Search results

Isolated attosecond pulse (IAP) generation usually involves the use of short-medium gas cells operated at high pressures. In contrast, long-medium schemes at low pressures are commonly perceived as inherently unsuitable for IAP generation due to the nonlinear phenomena that challenge favourable phase-matching conditions. Here we provide clear experimental evidence on the generation of isolated ext

Taking as its starting point the scholarly discussion about the possible death of the Aesopic fable towards the end of the eighteenth century, this article proposes a broadening of perspective, arguing for a thorough examination of the impact of modernity on some of the basic contexts and conditions of the genre. Four contextual factors are, subsequently, placed under scrutiny: the ethics of virtu

Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural cavity of asbestos-exposed individuals and rapidly leads to death. MPM harbors loss-of-function mutations in BAP1, NF2, CDKN2A, and TP53, but isolated deletion of these genes alone in mice does not cause MPM and mouse models of the disease are sparse. Here, we show that a proportion of human MPM harbor point muta

The modified Graeb Scale (mGS) is a semi-quantitative method to assess the extension of intraventricular hemorrhage (IVH) in patients with intracerebral hemorrhage (ICH). The mGS has been shown to prognosticate outcome after ICH in cohorts derived from convenience samples. We evaluated the external validity of mGS in supratentorial ICH-patients from an unselected cohort.

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of a high versus low added sugar consumption for primary prevention of CVD in the general population.

The large-scale applications of anion exchange membrane water electrolysis (AEMWEs) and zinc–air batteries (ZABs) are observably limited by the lack of highly active, multifunctional, and industrially applicable electrocatalysts. In this work, we report a solvent-free rapid pyrolysis strategy that successfully prepares a composite material of Pt8V–V2O3 heterostructure supported on nitrogen-doped p

BACKGROUND AND OBJECTIVE: A post hoc analysis of TITAN evaluated the clinical benefit of apalutamide plus androgen-deprivation therapy (ADT) versus ADT alone in metastatic hormone-sensitive prostate cancer (mHSPC) with high disease burden. METHODS: Patients were assessed in subgroups of those with four to fewer than ten, ten to <20, or ≥20 bone metastases; with lung but not liver metastases; and w

BACKGROUND: Recent research using a data-driven cluster approach has identified five discordant subclassifying body mass index (BMI) subgroups, characterized by cardiometabolic biomarkers deviated from those predicted by BMI.OBJECTIVE: This study aimed to investigate the associations of these subgroups with risks of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver-related

The purpose of this narrative review is to provide an evidence-based update on management strategies for young adults with meniscal tears, based on two recent randomized controlled trials comparing a surgical vs. non-surgical treatment strategy for this patient group. The results from these trials suggests that exercise therapy is a viable treatment alternative for young adults with a meniscal tea

This study explores structural modifications for reducing train-induced vibrations in timber buildings by modifying the building layout. A parameter study was conducted using a semi-analytical ground model coupled with a finite element structural model. The train load was modeled as a stationary oscillating point load of unit magnitude, applied on the ground surface. The analyzed frequency range,

High efficiency, low total harmonic distortion (THD), and near-unity power factor are essential for low voltage battery charging systems to satisfy modern power quality requirements. In this study, an isolated totem-pole power factor correction (PFC) integrated buck converter has been designed and analyzed for low-voltage battery charging applications. The proposed topology combines a bridgeless t

The European Union (EU) has recently presented several new legal proposals for promoting ecodesign and product labeling. The aim is to harmonize national practices and rules in the EU, to regulate issues like product lifetime and repairability in a more comprehensive way, to introduce new tools like digital product passports, and to introduce labeling schemes for repairability and durability. In p

Introduction: Vitamin D deficiency has previously been shown to be associated with cancer-related fatigue. If vitamin D deficiency affects fatigue in frail elderly has not been studied before. The aim of this study was to investigate associations between vitamin D, fatigue, frailty, and sarcopenia in frail elderly with cancer (FEC) and without cancer (FE) in comparison with healthy controls. Metho

Background. Adults with intellectual disability (ID) experience marked mental health inequities, yet population-wide estimates that capture both primary- and specialist-care diagnoses remain scarce. Methods. Using nationwide Swedish registries, including primary care, specialist, inpatient, prescription drug, criminal, and suspicion registers, we included all individuals born in Sweden between 195

Background/Objective: Genetic factors contribute significantly to Parkinson’s disease (PD), especially in cases with early onset or positive family history. However, previous investigations of the genetic landscape in PD populations were mainly based on targeted genotyping. The aim of this study was to investigate the prevalence of pathogenic variants in known PD-associated genes in a series of Sw

Purpose: Host factors, including genetic factors, are underutilized in breast cancer treatment selection. This study aimed to investigate AIB1 genotypes as pharmacogenetic markers for adjuvant breast cancer treatment. The prognostic impact of three functional polymorphisms associated with altered mRNA expression rs6094752 (low expression), rs2230782 (low expression) and rs2076546 (high expression)