BioImage Study

Background: Nocturnal gastro-oesophageal reflux (nGER) is common in people with respiratory diseases, but its association with pulmonary abnormalities is not known. Aim: Investigate the association between nGER and pulmonary abnormalities on chest CT in an adult general population. Methods: In total, 28 846 individuals from the general population aged 50-64 years completed questionnaires and under

Families of isospectral and isoscattering quantum graphs

A concept of germ graphs and the M-function formalism are employed to construct large families of isospectral and isoscattering graphs. This approach represents a complete departure from the original approach pioneered by Sunada, where isospectral graphs are obtained as quotients of a certain large symmetric graph. Using the M-function formalism and the symmetries of the graph itself we construct

Advancing Precision Oncology Using Data-Driven Machine Learning Approaches

Precision oncology is being transformed by the integration of advanced machine learning (ML) methods and extensive biomedical data from genomics, imaging, proteomics, and clinical records. ML techniques, including supervised, unsupervised, deep learning, and reinforcement learning, have progressed from experimental tools to robust systems that identify clinically actionable biomarkers, refine prog

Air Pollution and Dementia : Evidence from Epidemiological Studies

This chapter reviews the growing body of epidemiological evidence linking long-term exposure to ambient air pollution with increased risk of dementia, including Alzheimer’s disease (AD) and vascular dementia (VaD). With air pollution now recognized as a potentially modifiable risk factor, the chapter explores mechanistic pathways, such as neuroinflammation and oxidative stress, through which pollu

Effects of Basic Body Awareness Therapy on movement quality in autistic young adults : a superiority pragmatic randomized controlled trial

Introduction Autistic persons experience problems with movements and body awareness in everyday functionality, expressed in affected movement quality. Yet, there is a knowledge gap about the effects of interventions targeting these aspects in autistic persons. Objective To evaluate effects of Basic Body Awareness Therapy (BBAT) and treatment-as-usual (TAU), compared to TAU alone on movement qualit