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Hållbar utveckling, strategier på program- och kursnivå

Efter HSVs utvärdering av CI- utbildningarna fick högskolorna ett tydligt uppdrag att vid uppföljningen redovisa hur hållbar utveckling kommer in i utbildningarna. I planeringsförutsättningarna för de 5-åriga civilingenjörsutbildningarna vid LTH finns kravet på examination av minst 6 hp inom området.

CFD Investigation of Swirl-stabilized Flexi-fuel Burner Using Methane-air Mixture for Gas Turbines

Combustion modeling based on a multi-step global reaction mechanism [1] is applied to CFD (Computational Fluid Dynamics) analysis of a scaled swirl-stabilized 4th generation premixed DLE (Dry Low Emission) burner for gas turbines. The flexi-fuel burner consists of a MAIN premixed flame, a premixed PILOT flame and a confined RPL (Rich Pilot Lean) flame. Both steady-state RANS (Reynolds Averaged Nav

Uromodulin gene variant is associated with type 2 diabetic nephropathy.

AIMS/HYPOTHESIS: About 35% of individuals with type 2 diabetes develop persistent albuminuria, lose renal function, and are at increased risk for microvascular complications like diabetic nephropathy. Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney dis

Identification of Candidate Gene Regions in the Rat by Co-Localization of QTLs for Bone Density, Size, Structure and Strength.

Susceptibility to osteoporotic fracture is influenced by genetic factors that can be dissected by whole-genome linkage analysis in experimental animal crosses. The aim of this study was to characterize quantitative trait loci (QTLs) for biomechanical and two-dimensional dual-energy X-ray absorptiometry (DXA) phenotypes in reciprocal F2 crosses between diabetic GK and normo-glycemic F344 rat strain

Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells

The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias. Co-expression of WT1 and the fusion protein AML1-ETO in mice rapidly induces acute myeloid leukaemia (AML). Mechanisms behind expression of WT1, as well as consequences thereof, are still unclear. Here, we report that the fusion protein BCR/ABL1 increases expression of WT1 mRNA and protein via the phosphatidylinositol-3

Doppler Audio Signal Analysis as an Additional Tool in Evaluation of Umbilical Artery Circulation

Purpose: To investigate the predictive capacity of a new method for sound spectrum analysis of Doppler signals recorded from the umbilical artery in high-risk pregnancies. Material and Methods: The retrospective study comprised 127 pregnant women with various pregnancy complications between 23 and 39 gestational weeks. Umbilical artery blood flow velocity waveforms were recorded with Doppler ultra

Expression of FK506 binding protein 65 (FKBP65) is decreased in epithelial ovarian cancer cells compared to benign tumor cells and to ovarian epithelium.

FK506 binding protein 65 (FKBP65) belongs to a group of proteins termed immunophilins that have a high binding affinity to immunosuppressant drugs as FK506 (tacrolimus) and rapamycin (sirolimus). Treatment of female premenopausal women with tacrolimus, which binds to FKBP65, has been reported to be followed by a strongly increased risk of ovarian cysts. We performed the present study to reveal how

The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study.

Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomarkers of iron metabolism. We investigate associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to cla

Strategic Voting under Coalition Governments

När en väljare röstar med andras beteende i åtanke och politikutfall i sikte är det en "strategisk" röst. Den här studien relaterar väljares strategiska överväganden till olika steg i regeringsbildningsprocessen: att ta plats i parlamentet, ingå i regering, och påverka politikutfallet. Detta innebär att väljaren ibland tänker som ett parti på vad rösten kan få för konsekvenser. Utifrån detta perspIf a voter defects from preference under the consideration of policy outcomes and others' behavior, it is a "strategic vote". This thesis relates voters' strategic considerations to the government formation process: the chances for a party to gain seats, enter office, and affect overall policies. This implies that voters sometimes think like parties on the governmental consequences of the vote. Fr

A new tool for predicting the probability of chronic kidney disease from a specific value of estimated GFR.

Abstract Objective. To demonstrate how patients' probability of having chronic kidney disease (CKD) stage 3-5 (measured GFR <60 mL/min/1.73 m(2)) can be predicted from a specific value of estimated glomerular filtration rate (eGFR). Material and methods. The probability of CKD stage 3-5 was predicted from a logistic regression model (n = 850) using three different eGFR prediction equations: Lund-M

Intraventricular Extension of Supratentorial Intracerebral Hemorrhage: The Modified Graeb Scale Improves Outcome Prediction in Lund Stroke Register.

The modified Graeb Scale (mGS) is a semi-quantitative method to assess the extension of intraventricular hemorrhage (IVH) in patients with intracerebral hemorrhage (ICH). The mGS has been shown to prognosticate outcome after ICH in cohorts derived from convenience samples. We evaluated the external validity of mGS in supratentorial ICH-patients from an unselected cohort.